Is Ischemic Contracture Preceded by a Rise in Free Calcium?

  • William H. Barry


Initially during myocardial hypoxia or ischemia, development of contractile force declines. Ultimately the myocardial cell fails completely to develop contractile force and is usually fully relaxed at this stage [1]. With continued impairment of adenosine triphosphate (ATP) synthesis, the ischemic myocardial cell begins to develop an increase in resting tension. This increase in resting tension could be due to a rise in cytosolic free Ca2+ ion concentration, [Ca2+]i, or a fall in ATP concentration, which could produce rigor due to failure of actin-myosin cross-bridge dissociation [2].


High Energy Phosphate Energy Deprivation Ischemic Contracture Contracture Development Culture Heart Cell 
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© Martinus Nijhoff Publishing 1987

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  • William H. Barry

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