Immunosuppression with Cyclophosphamide Does Not Prevent Demyelination or Result in Uncontrolled Viral Replication in Coronavirus SD Infected Mice
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Coronavirus SD following intracerebral inoculation has been shown to precipitate demyelination in the brains and spinal cords of weanling mice (1). Demyelination occurs at a time when virus cannot be isolated and some areas of demyelination are associated with a perivascular inflammatory response. Also, IgG is present in demyelinated areas. Since demyelination may be immunologically mediated, this study evaluates the effect of immunosuppression with cyclophosphamide (CY) on demyelination and viral replication.
KeywordsUntreated Mouse Demyelinating Lesion Intracerebral Inoculation Thymic Cortex Weanling Mouse
- 1.Mendleman, P.M., L.D. Jankovsky, R.S. Murray, P. Licari, B.L. DeVald, J.C. Gerdes & J.S. Burks, 1983. Pathogenesis of Coronavirus SD in Mice. I Prominent Demyelination in the Absence of Infectious Virus Production. Arch. Neurol. In Press.Google Scholar