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Monoclonal Antibodies as Tools for Human Genetic Analysis

  • Chapter
Monoclonal Antibodies

Abstract

Research in human genetics includes areas such as mRNA and gene isolation; structural studies of enzymes and proteins and the interaction of their subunits; structural and population studies of protein polymorphisms; somatic cell genetics, including gene mapping; development and differentiation involving cell-and tissue-specific cell-surface antigens; chromosome structure and function; immunogenetics; and clinical genetics, including inherited metabolic disorders, chromosome abnormalities, and transplantation antigens. It is safe to predict that monoclonal antibodies will be used in all of these areas within a short time. Their advantages over conventional antisera for human genetic analysis, as for other areas, lie in their monospecificity, high titer, and availability in large quantities. Coupled with this is the fact that these extremely pure and specific antibodies may be produced from immunizations with relatively crude material. Of additional advantage to human genetics is their potential in clinical work for diagnostic and possibly therapeutic purposes.

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Author information

Author notes

  1. E. Solomon

    Present address: Imperial Cancer Research Fund, P. O. Box 123, Lincoln’s Inn Fields, London, WC2A 3PX, England

  2. E. A. Jones

    Present address: Division of Immunology, Stanford University Medical School, Stanford, California, 94305, USA

Authors and Affiliations

  1. Genetics Laboratory, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, England

    E. Solomon & E. A. Jones

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  1. E. Solomon
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Editors and Affiliations

  1. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    Roger H. Kennett  & Thomas J. McKearn  & 

  2. The Wistar Institute, Philadelphia, Pennsylvania, USA

    Kathleen B. Bechtol

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© 1980 Plenum Press, New York

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Solomon, E., Jones, E.A. (1980). Monoclonal Antibodies as Tools for Human Genetic Analysis. In: Kennett, R.H., McKearn, T.J., Bechtol, K.B. (eds) Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7505-4_6

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  • DOI: https://doi.org/10.1007/978-1-4615-7505-4_6

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