Advertisement

Diastolic Ventricular Function in Primary and Secondary Hypertrophy: The Influence of Verapamil

  • W. H. Bleifeld

Abstract

Left ventricular diastolic function is of clinical importance [1], because disturbed relaxation results in impaired left ventricular filling and an increase of left ventricular filling pressure with breathlessness during exercise or at rest. Although hypertrophy in highly trained athletes does not appear to be accompanied by abnormalities of systolic or diastolic function as evaluated from the end-diastolic pulmonary artery pressure [2], patients with left ventricular hypertrophy due to pressure overload or primary myocardial disease usually manifest increased filling pressure and, depending on the degree of their disease, may exhibit clinical signs of left heart failure.

Keywords

Diastolic Function Left Ventricular Filling Stroke Volume Index Filling Period Left Ventricular Outflow Tract Obstruction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Grossman W, McLaurin LP (1976). Diastolic properties of the left ventricle. Ann Intern Med 84: 316–326.PubMedGoogle Scholar
  2. 2.
    Markworth P, Bleifeld W (1982). Regulation des Herzminutenvolumens ausdauertrainierter Spitzensportler. Z Kardiol. Suppl 178 (abstr).Google Scholar
  3. 2a.
    Fleckenstein A, Nakayama K, Fleckenstein-Grün G,. Byon YK (1975) Interactions of vaso-active ions and drugs with Ca-dependent excitation-contraction coupling of vascular smooth muscle. In Carafoli et al (eds): Calcium Transport in Contraction and Secretion. Amsterdam: North-Holland, p 555.Google Scholar
  4. 3.
    Nayler WG, Williams A (1978). Relaxation in heart muscle: Some morphological and biochemical considerations. Eur J Cardiol (suppl) 7: 35–50.Google Scholar
  5. 4.
    Kaltenbach M, Hopf R, Keller M (1976). Calciumantagonistische Therapie bei hypertrophobstruktiver Kardiomyopathie. Dtsch Med Wochenschr 101: 1284–1287.PubMedCrossRefGoogle Scholar
  6. 5.
    Kuhn H, Thelen U, Leuner C, et al (1980). Long-term treatment of hypertrophic non-obstructive cardiomyopathy ( HNCM) with verapamil. Z Kardiol 69: 669–675.Google Scholar
  7. 6.
    Hanrath P, Mathey DG, Siegert R, Bleifeld W (1980). Left ventricular relaxation and filling pattern in different forms of left ventricular hypertrophy: An echocardiographic study. Am J Cardiol 45: 15–23.Google Scholar
  8. 7.
    Hanrath P, Mathey DG, Kremer P, et al (1980). Effect of verapamil on left ventricular isovolumic relaxation time and regional left ventricular filling in hypertrophic cardiomyopathy. Am J Cardiol 45: 12–58.Google Scholar
  9. 8.
    Hanrath P, Schlüter M, Sonntag F, et al (1983). Influence of verapamil therapy on left ventricular performance at rest and during exercise in hypertrophic cardiomyopathy. Am J Cardiol 52: 544.PubMedCrossRefGoogle Scholar
  10. 9.
    Krebs W, Hanrath P, Bleifeld W, Effert S (1977). Rechnergestutzte Auswertung von MMode-Echokardiogrammen. Herz-Kreislauf 9: 519–525.Google Scholar
  11. 10.
    Sanderson JE, Gibson DG, Brown DJ, Goodwin JF (1977). Left ventricular filling in hypertrophic cardiomyopathy: An angiographic study. Br Heart J 39: 661–670.Google Scholar
  12. 11.
    Cohn PF, Liedtke AJ, Serur J, et al (1972). Maximal rate of pressure fall (peak negative dP/dt) during ventricular relaxation. Cardiovasc Res 6: 263–267.PubMedCrossRefGoogle Scholar
  13. 12.
    Weisfeldt ML, Scully HE, Frederiksen J, et al (1974). Hemodynamic determinants of maximum negative dP/dt and periods of diastole. Am J Physiol 227: 613–621.PubMedGoogle Scholar
  14. 13.
    Benchimol A, Ellis JG (1967). A study of the period of isovolumic relaxation in normal subjects and in patients with heart disease. Am J Cardiol 19: 196–206.PubMedCrossRefGoogle Scholar
  15. 14.
    Papapietro HC, Coughlan D, Zissermann RO, et al (1979). Impaired maximal rate of left ventricular relaxation in patients with coronary artery disease and left ventricular dysfunction. Circulation 59: 984–990.PubMedGoogle Scholar
  16. 15.
    Mathey D, Bleifeld W, Franken G (1974). Left ventricular relaxation and diastolic stiffness in experimental myocardial infarction. Cardiovasc Res 8: 583–692.CrossRefGoogle Scholar
  17. 16.
    Hanrath P, Mathey D, Montz R, et al (1981). Myocardial thallium-201 imaging in hypertrophic obstructive cardiomyopathy. Eur Heart J 2: 177–185.PubMedGoogle Scholar
  18. 17.
    Spirito P, Maron BJ, Chiarella F, et al (1985). Diastolic abnormalities in patients with hypertrophic cardiomyopathy: relation to magnitude of left ventricular hypertrophy. Circulation 72: 310.PubMedCrossRefGoogle Scholar
  19. 18.
    Panidis IP, Nestico P, Hakki AH, et al (1986). Systolic and diastolic left ventricular performance at rest and during exercise in apical hypertrophic cardiomyopathy. Am J Cardiol 57: 356.PubMedCrossRefGoogle Scholar
  20. 19.
    Singh BN, Roche AHG (1977). Effects of intravenous verapamil on hemodynamics in patients with heart disease. Am Heart J 94: 593–599.PubMedCrossRefGoogle Scholar
  21. 20.
    Ferlinz J, Easthope JL, Aronow WS (1979). Effects of verapamil on myocardial performance in coronary disease. Circulation 59: 313–319.PubMedGoogle Scholar
  22. 21.
    Chatterjee K, Raff G, Anderson D, Parmley WW (1982). Hypertrophic cardiomyopathytherapy with slow channel inhibiting agents. Prog Cardiovasc Dis 25: 193–210.PubMedCrossRefGoogle Scholar
  23. 22.
    Bonow RO, Dilsizian V, Rosing DR, et al (1985). Verapamil-induced improvement in left ventricular diastolic filling and increased exercise tolerance in patients with hypertrophic cardiomyopathy: Short-and long-term effects. Circulation 72: 853.Google Scholar
  24. 23.
    Spicer RL, Rocchini AP, Crowley DC, Rosenthal A (1984). Chronic verapamil therapy in pediatric and young adult patients with hypertrophic cardiomyopathy. Am J Cardiol 53: 1614.PubMedCrossRefGoogle Scholar
  25. 24.
    Lorell BH, Paulus WJ, Grossman W, et al (1982). Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy. Circulation 65: 499.PubMedCrossRefGoogle Scholar
  26. 25.
    Betocchi S, Bonow RO, Bacharach SL, et al (1982). Isovolumic relaxation period in hypertrophic cardiomyopathy: assessment by radionuclide angiography. J Am Coll Cardiol 7: 74.CrossRefGoogle Scholar
  27. 26.
    Cserhalmi L, Assmann I, Glavanov M, et al (1984). Langzeittherapie der hypertrophischen obstruktiven und nichtobstruktiven Kardiomyopathie mit nifedipin im Vergleich zu Propranolol. ( Long-term therapy of hypertrophic obstructive and non-obstructive cardiomyopathy with nifedipine in comparison to propranolol ). Z Gesamte Inn Med 39: 330.Google Scholar
  28. 27.
    Kurnik PB, Courtois MR, Ludbrook PA (1986). Effect of nifedipine on intrinsic myocardial stiffness in man. Circulation 74: 126.PubMedCrossRefGoogle Scholar
  29. 28.
    Suwa M, Hirota Y, Kawamara K (1984). Improvement in left ventricular diastolic function during intravenous and oral diltiazem therapy in patients with hypertrophic cardiomyopathy: An echocardiographic study. Am J Cardiol 54: 1047.Google Scholar

Copyright information

© Martinus Nijhoff Publishing 1987

Authors and Affiliations

  • W. H. Bleifeld

There are no affiliations available

Personalised recommendations