Ischemic/Hypoxic and Reperfusion/Reoxygenation Contractures: Mechanisms

  • A. H. Henderson


By the late 1960s it had become apparent that myocardial ischemia was associated with a reversible rise in end-diastolic pressure [1]. Whether this represented a change in myocardial stiffness was not then clear and was to remain controversial for some years: the complexities of dissociating hemodynamic from myocardial properties are not unique to systolic function. The observation nevertheless marked a renewal of interest in diastolic function whose importance had been rather neglected since before the days of Harvey.


Myocardial Stiffness Diastolic Stiffness Sarcoplasmic Reticulum Function Papillary Muscle Preparation Experimental Coronary Artery 
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© Martinus Nijhoff Publishing 1987

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  • A. H. Henderson

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