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The Effects of Cardiac Hypertrophy on Intracellular Ca2+ Handling

  • James P. Morgan
  • Roderick MacKinnon
  • Marc Feldman
  • William Grossman
  • Judith Gwathmey

Abstract

The development of cardiac hypertrophy is associated with marked changes in contractile function in many mammalian species [1]. In isolated ventricular muscle, these changes usually manifest themselves as alterations in force generation and in the rate of relaxation [2]. The studies described in this chapter were designed to answer the question of whether the mechanical abnormalities of hypertrophied muscle are related to changes in intracellular Ca2+ handling. Four models of hypertrophy will be considered, including (1) pressure-overload right ventricular hypertrophy in ferrets, (2) alteration of the thyroid state in ferrets, (3) the compensatory hypertrophy that occurs in patients with heart failure, and (4) hypertrophic cardiomyopathy in humans.

Keywords

Sarcoplasmic Reticulum Cardiac Hypertrophy Papillary Muscle Calcium Transient Thyroid State 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing 1987

Authors and Affiliations

  • James P. Morgan
  • Roderick MacKinnon
  • Marc Feldman
  • William Grossman
  • Judith Gwathmey

There are no affiliations available

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