Advertisement

Effects of Hypoxia on Relaxation of the Hypertrophied Ventricle

  • Beverly H. Lorell
  • Laura F. Wexler
  • Shin-ichi Momomura
  • Ellen Weinberg
  • Joanne Ingwall
  • Carl S. Apstein

Abstract

Cardiac hypertrophy is a compensatory response to chronic pressure-overload of the heart. However, studies in both animal models and in patients provide evidence that adaptive pressure-overload cardiac hypertrophy may be associated with an increased susceptibility to the development of diastolic dysfunction during ischemia or hypoxia. In this regard, Bache and coworkers have shown that left ventricular end-diastolic pressure rises in response to ischemia induced by pacing tachycardia in dogs with chronic left ventricular hypertrophy [1]. Similarly, Fifer and coworkers have recently shown that patients with normal coronary arteries and pressure-overload hypertrophy due to aortic stenosis demonstrate a striking rise in left ventricular diastolic pressure and an impairment of left ventricular relaxation during transient angina induced by pacing tachycardia [2]. It is likely that these transient changes in diastolic function in hearts with pressure-overload hypertrophy are related in part to the development of global left ventricular subendocardial ischemia. Coronary vascular reserve appears to be impaired in dogs with chronic aortic stenosis and in patients with pressure-overload hypertrophy [3–5]. Furthermore, relative hypoperfusion of the subendocardium has been shown in dogs with aortic stenosis in whom metabolic evidence of ischemia was induced by pacing tachycardia [1].

Keywords

Cardiac Hypertrophy Coronary Flow Hypertrophied Heart Left Ventricular Relaxation Left Ventricular Systolic Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bache RJ, Arentzen CE, Simon AB, Vrobel TR (1984). Abnormalities in myocardial perfusion during tachycardia in dogs with left ventricular hypertrophy: Metabolic evidence for myocardial ischemia. Circulation 69: 409.Google Scholar
  2. 2.
    Fifer MA, Bourdillon PD, Lorell BH (1986). Altered left ventricular diastolic properties during pacing-induced angina in patients with aortic stenosis. Circulation 74: 675.PubMedCrossRefGoogle Scholar
  3. 3.
    Marcus ML, Doty DB, Hiratzka LF, et al (1982). Decreased coronary reserve: A mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries. N Engl J Med 307: 1362.Google Scholar
  4. 4.
    Pichard AD, Gorlin R, Smith H, et al (1981). Coronary flow studies in patients with left ventricular hypertrophy of the hypertensive type. Am J Cardiol 47: 547.PubMedCrossRefGoogle Scholar
  5. 5.
    Bache RJ, Arentzen CE, Simon AB, Vrobel TR (1984). Abnormalities in myocardial perfusion in dogs with left ventricular hypertrophy: Metabolic evidence for myocardial ischemia. Circulation 69: 409.Google Scholar
  6. 6.
    Bourdillon PD, Lorell BH, Mirsky I, et al (1983). Increased regional myocardial stiffness of the left ventricle during pacing-induced angina in man. Circulation 67: 316.PubMedCrossRefGoogle Scholar
  7. 7.
    Serizawa T, Carabello BA, Grossman W (1980). Effect of pacing-induced ischemia on left ventricular diastolic pressure-volume relations in dogs with coronary stenoses. Circ Res 46: 430.PubMedGoogle Scholar
  8. 8.
    Isoyama S, Lorell BH, Grice WN, et al (1985). Increased diastolic chamber stiffness during simulated angina in isolated hearts. Circulation 72: III - 72 (abstract).Google Scholar
  9. 9.
    Gwathmey JK, Morgan JP (1985). Altered calcium handling in experimental pressure-overload hypertrophy in the ferret. Circ Res 57: 836.PubMedGoogle Scholar
  10. 10.
    Lorell BH, Wexler LF, Momomura S, et al (1986). The influence of pressure overload left ventricular hypertrophy on diastolic properties during hypoxia in isovolumically contracting rat hearts. Circ Res 58: 653.PubMedGoogle Scholar
  11. 11.
    Apstein CS, Mueller M, Hood WB Jr (1977). Ventricular contracture and compliance changes with global ischemia and reperfusion, and their effect on coronary resistance in the rat. Circ Res 41:206.Google Scholar
  12. 12.
    Raff GL, Glantz SA (1981). Volume loading slows left ventricular isovolumic relaxation rate. Circ Res 48: 813.PubMedGoogle Scholar
  13. 13.
    Apstein CS, Puchner E, Brachfeld N (1970). Improved automated lactate method. Anal Biochem 38: 20.PubMedCrossRefGoogle Scholar
  14. 14.
    Wexler LF, Lorell BH, Momomura S, et al (1985). Cardiac hypertrophy: Hemodynamic and metabolic 31P-NMR response to hypoxia. Circulation 72: III - 337 (abstract).Google Scholar
  15. 15.
    Vogel WM, Apstein CS, Briggs LL, et al (1982). Acute alterations in left ventricular diastolic chamber stiffness. Circ Res 51: 465.PubMedGoogle Scholar
  16. 16.
    LeCarpentier YC, Chuck LHS, Housman PR, et al (1979). Nature of load dependence of relaxation in cardiac muscle. Am J Physiol 237: H455.PubMedGoogle Scholar
  17. 17.
    LeCarpentier Y, Martin JL, Gastineau, P, Hatt PY (1982). Load dependence of mammalian heart relaxation during cardiac hypertrophy and heart failure. Am J Physiol 242: H855.PubMedGoogle Scholar
  18. 18.
    Brutsaert DL, Rademakers FE, Sys SU (1984). Triple control of relaxation: Implications in cardiac disease. Circulation 69: 521.Google Scholar
  19. 19.
    Chuck LH, Goethals MA, Parmley WW, Brutsaert DL (1981). Load insensitive relaxation caused by hypoxia in mammalian cardiac muscle. Circ Res 48: 797.PubMedGoogle Scholar
  20. 20.
    Nayler WG, Poole-Wilson PA, Williams A (1979). Hypoxia and calcium. J Mol Cell Cardiol 11: 683.PubMedCrossRefGoogle Scholar
  21. 21.
    Sordahl LA, McCollum WB, Wood WG, Schwartz A (1973). Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure. Am J Physiol 224: 497.PubMedGoogle Scholar
  22. 22.
    Allen DG, Orchard CH (1983). Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle. J Physiol 339: 107.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing 1987

Authors and Affiliations

  • Beverly H. Lorell
  • Laura F. Wexler
  • Shin-ichi Momomura
  • Ellen Weinberg
  • Joanne Ingwall
  • Carl S. Apstein

There are no affiliations available

Personalised recommendations