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Immunosuppression with Cyclophosphamide Does Not Prevent Demyelination or Result in Uncontrolled Viral Replication in Coronavirus SD Infected Mice

  • J. S. Burks
  • L. Jankovsky
  • P. A. Licari
  • I. T. McNally
  • M. C. Kemp
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)

Abstract

Coronavirus SD following intracerebral inoculation has been shown to precipitate demyelination in the brains and spinal cords of weanling mice (1). Demyelination occurs at a time when virus cannot be isolated and some areas of demyelination are associated with a perivascular inflammatory response. Also, IgG is present in demyelinated areas. Since demyelination may be immunologically mediated, this study evaluates the effect of immunosuppression with cyclophosphamide (CY) on demyelination and viral replication.

Keywords

Untreated Mouse Demyelinating Lesion Intracerebral Inoculation Thymic Cortex Weanling Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Mendleman, P.M., L.D. Jankovsky, R.S. Murray, P. Licari, B.L. DeVald, J.C. Gerdes & J.S. Burks, 1983. Pathogenesis of Coronavirus SD in Mice. I Prominent Demyelination in the Absence of Infectious Virus Production. Arch. Neurol. In Press.Google Scholar
  2. 2.
    Gerdes, J.C, I. McNally, L. Hileman, J.S. Burks, 1982. Autoradiographic Detection of IgG and Viral Antigens. J. Immunol. Meth. 54:191–202.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. S. Burks
    • 1
    • 2
  • L. Jankovsky
    • 1
    • 2
  • P. A. Licari
    • 1
    • 2
  • I. T. McNally
    • 1
    • 2
  • M. C. Kemp
    • 1
    • 2
  1. 1.Center for Neurological DiseasesRocky Mountain Multiple Sclerosis CenterUSA
  2. 2.Veterans Administration Medical CenterUniversity of Colorado School of MedicineDenverUSA

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