Viral Hepatitis in Mice and ADP-Ribose Metabolism

  • Hans Kröger
  • Monika Klewer
  • K. Noel Masihi
  • Werner Lange
  • Beate Rohde-Schultz


We have shown earlier that the toxicity of endotoxin can be prevented to a large extent by antagonists of ADP-ribose metabolism (1). On the other hand there are some indications that muramyldipeptide (MDP) interferes with the this metabolism also (2). It was reported in 1980 that MDP, in combination with trehalose dimycolate, could induce resistance against influenza virus infection (3). In this chapter we are dealing with the influence of muramyldipeptide and benzamide upon the mouse hepatitis virus type 3 (MHV3).


Histopathological Examination Infected Animal Necrotic Lesion Percent Survival Microbial Infection 
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Glutamic-oxalacetic transaminase


Glutamic-pyruvic transaminase




Mouse hepatitis virus type 3


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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Hans Kröger
    • 1
  • Monika Klewer
    • 1
  • K. Noel Masihi
    • 1
  • Werner Lange
    • 1
  • Beate Rohde-Schultz
    • 1
  1. 1.Robert Koch-InstitutBerlin 65West Germany

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