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Diastolic Myocardial Mechanics and the Regulation of Cardiac Performance

  • J. Scott Rankin
  • J. William Gaynor
  • Michael P. Feneley
  • Donald D. Glower
  • John A. Spratt
  • George S. Tyson
  • George W. Maier
  • Craig O. Olsen
  • Thomas N. Skelton
  • Thomas M. Bashore

Abstract

Over the past 15 years, the primary goal of our physiology laboratory has been to improve the understanding of basic myocardial function in both normal and diseased hearts. Very early in our studies, it became evident that existing descriptors of myocardial performance were deficient, and initial efforts were expended to develop basic models of ventricular geometry, diastolic properties, and systolic function. Later work has been directed toward applying these models to the study of pathophysiology in ischemic heart disease and chronic volume overload. Although this investigation is still in progress, enough information is currently available to provide insight into basic aspects of diastolic myocardial function, to propose several hypotheses on how the heart adapts to clinical heart disease, and to provide direction for future clinical investigation of myocardial mechanics in humans. This chapter will review these topics primarily through publications from our laboratory, each of which contains full references.

Keywords

Ventricular Pressure Stroke Work Diastolic Property Ventricular Geometry Intact Heart 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rankin JS, Arentzen CE, Ring WS, et al (1980). The diastolic mechanical properties of the intact left ventricle. Fed Proc 39: 141–147.PubMedGoogle Scholar
  2. 2.
    Rankin JS, McHale PA, Arentzen CE, et al (1976). The three-dimensional dynamic geometry of the left ventricle in the conscious dog. Circ Res 39: 304–313.PubMedGoogle Scholar
  3. 3.
    Rankin JS, Arentzen CE, McHale PA, et al (1977). Viscoelastic properties of the diastolic left ventricle in the conscious dog. Circ Res 41: 37–45.PubMedGoogle Scholar
  4. 4.
    Yellin EL, Masatsugu H, Yoran C, et al (1986). Left ventricular relaxation in the filling and nonfilling intact canine heart. Am J Physiol 250: H620 - H629.PubMedGoogle Scholar
  5. 5.
    Momomura S, Bradley AB, Grossman W (1984). Left ventricular diastolic pressure-segment length relations and end-diastolic distensibility in dogs with coronary stenoses: An angina-physiology model. Circ Res 55: 203–214.Google Scholar
  6. 6.
    Olsen CO, Tyson GS, Maier GW, et al (1985). Diminished stroke volume during inspiration: A reverse thoracic pump. Circulation 72: 668–679.Google Scholar
  7. 7.
    Tyson GS Jr, Olsen CO, Maier GW, et al (1982). Dimensional characteristics of left ventricular function after coronary artery bypass grafting. Circulation 66 (suppl I): 16–25.Google Scholar
  8. 8.
    Rankin JS, Olsen CO, Arentzen CE, et al (1982). The effects of airway pressure on cardiac function in intact dogs and man. Circulation 66: 108–120.PubMedCrossRefGoogle Scholar
  9. 9.
    Tyson GS Jr, Maier GW, Olsen CO, et al (1984). Pericardial influences on ventricular filling in the conscious dog: An analysis based on pericardial pressure. Circ Res 54: 173–184.Google Scholar
  10. 10.
    Snow ND, Burkhoff D, Glower DD, et al (1985). Evaluation of the vena caval occlusion technique for assessing systolic myocardial performance. Circulation 72 (suppl III): III - 341.Google Scholar
  11. 11.
    Bashore TM, Walker S, Van Fossen D, et al (1985). Use of inferior vena caval occlusion to acutely alter preload in man. Circulation 72 (suppl III): III - 43.Google Scholar
  12. 12.
    Glantz SA (1975). A constitutive equation for the passive properties in the left ventricle. J Appl Physiol 39: 665–671.Google Scholar
  13. 13.
    Olsen CO, Lee KL, Tyson GS, et al. Diastolic anisotropic properties of the left ventricle in the conscious dog. Submitted for publication.Google Scholar
  14. 14.
    Olsen CO, Tyson GS, Maier GW, et al (1983). Dynamic ventricular interaction in the conscious dog. Circ Res 52: 85–104.PubMedGoogle Scholar
  15. 15.
    Rankin JS, Olsen CO (1980). The diastolic filling of the left ventricle. Eur Heart J 1: 95–105.Google Scholar
  16. 16.
    Olsen CO, Van Trigt P II, Rankin JS (1981). The dynamic geometry of the intact left ventricle. Fed Proc 40: 2023–2030.PubMedGoogle Scholar
  17. 17.
    Glower DD, Spratt JA, Snow ND, et al (1985). Linearity of the Frank-Starling relationship in the intact heart: The concept of preload recruitable stroke work. Circulation 71: 994–1009.Google Scholar
  18. 18.
    Spratt JA, Glower DD, Snow ND, et al (1984). Three-dimensional analysis of stroke work in conscious dog. Circulation 70 (II): 936.Google Scholar
  19. 19.
    Van Trigt P III, Olsen CO, Pellom GL, et al (1980). Do acute hemodynamic interventions alter diastolic mechanics of the left ventricle? Circulation 62(III): 778, 1980.Google Scholar
  20. 20.
    Edwards CH II, Rankin JS, Ling D, et al (1981). The effect of ischemia on left ventricular regional function in the conscious dog. Am J Physiol 240: H413 - H420.PubMedGoogle Scholar
  21. 21.
    Glower DD, Wolfe JA, Spratt JA, et al () Relationship between reversal of diastolic creep and recovery of systolic function after ischemic myocardial injury in the conscious dog. Circ Res: in press.Google Scholar
  22. 22.
    Glower DD, Spratt JA, Kabas JS, et al. Quantification of regional myocardial function after acute ischemic injury: Application of preload recruitable stroke work. Am J Physiol: in press.Google Scholar
  23. 23.
    Kabas JS, Glower DD, Spratt JA, et al (1985). Effects of afterload and inotropic state on diastolic properties after ischemic injury. Circulation 72 (III): III - 283.Google Scholar
  24. 24.
    Kabas JS, Glower DD, Spratt JS, et al (1985). Effects of dopamine on functional recovery after reversible ischemic myocardial injury. Surg Forum: 36: 185.Google Scholar
  25. 25.
    Rankin JS, Ring WS, Arentzen CE, et al (1977). The functional reserves of the left ventricle in chronic volume overload. Circulation 56 (II): 906.Google Scholar
  26. 26.
    Ross J Jr (1974). Adaptation of the left ventricle to chronic volume overload. Circ Res 34 and 35 (II): 64–70.Google Scholar
  27. 27.
    Linzbach AJ (1960). Heart failure from the point of view of quantitative anatomy. Am J Cardiol 5: 370–382.PubMedCrossRefGoogle Scholar
  28. 28.
    Hood WP Jr, Rackley CE, Rolett EL (1963). Well stress in the normal and hypertrophied human left ventricle. Am J Physiol 22: 550–558.Google Scholar
  29. 29.
    Grossman W, Jones D, McLaurin LP (1975). Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 56: 56–64.PubMedCrossRefGoogle Scholar
  30. 30.
    Gaasch WH, Andrias CW, Levine JH (1978). Chronic aortic regurgitation: The effect of aortic valve replacement on left ventricular volume, mass and function. Circulation 58: 825–836.Google Scholar
  31. 31.
    Rankin JS (1980). The chamber dynamics of the intact left ventricle. In Baan J, Arntzenius AC, Yellin ED, (eds): Cardiac Dynamics. London: Martinus Nijhoff Publishers, pp 95–106.CrossRefGoogle Scholar
  32. 32.
    Rankin JS (1986). Mitral and tricuspid valve disease. In Sabiston DC Jr (ed): A Textbook of Surgery, 13th ed. Philadelphia: Saunders, 2344–2373.Google Scholar
  33. 33.
    Gaynor JW: Unpublished data.Google Scholar
  34. 34.
    Rankin JS, Newman GE, Muhlbaier LH, et al (1985). The effects of coronary revascularization of left ventricular function in ischemic heart disease. J Thorac Cardiovasc Surg 90: 818–832. 1985.Google Scholar
  35. 35.
    Spratt JA, Tyson GS, Glower DD, et al. The end-systolic pressure-volume relationship in conscious dogs. Circulation: In press.Google Scholar

Copyright information

© Martinus Nijhoff Publishing 1987

Authors and Affiliations

  • J. Scott Rankin
  • J. William Gaynor
  • Michael P. Feneley
  • Donald D. Glower
  • John A. Spratt
  • George S. Tyson
  • George W. Maier
  • Craig O. Olsen
  • Thomas N. Skelton
  • Thomas M. Bashore

There are no affiliations available

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