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Viral Hepatitis in Mice and ADP-Ribose Metabolism

  • Hans Kröger
  • Monika Klewer
  • K. Noel Masihi
  • Werner Lange
  • Beate Rohde-Schultz
Chapter
  • 34 Downloads

Abstract

We have shown earlier that the toxicity of endotoxin can be prevented to a large extent by antagonists of ADP-ribose metabolism (1). On the other hand there are some indications that muramyldipeptide (MDP) interferes with the this metabolism also (2). It was reported in 1980 that MDP, in combination with trehalose dimycolate, could induce resistance against influenza virus infection (3). In this chapter we are dealing with the influence of muramyldipeptide and benzamide upon the mouse hepatitis virus type 3 (MHV3).

Keywords

Histopathological Examination Infected Animal Necrotic Lesion Percent Survival Microbial Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

GOT

Glutamic-oxalacetic transaminase

GPT

Glutamic-pyruvic transaminase

MDP

Muramyldipeptide

MHV3

Mouse hepatitis virus type 3

References

  1. 1.
    Kröger, H., Grätz, R. (1983) Falk Symposium No. 38 Mechanisms of Hepatocyte Injury and Death, BaselGoogle Scholar
  2. 2.
    Kroger, H., Masihi, K.N., Lange, W. (1987) Int Symp Immunomodulators and Nonspecific Host Mechanisms Against Microbial Infections, BerlinGoogle Scholar
  3. 3.
    Masihi, K.N., Brehmer, W., Lange, W., Ribi, E. (1980) 4th International Congress of Immunology, J.L. Prend’Homme and V.A.L. Hawken (eds.), Paris, Abstr.Google Scholar
  4. 4.
    Bergmeyer, H.U. (ed.) (1974) Methoden der Enzymatischen Analyse. Verlag Chemie, WeinheimGoogle Scholar
  5. 5.
    Kröger, H., Grätz, R., Musetean, C., Haase, J. (1981) Arzneimittel-Forsch 31: 989Google Scholar
  6. 6.
    Kröger, H., Grätz, R., Grahn, H. (1983) Int J Biochem 15: 1131–1136PubMedCrossRefGoogle Scholar
  7. 7.
    Galanos, C., Freudenberg, M.A., Reutter, W. (1979) Proc Natl Acad Sci (USA) 76: 5939–5942CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Hans Kröger
    • 1
  • Monika Klewer
    • 1
  • K. Noel Masihi
    • 1
  • Werner Lange
    • 1
  • Beate Rohde-Schultz
    • 1
  1. 1.Robert Koch-InstitutBerlin 65West Germany

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