Biology of Coronaviruses 1983

  • Volker ter Meulen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)


At the first international Symposion of coronaviruses held in Würzburg in 1980, studies on the biology of coronaviruses were mainly concerned with two subjects: coronavirus persistent infections in tissue cultures and the description of different disease models, in a variety of hosts, with the particular emphasise on subacute or chronic conditions. Much of the discussion centered around the possible mechanisms of persistence and the pathogenic factors playing a role in the development of the different disease types. However, due to the lack of basic information on the molecular biology of coronaviruses the majority of studies reported three years ago were of a more descriptive nature, and in the animal studies immunological and genetic aspects were mainly analysed. In the intervening period, although surprisingly little virological information has been obtained on coronavirus persistent infections in vitro and in vivo, the animal work has been concentrated on two virus groups, namely the murine and feline coronaviruses. Obviously, the involvement of multiple organs in different diseases associated with infections of the two virus groups has turned out to be the most interesting basis for the study of virus-cell and virus-host interactions and the analyses of viral and host factors involved in the development of different disease processes.


Basic Myelin Protein Persistent Infection Experimental Allergic Encephalomyelitis Virus Group Mouse Hepatitis Virus 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Volker ter Meulen
    • 1
  1. 1.Institute of Virology and ImmunobiologyUniversity of WürzburgWürzburgGermany

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