Biochemistry of Coronaviruses 1983

  • Brian W. J. Mahy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)


The first international symposium on coronaviruses was held in 1980. At that time the unique structural features of this virus family were recognised, and much of the discussion centred around evidence for an unusual replication strategy involving a ‘nested set’ of six subgenomic mRNA’s (see Mahy, 1981). Most of the molecular biological studies then reported concerned avian or murine coronaviruses, and these still continue to dominate the field, with little new information available on the bovine, feline or porcine coronaviruses, for example. Major advances in 1983 have resulted from application of the new techniques of nucleic acid cloning and sequencing to the avian and murine genomes, and although only two of the genes (N and E1) have been analysed so far, the interpretation of experiments to study replication is already on a much firmer basis.


Infectious Bronchitis Virus Mouse Hepatitis Virus Murine Hepatitis Virus Murine Coronavirus Corona Virus 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Brian W. J. Mahy
    • 1
  1. 1.Division of Virology, Department of PathologyUniversity of CambridgeEngland

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