Neoantigen Expression in Chemical Carcinogenesis

  • Robert W. Baldwin
  • Michael R. Price
Part of the Cancer, A Comprehensive Treatise book series (C)


Neoplastic transformation induced by chemical carcinogens results in the expression in transformed cells of antigens that are not present in their normal cell counterpart, at least in the adult host. In early studies with chemically induced tumors (Foley, 1953; Baldwin, 1955; Prehn and Main, 1957), neoantigens were defined by their capacity to elicit immunity to transplanted tumor and were termed “tumor-specific transplantation antigens.” It is now evident that immune responses are elicited against these antigens in the autochthonous host, and considerable effort has been directed to resolve their role as a limiting (or enhancing) component of chemical carcinogenesis. It is appropriate to refer to these classical neoantigens, which are characterized by an immunological specificity that is unique to individual tumors, as “tumor-associated rejection antigens” (the term “tumor-specific” has been avoided here since recent experiments have raised the possibility that these antigens may be induced in nontransformed cells and so cannot be viewed as specific markers of malignancy).


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  1. Abelev, G. I., Perova, S. D., Khramkova, N. I., Postnikova, A. A., and Irlin, I. S., 1963, Production of embryonal a-globulin by transplantable mouse hepatomas, Transplantation 1: 174.PubMedGoogle Scholar
  2. Abelev, G. I., Engelhardt, N. V., and Elgort, D. A., 1979, Immunochemical and immunohistochemical micromethods in the study of tumor-associated embryonic antigens, Methods Cancer Res. 18: 1.Google Scholar
  3. Abeyounis, C. J., and Milgrom, F., 1976, A thermostable antigen characteristic for carcinogen-induced rat intestinal tumors, j Immunol. 116: 30.PubMedGoogle Scholar
  4. Alaba, O., Rogers, M. J., and Law, L. W., 1979, Rauscher leukemia virus-induced tumor antigens: Complete separation from gp70, p30 and H-2, Int. j. Cancer 24: 608.PubMedGoogle Scholar
  5. Al-Sheikly, A. W., Embleton, M. J., and Price, M. R., 1980, Detection of tumor specific antigens and alloantigens using a radioisotopic antiglobulin assay, in: Biology of the Cancer Cell ( K. Letnansky, ed.), pp. 121–126, Kugler, Amsterdam.Google Scholar
  6. Ambrose, K. R., Anderson, N. G., and Coggin, J. H., 1971, Interruption of SV40 oncogenesis with human foetal antigen, Nature (London) 233: 194.Google Scholar
  7. Apffel, C. A., Arnason, B. G., and Peters, J. H., 1966, Induction of tumor immunity with tumor cells treated with iodoacetate, Nature (London) 209: 694.Google Scholar
  8. Appella, E., Dubois, G. C., Natori, T., Rogers, M. J., and Law, L. W., 1978, Histocompatibility antigens and tumor-specific transplantation antigens of methylcholanthrene-induced sarcomas, in: Biological Markers of Neoplasia: Basic and Applied Aspects ( R. W. Ruddon, ed.), pp. 213–225, Elsevier, New York.Google Scholar
  9. Baldwin, R. W., 1955, Immunity to methylcholanthrene-induced tumours in inbred rats following atrophy and regression of implanted tumors, Br. J. Cancer 9: 652.PubMedCentralPubMedGoogle Scholar
  10. Baldwin, R. W., 1973, Immunological aspects of chemical carcinogenesis, Adv. Cancer Res. 18: 1.PubMedGoogle Scholar
  11. Baldwin, R. W., 1976, Role of immunosurveillance against chemically induced rat tumors, Transplant. Rev. 28: 62.PubMedGoogle Scholar
  12. Baldwin, R. W., 1977, Natural cell mediated immunity: Immune surveillance revisited, Nature (London) 270: 557.Google Scholar
  13. Baldwin, R. W., and Barker, C. R., 1967a, Tumor-specific antigenicity of aminoazo-dye-induced rat hepatomas, Int. J Cancer 2: 355.PubMedGoogle Scholar
  14. Baldwin, R. W., and Barker, C. R., 1967b, Demonstration of tumour-specific humoral antibody against aminoazo-dye-induced rat hepatomata, Br. J. Cancer 21: 793.PubMedCentralPubMedGoogle Scholar
  15. Baldwin, R. W., and Byers, V. S., 1979, Immunoregulation by bacterial organisms and their role in the immunotherapy of cancer, Springer Semin. Immunopathol. 2: 79.Google Scholar
  16. Baldwin, R. W., and Embleton, M. J., 1969, Immunology of 2-acetylaminofluorene-induced rat mammary adenocarcinomas, Int. J Cancer 4: 47.PubMedGoogle Scholar
  17. Baldwin, R. W., and Embleton, M. J., 1971, Tumor-specific antigens in 2-acetylaminofluoreneinduced rat hepatomas and related tumors, Isr. J. Med. Sci. 7: 144.PubMedGoogle Scholar
  18. Baldwin, R. W., and Embleton, M. J., 1974, Neoantigens on spontaneous and carcinogen-induced rat tumours defined by in vitro lymphocytotoxicity, Int. J. Cancer 13: 433.PubMedGoogle Scholar
  19. Baldwin, R. W., and Moore, M., 1971, Tumour-specific antigens and tumour-host interactions, in: Immunological Tolerance to Tissue Antigens ( N. W. Nisbet and M. W. Elves, eds.), pp. 299–313, Orthopaedic Hospital, Oswestry, England.Google Scholar
  20. Baldwin, R. W., and Pimm, M. V., 1978, Bcg in.tumor immunotherapy, Adv. Cancer Res. 28: 91.PubMedGoogle Scholar
  21. Baldwin, R. W., and Price, M. R., 1975, Neoantigen expression in chemical carcinogenesis, in: Cancer: A Comprehensive Treatise, Vol. 1 ( F. F. Becker, ed.), pp. 353–383, Plenum Press, New York.Google Scholar
  22. Baldwin, R. W., and Price, M. R., 1976, Immunobiology of rat neoplasia, Ann. N. Y. Acad. Sci. 276: 3.PubMedGoogle Scholar
  23. Baldwin, R. W., and Vose, B. M., 1974, The expression of a phase specific foetal antigen on rat embryo cells, Transplantation 18: 525.PubMedGoogle Scholar
  24. Baldwin, R. W., Barker, C. R., Embleton, M. J., Glaves, D., Moore, M., and Pimm, M. V., 1971a, Demonstration of cell-surface antigens on chemically induced tumors, Ann. N. Y. Acad. Sci. 177: 268.PubMedGoogle Scholar
  25. Baldwin, R. W., Glaves, D., Harris, J. R., and Price, M. R., 1971b, Tumor-specific antigens associated with aminoazo-dye-induced rat hepatomas, Transplant. Proc. 3: 1189.Google Scholar
  26. Baldwin, R. W., Glaves, D., and Pimm, M. V., 1971c, Tumor-associated antigens as expressions of chemically-induced neoplasia and their involvement in tumor-host interactions, in: Progress in Immunology ( B. Amos, ed.), pp. 907–920, Academic Press, New York.Google Scholar
  27. Baldwin, R. W., Glaves, D., Pimm, M. V., and Vose, B. M., 1972a, Tumour specific and embryonic antigen expression on chemically induced rat tumours, Ann. Inst. Pasteur (Paris) 122: 715.Google Scholar
  28. Baldwin, R. W., Glaves, D., and Vose, B. M., 1972b, Embryonic antigen expression in chemically induced rat hepatomas and sarcomas, Int. J. Cancer 10: 233.PubMedGoogle Scholar
  29. Baldwin, R. W., Harris, J. R., and Price, M. R., 1973, Fractionation of plasma membrane-associated tumour specific antigen from an aminoazo dye-induced rat hepatoma, Int. J Cancer 11: 385.PubMedGoogle Scholar
  30. Baldwin, R. W., Embleton, M. J., Price, M. R., and Vose, B. M., 1974a, Embryonic antigen expression on experimental rat tumours, Transplant. Rev. 20: 77.PubMedGoogle Scholar
  31. Baldwin, R. W., Glaves, D., and Vose, B. M., 1974b, Immunogenicity of embryonic antigens associated with chemically-induced rat tumours, Int. J Cancer 13: 135.Google Scholar
  32. Baldwin, R. W., Price, M. R., and Moore, V. E., 1978, Biochemical and immunological characterization of tumor specific antigens on chemically induced rat tumors, in: Biological Markers of Neoplasia: Basic and Applied Aspects ( R. W. Ruddon, ed.), pp. 11–24, Elsevier, New York.Google Scholar
  33. Baldwin, R. W., Embleton, M. J., and Pimm, M. V., 1979, Neoantigens in chemical carcinogenesis, in: Carcinogens: Identification and Mechanisms of Action ( A. C. Griffin and C. R. Shaw, eds.), pp. 365–379, Raven Press, New York.Google Scholar
  34. Bansal, S. C., Mark, R., Bansal, B. R., and Rhoads, J. E., 1978, Immunologic surveillance against chemically induced primary colon carcinoma in rats, j Natl. Cancer Inst. 60: 667.PubMedGoogle Scholar
  35. Bartlett, G. L., 1972, Effect of host immunity on the antigenic strength of primary tumors, J. Natl. Cancer Inst. 49: 493.PubMedGoogle Scholar
  36. Bartlett, G. L., and Zbar, B., 1972, Tumor-specific vaccine containing Mycobacterium bovis and tumor cells: Safety and efficiency, J Natl. Cancer Inst. 48: 1709.PubMedGoogle Scholar
  37. Basombrio, M. A., 1970, Search for common antigenicities among twenty-five sarcomas induced by methylcholanthrene, Cancer Res. 30: 2458.PubMedGoogle Scholar
  38. Basombrio, M. A., 1978, Letter to the Editor, Cancer Res. 38: 3568.PubMedGoogle Scholar
  39. Basombrio, M. A., and Prehn, R. T., 1972a, Search for common antigenicities between embryonic and tumoral tissue, Medicina (Buenos Aires) 32: 42.Google Scholar
  40. Basombrio, M. A., and Prehn, R. T., 1972b, Antigenic diversity of tumors chemically induced within the progeny of a single cell, Int. J. Cancer 10: 1.PubMedGoogle Scholar
  41. Basombrio, M. A., and Prehn, R. T., 1972c, Studies on the basis for diversity and time of appearance of antigens in chemically induced tumors, Natl. Cancer Inst. Monogr. 35: 117.PubMedGoogle Scholar
  42. Belnap, L. P., Cleveland, P. H., Colmerauer, M. E. M., Barone, R. M., and Pilch, Y. H., 1979, Immunogenicity of chemically induced murine colon cancers, Cancer Res. 39: 1174.PubMedGoogle Scholar
  43. Bendich, A., Borenfreund, E., and Stonehill, E. H., 1973, Protection of adult mice against tumor challenge by immunization with irradiated adult skin or embryo cells, J. Immunol. 111: 284.PubMedGoogle Scholar
  44. Bloom, E. T., 1970, Quantitative detection of cytotoxic antibodies against tumor-specific antigens of murine sarcomas induced by 3-methylcholanthrene, J. Natl. Cancer Inst. 45: 443.PubMedGoogle Scholar
  45. Bloom, E. T., and Hildemann, W. H., 1970, Mechanisms of tumor-specific enhancement versus resistance toward a methylcholanthrene-induced murine sarcoma, Transplantation 10: 321.PubMedGoogle Scholar
  46. Borberg, H., Oettgen, H. F., Choudry, K., and Beattie, E. J., 1972, Inhibition of established transplants of chemically induced sarcomas in syngeneic mice by lymphocytes from immunized donors, Int. J Cancer 10: 539.PubMedGoogle Scholar
  47. Borenfreund, E., Higgins, P. J., Steinglass, M., and Bendich, A., 1975, Properties and malignant transformation of established rat liver parenchymal cells in culture, J. Natl. Cancer Inst. 55: 375.PubMedGoogle Scholar
  48. Bowen, J. G., and Baldwin, R. W., 1975, Tumour-specific antigen related to rat histocompatibility antigens, Nature (London) 258: 75.Google Scholar
  49. Bowen, J. G., and Baldwin, R. W., 1979a, Tumour antigens and alloantigens. 1. Cross-reactivity of a rat tumour specific antigen with normal alloantigens of the host strain, Int. J. Cancer 23: 826.PubMedGoogle Scholar
  50. Bowen, J. G., and Baldwin, R. W., 1979b, Tumour antigens and alloantigens. II. Lack of association of rat hepatoma D23 specific antigen with ß-2-microglobulin, Int. J. Cancer 23: 833.PubMedGoogle Scholar
  51. Brown, J. P., Klitzman, J. M., and Hellström, K. E., 1977, A microassay for antibody binding to tumor cell surface antigens using 125I-labeled protein A from Staphylococcus aureus, J. Immunol. Methods 15: 57.Google Scholar
  52. Brown, J. P., Klitzman, J. M., Hellstrom, I., Nowinski, R. C., and Hellström, K. E., 1978, Antibody response of mice to chemically induced tumors, Proc. Nati Acad. Sci. Usa 74: 955.Google Scholar
  53. Brunson, K. W., Beattie, G., and Nicholson, G. L., 1978, Selection and altered properties of brain-colonising metastatic melanoma, Nature (London) 272: 543.Google Scholar
  54. Bubenik, J., Indrova, M., Nemckova, S., Malkovsky, M., Von Broen, B., Paler, V., and AnderllKova, J., 1978, Solubilized tumour-associated antigens of methylcholanthrene-induced mouse sarcomas. Comparative studies by in vitro sensitization of lymph-node cells, macrophage electrophoretic mobility assay and transplantation tests, Int. J. Cancer 21: 348.Google Scholar
  55. Burdick, J. F., Cohen, A. M., and Wells, S. A., 1973, A simplified isotopic antiglobulin assay: Detection of tumor-cell antigens, J. Natl. Cancer Inst. 50: 285.PubMedGoogle Scholar
  56. Burnet, F. M., 1970a, A certain symmetry: Histocompatibility antigens compared with immunocyte receptors, Nature (London) 226: 123.Google Scholar
  57. Burnet, F. M., 1970b, Immunological Surveillance, Pergamon Press, Oxford.Google Scholar
  58. Carbone, G., Invernizzi, G., Meschini, A., and Parmiani, G., 1978, In vitro and in vivo expression of original and foreign H-2 antigens and of the tumor-associated transplantation antigen of a murine fibrosarcoma, Int. J. Cancer 21: 85.Google Scholar
  59. Castro, J. E., Lance, E. M., Medawar, P. B., Zanelli, J., and Hunt, R., 1973, Foetal antigens and cancer, Nature (London) 243: 225.Google Scholar
  60. Chism, S., Burton, R., and Warner, N. L., 1975, Lymphocyte activation in vitro to murine onto-foetal antigens, Nature (London) 257: 594.Google Scholar
  61. Chism, S., Burton, R., and Warner, N. L., 1976, In vitro induction of tumorspecific immunity. II. Activation of cytotoxic lymphocytes to murine oncofetal antigens, J Natl. Cancer Inst. 57: 377.Google Scholar
  62. Cikes, M., Friberg, S. And Klein, G., 1973, Progressive loss of H-2 antigens with concomitant increase of cell surface antigen(s) determined by Moloney leukemia virus in cultured murine lymphomas, J Natl. Cancer Inst. 50: 347.PubMedGoogle Scholar
  63. Cleveland, P. H., Belnap, L. P., Knotts, F. B., Nayak, S. K., Baird, S. M., and Pilch, Y. H., 1979, Tumor-associated antigens of chemically-induced murine tumors: The emergence of MuLV and fetal antigens after serial passage in culture, Int. J. Cancer 23: 380.PubMedGoogle Scholar
  64. Coggin, J. H., and Ambrose, K. R., 1979, Embryonic and fetal determinants on virally and chemically induced tumors, Methods Cancer Res. 18: 371.Google Scholar
  65. Coggin, J. H., and Anderson, N. G., 1974, Cancer differentiation and embryonic antigens: Some central problems, Adv. Cancer Res. 19: 106.Google Scholar
  66. Coggin, J. H., Ambrose, K. R., and Anderson, N. G., 1970, Fetal antigen capable of inducing transplantation immunity against SV40 hamster tumor cells, j Immunol. 105: 524.PubMedGoogle Scholar
  67. Coggin, J. H., Ambrose, K. R., Bellomy, B. B., and Anderson, N. G., 1971, Tumor immunity in hamsters immunized with fetal tissues, J. Immunol. 107: 526.PubMedGoogle Scholar
  68. Cohen, A. M., Millar, R. C., and Ketcham, A. S., 1972, Host immunity to a growing transplanted methylcholanthrene-induced guinea pig sarcoma, Cancer Res. 32: 2421.PubMedGoogle Scholar
  69. Collavo, D., Biasi, G., Zanovello, P., Chieco-Bianchi, L., and Colombatti, A., 1979, Role of the H-2 complex in the T-cell-mediated cytotoxicity to Moloney murine sarcoma virus (M-Msv)induced tumors, in: Current Trends in Tumor Immunology ( S. Ferrone, S. Gorini, R. B. Herberman, and R. A. Reisfeld, eds.), pp. 309–322, Garland Stpm Press, New York.Google Scholar
  70. Cornain, S., Carnaud, D., Silverman, D., Klein, E., and Rajewsky, M. F., 1975, Spleen-cell reactivity against transplanted neurogenic rat tumors induced by ethylnitrosourea: Uncovering of tumor specificity after removal of complement-receptor-bearing lymphocytes, Int. j Cancer 16: 301.PubMedGoogle Scholar
  71. Deleo, A. B., Shiku, H., Takahashi, T., John, M., and Old, L. J., 1977, Cell surface antigens of chemically-induced sarcomas in the mouse, J. Exp. Med. 146: 720.PubMedGoogle Scholar
  72. Deleo, A. B., Shiku, H., Takahashi, T., and Old, L. J., 1978, Serological definition of cell surface antigens of chemically induced sarcomas of inbred mice, in: Biological Markers of Neoplasia: Basic and Applied Aspects ( R. W. Ruddon, ed.), pp. 25–34, Elsevier, New York.Google Scholar
  73. Deleo, A. B., Jay, G., Appella, E., Dubois, G. C., Law, L. W., and Old, L. J., 1979, Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse, Proc. Natl. Acad. Sci. Usa 76: 2420.PubMedGoogle Scholar
  74. Delorme, E. J. And Alexander, P., 1964, Treatment of primary fibrosarcoma in the rat with immune lymphocytes, Lancet 1: 117.Google Scholar
  75. Dennick, R. G., Price, M. R., and Baldwin, R. W., 1979, Modification of the immunogenicity and antigenicity of rat hepatoma cells. II. Mild heat treatment, Br. j Cancer 39: 630.PubMedCentralPubMedGoogle Scholar
  76. Doherty, P. C., Blanden, R. V., and Zinkernagel, R. M., 1976, Specificity of virus-immune effector T cells for H-2K or H-2D compatible reactions: Implications for H-antigen diversity, Transplant. Rev. 29: 89.PubMedGoogle Scholar
  77. Drinkwater, N. R., Miller, J. A., Miller, E. C., and Yang, N.-C., 1978, Covalent intercalative binding to Dna in relation to the mutagenicity of hydrocarbon epoxides and N-acetoxy-2-acetylaminofluorene, Cancer Res. 38: 3247.PubMedGoogle Scholar
  78. Duff, R., and Rapp, F., 1970, Reactions of serum from pregnant hamsters with surface of cells transformed by SV40, j Immunol. 105: 521.PubMedGoogle Scholar
  79. Economou, G., Takeiki, N., and Boone, C., 1977, Common tumor rejection antigens in methylcholanthrene-induced squamous cell carcinomas in mice detected by tumor protection and a radioisotopic footpad assay, Cancer Res. 37: 37.PubMedGoogle Scholar
  80. Embleton, M. J., 1979, Antigenic changes associated with liver carcinogenesis, J. Toxicol. Environ. Health 5: 453.PubMedGoogle Scholar
  81. Embleton, M. J., and Baldwin, R. W., 1979, Tumour-related antigen specificities associated with 3-methylcholanthrene-treated rat embryo cells, Int. J. Cancer 23: 840.PubMedGoogle Scholar
  82. Embleton, M. J., and Baldwin, R. W., 1980, Antigenic changes in chemical carcinogenesis, Br. Med. Bull. 36: 83.PubMedGoogle Scholar
  83. Embleton, M. J., and Heidelberger, C., 1972, Antigenicity of clones of mouse prostate cells transformed in vitro, Int. J. Cancer 9: 8.Google Scholar
  84. Embleton, M. J., and Heidelberger, C., 1975, Neoantigens on chemically transformed clones C3H mouse embryo cells, Cancer Res. 35: 2049.PubMedGoogle Scholar
  85. Embleton, M. J., and Iype, P. T., 1978, Surface antigens on rat liver epithelial cells grown in medium containing foetal bovine serum, Br. J. Cancer 38: 456.PubMedCentralPubMedGoogle Scholar
  86. Faragi, R. P., 1974, In vitro demonstration of altered antigenicity of metastases from a primary methylcholanthrene-induced sarcoma, Surgery 76: 469.Google Scholar
  87. Farber, E., 1973, Hyperplastic liver nodules, Methods Cancer Res. 7: 345.Google Scholar
  88. Farber, E., 1976, The pathology of experimental liver cell cancer in: Liver Cell Cancer (H. M. Cameron, D. A. Linsell, and G. P. Warwick, eds.), pp. 243–277, Elsevier, Amsterdam.Google Scholar
  89. Fialkow, P. J., 1976, Clonal origin of human tumors, Biochim. Biophys. Acta 458: 283.PubMedGoogle Scholar
  90. Fialkow, P. J., 1979, Clonal origin of human tumors, Annu. Rev. Med. 30: 135.Google Scholar
  91. Fidler, I. J., and Kripke, M. L., 1977, Metastasis results from pre-existing variant cells within a malignant tumor, Science 197: 893.PubMedGoogle Scholar
  92. Foley, E. J., 1953, Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin, Cancer Res. 13: 835.PubMedGoogle Scholar
  93. Forni, G., Shevach, E. M., and Green, I., 1976, Mutant lines of guinea pig L2C leukemia, J. Exp. Med. 143: 1067.PubMedGoogle Scholar
  94. Foulds, L., 1965, Multiple etiologic factors in neoplastic development, Cancer Res. 25: 1339.PubMedGoogle Scholar
  95. Garrido, F., Schirrmacher, V., and Festenstein, H., 1976, H-2-like specificities of foreign haplotypes appearing on a mouse sarcoma after vaccinia virus infection, Nature (London) 259: 228.Google Scholar
  96. Germain, R. W., Dore, N. F., and Benacerraf, B., 1975, Inhibition of T-lymphocyte mediated tumor-specific lysis by alloantisera directed against the H-2 serological specificities of the tumor, J Exp. Med. 142: 1023.PubMedCentralPubMedGoogle Scholar
  97. Girardi, A. J., and Reppucci, P., 1972, The relationship of hamster fetal antigen to SV40 tumor-specific transplantation antigen, in: Embryonic and Fetal Antigens in Cancer, Vol. 2 ( N. G. Anderson, J. S. Coggin, E. Cole, and J. W. Holleman, eds.), pp. 167–170, Usaec, Oak Ridge.Google Scholar
  98. Globerson, A., and Feldman, M., 1964, Antigenic specificity of benzo[a]pyrene-induced sarcomas, J. Natl. Cancer Inst. 32: 1229.PubMedGoogle Scholar
  99. Gooding, L. R., 1976, Expression of early fetal antigens on transformed mouse cells, Cancer Res. 36: 3499.PubMedGoogle Scholar
  100. Gordon, J., 1965, Isoantigenicity of liver tumours induced by an azo dye, Br. J. Cancer 19: 387.PubMedCentralPubMedGoogle Scholar
  101. Grant, J. P., Landisch, S., and Wells, S. A., 1974a, Immunologic similarities between fetal cell antigens and tumor cell antigens in guinea pigs, Cancer 33: 376.PubMedGoogle Scholar
  102. Grant, J. P., Bigner, D. D., Fischinger, P. J., and Bolognesi, D. P., 1974b, Expression of murine leukemia virus structural antigens on the surface of chemically induced murine sarcomas, Proc. Natl. Acad. Sci. Usa 71: 5037.PubMedGoogle Scholar
  103. Greaves, M. F., 1979, Tumour markers, phenotypes and maturation arrest in malignancy: A cell selection hypothesis, in: Tumour Markers: Impact and Prospects ( E. Boelsma and Ph. Rümke, eds.), pp. 201–211, Elsevier, Amsterdam.Google Scholar
  104. Griffin, M., and Kizer, D. E., 1978, Purification and quantitation of preneoplastic antigen from hyperplastic nodules and normal liver, Cancer Res. 38: 1136.PubMedGoogle Scholar
  105. Gunn, B., Embleton, M. J., Middle, J. G., and Baldwin, R. W., 1980, Monoclonal antibody against a naturally occurring rat mammary carcinoma, Int. J. Cancer 26: 325.PubMedGoogle Scholar
  106. Haase, P., Cowen, D. M., Knowles, J. C., and Cooper, E. H., 1973, Evaluation of dimethylhydrazineinduced tumours in mice as a model system for colorectal cancer, Br. J. Cancer 28: 530.PubMedCentralPubMedGoogle Scholar
  107. Haddow, A., 1974, Molecular repair, wound healing and carcinogenesis: Tumor production a possible overhealing? Adv. Cancer Res. 16: 181.Google Scholar
  108. Halliday, W. J., 1971, Blocking effect of serum frum tumor-bearing animals on macrophage migration inhibition with tumor antigens, J. Immunol. 106: 855.PubMedGoogle Scholar
  109. Halliday, W. J., and Miller, S., 1972, Leukocyte adherence inhibition: A simple test for cell-mediated tumour immunity and serum blocking factors, Int. J Cancer 8: 477.Google Scholar
  110. Halliday, W. J., and Webb, M., 1969, Delayed hypersensitivity to chemically induced tumors in mice and correlation with an in vitro test, J. Natl. Cancer Inst. 43: 141.PubMedGoogle Scholar
  111. Hannant, D., Bowen, J. G., Dennick, R. G., Price, M. R., and Baldwin, R. W., 1979, Purification of tumour specific antigens—Problems of affinity, avidity and resolution, in: Affinity Chromatography and Molecular Interactions, Vol. 86 ( J. M. Egly, ed.), p. 477, Inserm, Paris.Google Scholar
  112. Hannant, D., Bowen, J. G., Price, M. R., and Baldwin, R. W., 1980, Radioiodination of rat hepatoma specific antigens and retention of serological reactivity, Br. J. Cancer, 41: 716.PubMedCentralPubMedGoogle Scholar
  113. Harder, F. H., and McKhann, C. F., 1968, Demonstration of cellular antigens on sarcoma cells by an indirect 125í-labelled antibody technique, J. Natl. Cancer Inst. 40: 231.PubMedGoogle Scholar
  114. Harris, J. R., Price, M. R., and Baldwin, R. W., 1973, The purification of membrane-associated tumour antigens by preparative polyacrylamide gel electrophoresis, Biochim. Biophys. Acta 311: 600.PubMedGoogle Scholar
  115. Haywood, G. R., and McKhann, C. F., 1971, Antigenic specificities on murine sarcoma cells, J. Exp. Med. 133: 1171.PubMedCentralPubMedGoogle Scholar
  116. Heidelberger, C., 1975, Chemical carcinogenesis, Annu. Rev. Biochem. 44: 79.Google Scholar
  117. Hellström, I., Hellström, K. E., and Pierce, G. E., 1968, In vitro studies of immune reactions against autochthonous and syngeneic mouse tumors induced by methylcholanthrene and plastic discs, Int. J. Cancer 3: 467.Google Scholar
  118. Hellström, I., Hellström, K. E., and Shantz, G., 1976, Demonstration of tumor-associated immunity with a leukocyte adherence inhibition (Lai) assay, Int. J. Cancer 18: 354.PubMedGoogle Scholar
  119. Hellström, K. E., and Hellström, I., 1969, Cellular immunity against tumor antigens, Adv. Cancer Res. 12: 167.PubMedGoogle Scholar
  120. Hellström, K. E., Hellström, I., and Brown, J. P., 1978, Unique and common tumor-specific transplantation antigens of chemically induced mouse sarcomas, Int. J. Cancer 21: 317.Google Scholar
  121. Herberman, R. B., and Holden, H. T., 1978, Natural cell-mediated immunity, Adv. Cancer Res. 27: 305.PubMedGoogle Scholar
  122. Herberman, R. B., Kay, H. D., Bonnard, G. D., Ortaldo, J. R., Fagnani, R., Djeu, J. Y., and Holden, H. T., 1979, Characteristics of effector cells of natural and antibody-dependent cytotoxicity and factors affecting their expression, in: Current Trends in Tumor Immunology ( S. Ferrone, S. Gorini, R. B. Herberman, and R. A. Reisfeld, eds.), pp. 61–70, Garland Stpm Press, New York.Google Scholar
  123. Hirai, H., 1979, Model systems of Afp and Cea expression, Methods Cancer Res. 18: 39.Google Scholar
  124. Holmes, E. C., Morton, D. L., Schidlowsky, G., and Trahan, E., 1971, Cross-reacting tumor-specific transplantation antigens in methylcholanthrene-induced guinea pig sarcomas, J. Natl. Cancer Inst. 46: 693.PubMedGoogle Scholar
  125. Hopper, D., P1MM, M. V., and Baldwin, R. W., 1975, Methanol extraction residue of Bcg in the treatment of transplanted rat tumours, Br. J. Cancer 31: 176.PubMedCentralPubMedGoogle Scholar
  126. Invernizzi, G., and Parmiani, G., 1975, Tumour-associated transplantation antigens of chemically induced sarcomata cross-reacting with allogeneic histocompatibility antigens, Nature (London) 254: 713.Google Scholar
  127. Irie, R. F., Iris, K., and Morton, D. L., 1974, Natural antibody in human serum to a neoantigen in human cultured cells growing in fetal bovine serum, J. Natl. Cancer Inst. 52: 1051.PubMedGoogle Scholar
  128. Ishidate, M., 1974, Antigen specificity of different cell lines of rat ascites hepatoma originating in the same individual, Gann Monogr. Cancer Res. 16: 195.Google Scholar
  129. Isojima, S., Yagi, Y., and Pressman, D., 1969, Antigens common to rat hepatomas induced with 2-acetylaminofluorene, Cancer Res. 29: 140.PubMedGoogle Scholar
  130. Iype, P. T., Baldwin, R. W., and Glaves, D., 1973, Cell surface antigenic changes induced in normal adult rat liver cells by carcinogen treatment in vitro, Br. J Cancer 27: 128.Google Scholar
  131. Jamasbi, R. J., and Nettesheim, P., 1977, Demonstration of cross-reacting tumor rejection antigens in chemically induced respiratory tract carcinomas in rats, Cancer Res. 37: 4059.PubMedGoogle Scholar
  132. Jeffcoate, W. J., and Rees, L. H., 1978, Adrenocorticotropin and related peptides in non-endocrine tumors, Curr. Top. Exp. Endocrinol. 3: 57.PubMedGoogle Scholar
  133. Johnson, S., 1968, The effect of thymectomy and of the dose of 3-methylcholanthrene on the induction and antigenic properties of sarcomas in C57 B1 mice, Br. J. Cancer 22: 93.PubMedCentralPubMedGoogle Scholar
  134. Katz, D. H., and Benacerraf, B., 1975, The function and interrelationship of T cell receptors, Ir genes and other histocompatibility gene products, Transplant. Rev. 22: 175.PubMedGoogle Scholar
  135. Kerbel, R. S., 1979a, Implications of immunological heterogeneity of tumours, Nature (London) 280: 358.Google Scholar
  136. Kerbel, R. S., 1979b, Immunologic studies of membrane mutants of a highly metastatic murine tumor, Am. J. Pathol. 97: 609.PubMedGoogle Scholar
  137. Klein, G., 1973, Tumor immunology, Transplant. Proc. 5: 31.PubMedGoogle Scholar
  138. Klein, G., and Klein, E., 1975, Are methylcholanthrene-induced sarcoma-associated, rejection inducing (Tsta) antigens, modified forms of H-2 or linked determinants?, Int. J. Cancer 15: 879.PubMedGoogle Scholar
  139. Klein, G., Sjögren, H. O., Klein, E., and HellstrÖM, K. E., 1960, Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host, Cancer Res. 20: 1561.PubMedGoogle Scholar
  140. Klein, J., 1975, Biology of the Mouse Histocompatibility-2 Complex, Springer, Berlin.Google Scholar
  141. Kripke, M. L., Grays, E., and Fidler, I. J., 1978, Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin, Cancer Res. 38: 2962.PubMedGoogle Scholar
  142. Kronman, B. S., Rapp, H. J., and Borsos, T., 1969, Tumor-specific antigens: Detection by local transfer of delayed skin hypersensitivity, J. Natl. Cancer Inst. 43: 869.PubMedGoogle Scholar
  143. Lando, P., Blomberg, F., Raftell, M., Berzins, K., and Perlmann, P., 1977, Complement dependent cytotoxicity against hepatoma cells mediated by IgM antibodies in the serum from tumor bearing rats, Scand. j Immunol. 6: 1081.PubMedGoogle Scholar
  144. Lappé, M. A., 1969, Tumour specific transplantation antigens: Possible origin in pre-malignant lesions, Nature (London) 223: 82.Google Scholar
  145. Lausch, R. N., and Rapp, R., 1974, Tumor-specific antigens and re-expression of fetal antigens in mammalian cells, Prog. Exp. Tumor Res. 19: 45.PubMedGoogle Scholar
  146. Law, L. W., and Appella, E., 1975, Studies of soluble transplantation antigens and tumor antigens, in: Cancer: A Comprehensive Treatise, Vol. 4 ( F. F. Becker, ed.), pp. 135–157, Plenum Press, New York.Google Scholar
  147. Law, L. W., Appella, E., and Dubois, G. C., 1978, Immunogenic properties of solubilized, partially purified tumor rejection antigen (Tsta) from a chemically induced sarcoma, in: Biological Markers of Neoplasia: Basic and Applied Aspects ( R. W. Ruddon, ed.), pp. 35–43, Elsevier, New York.Google Scholar
  148. Law, L. W., Dubois, G. C., Rogers, M. J., Appella, E., Pierotti, M. A., and Parmiani, G., 1980, Tumor rejection activity of antigens isolated from membranes of a methylcholanthrene-induced sarcoma, C-1, bearing alien H-2 antigens, Transplant. Proc. 7: 46.Google Scholar
  149. Lawley, P. D., 1980, Dna as a target of alkylating carcinogens, Br. Med. Bull. 36: 19.PubMedGoogle Scholar
  150. Leffell, M. S., and Coggin, J. H., 1977, Common transplantation antigens on methylcholanthreneinduced murine sarcomas detected by three assays of tumor rejection, Cancer Res. 37: 4112.PubMedGoogle Scholar
  151. Lejniva, O. M., Zilber, L. A., and Ievleva, E. S., 1965, Humoral antibodies to methylcholanthrene sarcomata detected by a fluorescent technique, Nature (London) 206: 1163.Google Scholar
  152. LE Mevel, B. P., and Wells, S. A., 1973, Foetal antigens cross-reactive with tumor-specific transplantation antigens, Nature New Biol. 244: 183.Google Scholar
  153. Lennox, E., Cohn, J., and Lowe, T., 1980, Syngeneic monoclonal antibodies to a methylcholanthreneinduced mouse sarcoma, Transplant. Proc. 7: 95.Google Scholar
  154. Leonard, E. J., 1973, Cell surface antigen movement: Induction in hepatoma cells by antitumor antibody, J. Immunol. 110: 1167.Google Scholar
  155. Leonard, E. J., Meltzer, M. S., BoRsos, T., and Rapp, H. J., 1972, Properties of soluble tumor-specific antigen solubilized by hypertonic potassium chloride, Natl. Cancer Inst. Monogr. 35: 129.PubMedGoogle Scholar
  156. Leonard, E. J., Richardson, A. K., Hardy, A. S., and Rapp, H. J., 1975, Extraction of tumor-specific antigen from cells and plasma membranes of line-10 hepatoma, J. Natl. Cancer Inst. 55: 73.PubMedGoogle Scholar
  157. Mann, D. L., 1972, The effect of enzyme inhibitors on the solubilization of HL-A antigens with 3M Kci, Transplantation 14: 398.PubMedGoogle Scholar
  158. Martin, F., Martin, M., Lagneau, A., Borcles, M., and Knobels, S., 1976, Circulating antibodies in rats bearing grafted colon carcinoma, Cancer Res. 36: 3039.PubMedGoogle Scholar
  159. Martin, W. J., Esser, E., Cotton, W. G., and Rice, J. M., 1973, Derepression of alloantigens in malignancy. Evidence for tumor susceptibility alloantigens and for possible self-reactivity of lymphoid cells active in the microcytotoxicity assay, Br. J. Cancer Suppl. 28: 48.Google Scholar
  160. Meltzer, M. S., Leonard, E. J., Rapp, H. J., and Borsos, T., 1971, Tumor-specific antigen solubilized by hypertonic potassium chloride, J. Natl. Cancer Inst. 47: 703.PubMedGoogle Scholar
  161. Ménard, S., Colnaghi, M. I., and Della Porta, G., 1973, In vitro demonstration of tumor-specific common antigens and embryonal antigens in murine fibrosarcomas induced by 7,12-dimethylbenz[a]anthracene, Cancer Res. 33: 478.Google Scholar
  162. Milas, L., and Scott, M. T., 1977, Antitumor activity of Corynebacterium parvum, Adv. Cancer Res. 26: 257.Google Scholar
  163. Miller, E. C., Kadlubar, F. F., Miller, J. A., Pitot, H. C., and Drinkwater, N. R., 1979, The N-hydroxy metabolites of N-methyl-4-aminoazobenzene and related dyes as proximate carcinogens in the rat and mouse, Cancer Res. 39: 3411.PubMedGoogle Scholar
  164. Miller, J. A., 1979, Remarks on chemicals and chemical carcinogenesis, in: Carcinogens: Identification and Mechanisms of Action ( A. C. Griffin and C. R. Shaw, eds.), pp. 455–459, Raven Press, New York.Google Scholar
  165. Minami, A., Mizushima, Y., Takeichi, N., Hosokawa, M., and Kobayashi, H., 1979, Dissociation of anti-tumor immune responses in rats immunized with solubilized tumor-associated antigens from a methylcholanthrene induced fibrosarcoma, Int. J. Cancer 23: 358.Google Scholar
  166. Möller, G., and Möller, E., 1976, The concept of immunological surveillance against neoplasia, Transplant. Rev. 28: 3.PubMedGoogle Scholar
  167. Mondal, S., Type, P. T., Griesbach, L. M., and Heidelberger, C., 1970, Antigenicity of cells derived from mouse prostate after malignancy transformation in vitro by carcinogenic hydrocarbons, Cancer Res. 30: 1593.PubMedGoogle Scholar
  168. Mondal, S., Embleton, M. J., Marquardt, H., and Heidelberger, C., 1971, Production of variants of decreased malignancy and antigenicity from clones transformed in vitro by methylcholanthrene, Int. J. Cancer 8: 410.PubMedGoogle Scholar
  169. Montesano, R., Saint-Vincent, L., and Tomatis, L., 1973, Malignant transformation in vitro of rat liver cells by dimethylnitrosamine and N-methyl-N’-nitro-N-nitrosoguanidine, Br. J. Cancer 28: 215.PubMedCentralPubMedGoogle Scholar
  170. Morton, D. L., Goldman, L., and Wood, D., 1965, Tumor specific antigenicity of methylcholanthrene (Mca) and dibenzanthracene (Dba) induced sarcomas of inbred guinea pigs, Fed. Proc. Fed. Am. Soc. Exp. Biol. 24: 684.Google Scholar
  171. Müller, M., 1968, Versuche zur Erzeugung einer Transplantationsimmunität gegen oAminoazotoluol-Hepatome bei syngenen and F1Hybrid-Mäusen, Arch. Geschwulstforsch. 31: 235.PubMedGoogle Scholar
  172. Murgita, R. A., Goidl, E. A., Kontianen, S., and Wigzell, H., 1977, a-Fetoprotein induces suppressor T cells in vitro, Nature (London) 267: 257.Google Scholar
  173. Natori, T., Law, L. W., and Appella, E., 1977, Biological and biochemical properties of Nonidet P-40-solubilized and partially purified tumor-specific antigens of the transplantation type from plasma membranes of a methylcholanthrene-induced sarcoma, Cancer Res. 37: 3406.PubMedGoogle Scholar
  174. Natori, T., Law, L. W., and Appella, E., 1978, Immunochemical evidence of a tumor-specific surface antigen obtained by detergent solubilization of the membranes of a chemically induced sarcoma, Meth. A, Cancer Res. 38: 359.PubMedGoogle Scholar
  175. Nelson, K. A., Sjögren, H. O., and Rosengren, J. E., 1977, Detection of antibodies to embryonic antigens in sera of multiparous or colon tumor-bearing rats by a new indirect immunofluorescence assay, Int. J. Cancer 20: 227.PubMedGoogle Scholar
  176. Nicolson, G. L., 1976, Transmembrane control of the receptors on normal and tumour cells. II. Surface changes associated with transformation and malignancy, Biochim. Biophys. Acta 458: 1.PubMedGoogle Scholar
  177. Nielsen, J. T., and Chapman, V. W., 1977, Electrophoretic variation for X-chromosome-linked phosphoglycerate kinase (Pck-1) in the mouse, Genetics 87: 319.PubMedGoogle Scholar
  178. Nowell, P. C., 1976, The clonal evolution of tumor cell populations, Science 194: 23.PubMedGoogle Scholar
  179. Odell, W. D., and Wolfson, A., 1975, Ectopic hormone secretion by tumors, in: Cancer: A Comprehensive Treatise, Vol. 3 ( F. F. Becker, ed.), pp. 81–119, Plenum Press, New York.Google Scholar
  180. Oettgen, H. F., Old, L. J., McLean, E. P., and Carswell, E. A., 1968, Delayed hypersensitivity and transplantation immunity elicited by soluble antigens of chemically induced tumours in inbred guinea pigs, Nature (London) 220: 295.Google Scholar
  181. Old, L. J., and Boyse, E. A., 1965, Antigens of tumors and leukemias induced by viruses, Fed. Proc. Fed. Am. Soc. Exp. Biol. 24: 1009.Google Scholar
  182. Old, L. J., and Stockert, E., 1977, Immunogenetics of cell surface antigens 6f mouse leukemia, Annu. Rev. Genet. 11: 127.Google Scholar
  183. Old, L. J., Boyse, E. A., Clarke, D. A., and Carswell, E. A., 1962, Antigenic properties of chemically induced tumors, Ann. N. Y. Acad. Sci. 101: 80.Google Scholar
  184. Ortaldo, J. R., Ting, C. C., and Herberman, R. B., 1974, Modulation of fetal antigen(s) in mouse leukemia cells, Cancer Res. 34: 1366.PubMedGoogle Scholar
  185. Parker, G. A., and Rosenberg, S. A., 1977, Cross-reacting antigens in chemically induced sarcomas are fetal determinants, J. Immunol. 118: 1590.PubMedGoogle Scholar
  186. Parker, G. A., Hyatt, C., and Rosenberg, S. A., 1977, Normal adult murine cells in tissue culture express fetal antigens, Transplantation 23: 161.PubMedGoogle Scholar
  187. Parmiani, G., and Invernizzi, G., 1975, Alien histocompatibility determinants on the cell surface of sarcomas induced by methylcholanthrene, Int. J. Cancer 16: 756.PubMedGoogle Scholar
  188. Parmiani, G., Colnaghi, M. I., and Della Porta, G., 1971, Immunodepression during urethane and N-nitrosomethylurea leukaemogenesis in mice, Br. J. Cancer 25: 354.PubMedCentralPubMedGoogle Scholar
  189. Parmiani, G., Ballinari, D., Carbone, G., Invernizzi, G., and Pierotti, M. A., 1979, Tumor-associated transplantation antigens and alien H-2 antigens on chemically induced sarcomas, in: Current Trends in Tumor Immunology ( S. Ferrone, S. Gorini, R. B. Herberman, and R. A. Reisfeld, eds.), pp. 323–333, Garland Stpm Press, New York.Google Scholar
  190. Pasternak, G., 1963, Die unterschiedliche Reaktionsfähigkeit zweier Mäuseinzuchstämme gegen spezifische Antigene transplantabler Carcinogentumoren, Acta Biol. Med. Ger. 10: 572.PubMedGoogle Scholar
  191. Pasternak, G., Graffi, A., Hoffmann, F., and Horn, K.-H., 1964, Resistance against carcinomas of the skin induced by dimethylbenzanthracene (Dmba) in mice of the strain Xvii/Bin, Nature (London) 203: 307.Google Scholar
  192. Pasternak, G., Hoffmann, F., and Graffi, A., 1966, Growth of diethylnitrosamine-induced lung tumours in syngeneic mice specifically pre-treated with X-ray killed tumour tissue, Folia Biol. (Prague) 12: 299.Google Scholar
  193. Pasternak, G., Von Broen, B., Schlott, B., Albrecht, S., Gryschek, G., Reinhofer, J., and Thuy, L. T., 1979, Lymphocyte reactivity in animal and human tumor systems to fetal antigens as detected by Mem, Lai and Lmi techniques, in: Cell Electrophoresis: Clinical Application and Methodology ( A. W. Preece and D. Sabolovic, eds.), pp. 225–234, Elsevier, Amsterdam.Google Scholar
  194. Pasternak, G., Schlott, B., Albrecht, S., Gryschek, G., Reinhöfer, J. and Von Broen, B., 1980, Cellular immune reactions to foetal extracts in patients with malignant tumours, in: Biology of the Cancer Cell ( K. Letnansky, ed.), pp. 173–178, Kugler, Amsterdam.Google Scholar
  195. Pellis, N. R., and Kahan, B. D., 1975, Specific tumor immunity induced with soluble materials: Restricted range of antigen dose and of challenge tumor load for immunoprotection, J. Immunol. 115: 1717.PubMedGoogle Scholar
  196. Pellis, N. R., Tom, B. J., and Kahan, B. D., 1974, Tumor-specific and allospecific immunogenicity of soluble extracts from chemically induced murine sarcomas, J. Immunol. 113: 708.PubMedGoogle Scholar
  197. Phillips, E. R., and Perdue, J. F., 1977, Immunological identification of fetal calf serum-derived proteins on the surfaces of cultured transformed and untransformed rat cells, Int. J. Cancer 20: 798.PubMedGoogle Scholar
  198. Pimm, M. V., and Baldwin, R. W., 1977, Antigenic differences between primary methylcholanthreneinduced rat sarcomas and post-surgical recurrences, Int. J. Cancer 20: 37.PubMedGoogle Scholar
  199. Pimm, M. V., Embleton, M. J., and Baldwin, R. W., 1980, Multiple antigenic specificities within primary 3-methylcholanthrene-induced rat sarcomas and metastases, Int. J. Cancer 25: 621.PubMedGoogle Scholar
  200. Pitot, H. C., 1979, Biological and enzymatic events in chemical carcinogenesis, Anna. Rev. Med. 30: 25.Google Scholar
  201. Poste, G., and Fidler, I. J., 1980, The pathogenesis of cancer metastasis, Nature (London) 283: 139.Google Scholar
  202. Prehn, R. T., 1960, Tumor-specific immunity to transplanted dibenz[a,h]anthracene-induced sarcomas, Cancer Res. 20: 1614.Google Scholar
  203. Prehn, R. T., 1967, The significance of tumor-distinctive histocompatibility antigens, in: Cross Reacting Antigens and Neoantigens (J. J. Trentin, ed.), pp. 105–117, Williams & Wilkins, Baltimore.Google Scholar
  204. Prehn, R. T., 1970, Analysis of antigenic heterogeneity within individual 3-methylcholanthreneinduced mouse sarcomas, J. Natl. Cancer Inst. 45: 1039.PubMedGoogle Scholar
  205. Prehn, R. T., 1975, Relationship of tumor immunogenicity to concentration of the oncogen, J. Natl. Cancer Inst. 55: 189.PubMedGoogle Scholar
  206. Prehn, R. T., and Main, J. M., 1957, Immunity to methylcholanthrene-induced sarcomas, J. Natl. Cancer Inst. 18: 769.PubMedGoogle Scholar
  207. Preston, V. E., and Price, M. R., 1977, Partial purification of a plasma membrane-associated tumour-specific antigen from a rat sarcoma by using immunoadsorbent column chromatography, Biochem. Soc. Trans. 5: 123.PubMedGoogle Scholar
  208. Price, M. R., 1978, A microassay for the detection of tumour-specific complement dependent serum cytotoxicity against a chemically induced rat hepatoma, Transplantation 25: 224.PubMedGoogle Scholar
  209. Price, M. R., and Baldwin, R. W., 1974a, Preparation of aminoazo dye-induced rat hepatoma membrane fractions retaining tumour specific antigen, Br. J. Cancer 30: 382.Google Scholar
  210. Price, M. R., and Baldwin, R. W., 1974b, Immunogenic properties of rat hepatoma subcellular fractions, Br. J. Cancer 30: 394.PubMedCentralPubMedGoogle Scholar
  211. Price, M. R., and Baldwin, R. W., 1977 a, Tumour-specific complement-dependent serum cytotoxicity against a chemically-induced rat hepatoma, Int. J. Cancer 20: 284.Google Scholar
  212. Price, M. R., and Baldwin, R. W., 1977b, Shedding of tumor cell surface antigens, in: Dynamic Aspects of Cell Surface Organization ( G. Poste and G. L. Nicolson, eds.), pp. 423–471, Elsevier, Amsterdam.Google Scholar
  213. Price, M. R., Preston, V. E., Robins, R. A., Zoller, M., and Baldwin, R. W., 1978, Induction of immunity to chemically-induced tumours by cellular or soluble antigens, Cancer Immunol. Immunother. 3: 247.Google Scholar
  214. Price, M. R., Dennick, R. G., Hannant, D., and Al-Sheikly, A. W. A. R., 1979a, Detection, isolation and immunogenicity of rat tumour antigens, in: Cell Electrophoresis: Clinical Application and Methodology ( A. W. Preece and D. Sablovic, eds.), pp. 247–254, Elsevier, Amsterdam.Google Scholar
  215. Price, M. R., Dennick, R. G., and Law, L. W., 1979b, Effect of heat and glutaraldehyde upon the immunogenicity of Meth A sarcoma cells, Br. J. Cancer 40: 663.PubMedCentralPubMedGoogle Scholar
  216. Price, M. R., Dennick, R. G., Robins, R. A., and Baldwin, R. W., 1979c, Modification of the immunogenicity and antigenicity of rat hepatoma cells. I. Cell-surface stabilization with glutaraldehyde, Br. J. Cancer 39: 621.PubMedCentralPubMedGoogle Scholar
  217. Price, M. R., HöFfken, K., and Baldwin, R. W., 1979d, Activity of syngeneic complement for revealing antibody-induced cytotoxicity against a rat hepatoma, Transplantation 28: 140.PubMedGoogle Scholar
  218. Price, M. R., Moore, V. E., and Baldwin, R. W., 1979e, Biochemical aspects of tumor-specific antigens, in: Current Trends in Tumor Immunology ( S. Ferrone, S. Gorini, R. B. Herberman, and R. A. Reisfeld, eds.), pp. 187–209, Garland Stpm Press, New York.Google Scholar
  219. Price, M. R., Hannant, D., Bowen, J. G., and Baldwin, R. W., 1980a, Suppressor cells in rats immunized against solubilized hepatoma specific antigens, Br. J. Cancer 42: 176.Google Scholar
  220. Price, M. R., Hannant, D., Embleton, M. J., and Baldwin, R. W., 1980b, Detection and isolation of tumour associated antigens; Icrew Workshop Report, Br. J. Cancer 41: 843.Google Scholar
  221. Reddy, A. L., and Fialkow, P. J., 1979, Multicellular origin of fibrosarcomas in mice induced by the chemical carcinogen 3-methylcholanthrene, J. Exp. Med. 150: 878.PubMedGoogle Scholar
  222. Rees, R. C., Price, M. R., Baldwin, R. W., and Shah, L. P., 1974, Inhibition of rat lymph node cell cytotoxicity by hepatoma-associated embryonic antigen, Nature (London) 252: 751.Google Scholar
  223. Rees, R. C., Price, M. R., Shah, L. P., and Baldwin, R. W., 1975a, Detection of hepatoma-associated embryonic antigen in tumour-bearer serum, Transplantation 19: 424.PubMedGoogle Scholar
  224. Rees, R. C., Shah, L. P., and Baldwin, R. W., 1975b, Inhibition of pulmonary tumour development in rats sensitised to rat embryonic tissue, Nature (London) 255: 329.Google Scholar
  225. Rees, R. C., Price, M. R., and Baldwin, R. W., 1979, Oncodevelopmental antigen expression in chemical carcinogenesis, Methods Cancer Res. 18: 99.Google Scholar
  226. Reiner, J., and Southam, C. M., 1967, Evidence of common antigenic properties in chemically induced sarcomas of mice, Cancer Res. 27: 1243.PubMedGoogle Scholar
  227. Reiner, J., and Southam, C. M., 1969, Further evidence of common antigenic properties in chemically induced sarcomas of mice, Cancer Res. 29: 1814.PubMedGoogle Scholar
  228. Reisfeld, R. A., and Kahan, B. D., 1970, Biological and chemical characterization of human histocompatibility antigens, Fed. Proc. Fed. Am. Soc. Exp. Biol. 29: 2034.Google Scholar
  229. Reisfeld, R. A., and Kahan, B. D., 1972, Markers of biological individuality, Sci. Am. 226 (6): 28.Google Scholar
  230. Révész, L., 1960, Detection of antigenic differences in isologous host-tumor systems by pretreatment with heavily irradiated tumor cells, Cancer Res. 20: 443.Google Scholar
  231. Roberts, J. J., 1980, Carcinogen-induced Dna damage and its repair, Br. Med. Bull. 36: 25.PubMedGoogle Scholar
  232. Robinson, N. C., and Tanford, C., 1975, The binding of deoxycholate, Triton X-100, sodium dodecyl sulfate, and phosphatidylcholine vesicles to cytochrome b5 Biochemistry 14: 369.PubMedGoogle Scholar
  233. Rogers, M. J., Law, L. W., and Appella, E., 1978, Separation of the tumor rejection antigen (Tsta) from the major viral structural proteins associated with the membrane of an R-MuLV-induced leukemia, in: Biological Markers of Neoplasia: Basic and Applied Aspects ( R. W. Ruddon, ed.), pp. 53–62, Elsevier, New York.Google Scholar
  234. Rosen, S. W., Weintraub, B. D., Vaitukaitis, B. D., Sussman, H. H., Hershman, J. M., and Muggia, F. M., 1975, Placental proteins and their sub units as tumor markers, Ann. Intern. Med. 82: 71.Google Scholar
  235. Ruppert, B., Wei, W., Medina, D., and Heppner, G. M., 1978, Effect of chemical carcinogen treatment on the immunogenicity of mouse mammary tumors arising from hyperplastic alveolar nodule outgrowth lines, J. Natl. Cancer Inst. 61: 1165.PubMedGoogle Scholar
  236. Sage, E., Spodheim-Maurizot, M., Rio, P., Leng, M., and Fuchs, R. P. P., 1979, Discrimination by antibodies between local defects in Dna induced by 2-aminofluorene derivatives, Febs Lett. 108: 66.PubMedGoogle Scholar
  237. Schinitsky, M. R., Hyman, L. R., Blazkovec, A. A., and Burkholder, P. M., 1973, Bacillus Calmette-Guérin vaccination and skin tumor promotion, Cancer Res. 33: 659.Google Scholar
  238. Schirrmacher, V., and Robinson, P., 1979, Differences between normal cells and tumor cells in their expression of certain H-2 determinants, in: Current Trends in Tumor Immunology ( S. Ferrone, S. Gorini, R. B. Herberman, and R. A. Reisfeld, eds.), pp. 335–346, Garland Stpm Press, New York.Google Scholar
  239. Sell, S., and Becker, F. F., 1978, Alpha-fetoprotein, J. Natl. Cancer Inst. 60: 19.PubMedGoogle Scholar
  240. Shah, L. P., Rees, R. C., and Baldwin, R. W., 1976, Tumour rejection in rats sensitized to embryonic tissue. I. Rejection of tumour cells implanted subcutaneously and detection of cytotoxic lymphoid cells, Br. J. Cancer 33: 577.PubMedCentralPubMedGoogle Scholar
  241. Shearer, G. M., and Schmitt-Verhulst, A. M., 1977, Major histocompatibility complex restricted cell-mediated immunity, Adv. Immunol. 25: 55.PubMedGoogle Scholar
  242. Shearer, G. M., Schmitt-Verhulst, A. M., and Rehn, T. G., 1977, Significance of the major histocompatibility complex as assessed by T-cell-mediated lympholysis involving syngeneic stimulating cells, Contemp. Top. Immunobiol. 7: 221.PubMedGoogle Scholar
  243. Sikora, K., Koch, G., Brenner, S., and Lennox, E., 1979, Partial purification of tumour-specific transplantation antigens from methylcholanthrene-induced murine sarcomas by immobilized lectins, Br. J. Cancer 40: 831.PubMedCentralPubMedGoogle Scholar
  244. Singer, R. M., 1979, Fetal isoenzyme modulation in human tumor xenografts, Methods Cancer Res. 18: 169.Google Scholar
  245. Sjögren, H. O., and Steele, G., 1975a, Colon carcinoma antigens in the rat, Ann. N.Y. Acad. Sci. 259: 404.PubMedGoogle Scholar
  246. Sjögren, H. O., and Steele, G., 1975b, The immunology of large bowel carcinoma in a rat model, Cancer 36: 2469.PubMedGoogle Scholar
  247. Sondel, P. M., and Bach, F. H., 1980, The alienation of tumor immunity: Alien driven diversity and alien selected escape, Transplant. Proc. 7: 211.Google Scholar
  248. Stavrou, D., Anzil, A. P., and Elling, H., 1978, Tumor specific fluorescent and complement-dependent cytotoxic antibodies in the serum of rats with chemically induced brain gliomas, Acta Neuropathol. (Berlin) 43: 111.Google Scholar
  249. Steele, G., and Sjögren, H. O., 1974, Embryonic antigens associated with chemically induced colon carcinomas in rats, Int. J. Cancer 14: 435.PubMedGoogle Scholar
  250. Steele, G., and Sjörgren, H. O., 1977, Cell surface antigens in a rat colon cancer model: Correlation with inhibition of tumor growth, Surgery 82: 164.PubMedGoogle Scholar
  251. Steele, G., Sjörgren, H. O., and Price, M. R., 1975a, Tumor-associated and embryonic antigens in soluble fractions of a chemically-induced rat colon carcinoma, Int. J. Cancer 16: 33.PubMedGoogle Scholar
  252. Steele, G., Sjörgren, H. O., Rosengren, J. E., LindstrÖM, C., Larson, A., and Leandoer, L., 1975b, Sequential studies of serum blocking activity in rats bearing chemically induced primary bowel tumors, J. Natl. Cancer Inst. 54: 959.PubMedGoogle Scholar
  253. Stutman, O., 1975, Immunodepression and malignancy, Adv. Cancer Res. 22: 261.PubMedGoogle Scholar
  254. Sugarbaker, E. V., and Cohen, A. M., 1972, Altered antigenicity in spontaneous pulmonary metastases from an antigenic murine sarcoma, Surgery 72: 155.PubMedGoogle Scholar
  255. Suter, L., Bloom, B. R., Wadsworth, E. M., and Oettgen, H. F., 1972, Use of the macrophage migration inhibition test to monitor fractionation of soluble antigens of chemically induced sarcomas of inbred guinea pigs, J. Immunol. 109: 766.PubMedGoogle Scholar
  256. Takasugi, M., and Klein, E., 1970, A microassay for cell-mediated immunity, Transplantation 9: 219.PubMedGoogle Scholar
  257. Takeda, K., 1969, Immunology of Cancer, Hokkaido University, Sapporo, Japan.Google Scholar
  258. Tao, T.-W., and Burger, M. M., 1977, Non-metastasising variants selected from metastasising melanoma cells, Nature (London) 270: 437.Google Scholar
  259. Taranger, L. A., Chapman, W. H., Hellström, I., and Hellström, K. E., 1972a, Immunological studies on urinary bladder tumors of rats and mice, Science 176: 1337.PubMedGoogle Scholar
  260. Taranger, L. A., Hellström, I., Chapman, W. H., and HellstrÖM, K. E., 1972b, In vitro demonstration of common tumor antigens in mouse and rat bladder carcinomas, Proc. Am. Assoc. Cancer Res. 13: 56.Google Scholar
  261. Thomson, D. M. P., Gold, P., Freedman, S. O., and Shuster, J., 1976, The isolation and characterization of tumor-specific antigens of rodent and human tumors, Cancer Res. 36: 3518.PubMedGoogle Scholar
  262. Thomson, D. M. P., Tataryn, D. N., O’Connor, R., Rauch, J., Friedlander, P., Gold, P., and Shuster, J., 1979, Evidence for the expression of human tumorspecific antigens associated with ß-2 microglobulin in human cancer and in some colon adenomas and benign breast lesions, Cancer Res. 39: 604.PubMedGoogle Scholar
  263. Ting, C. C., and Grant, J. P., 1976, Humoral antibody response and tumor transplantation resistance elicited by fetal tissues in mice, J. Natl. Cancer Inst. 56: 401.PubMedGoogle Scholar
  264. Ting, C. C., and Herberman, R. B., 1971, Inverse relationship of polyoma tumorspecific cell surface antigen to H-2 histocompatibility antigens, Nature New Biol. 232: 118.PubMedGoogle Scholar
  265. Tracey, R. S., Wepsic, H. T., Alaimo, J., and Morris, H. P., 1978, Growth of transplanted rat tumors following administration of cell-free tumor antigens, Cancer Res. 38: 1208.PubMedGoogle Scholar
  266. Tuffrey, M. A., and Batchelor, J. R., 1964, Tumour specific immunity against murine epitheliomas induced with 9,10-dimethyl-1,2-benzanthracene, Nature (London) 204: 349.Google Scholar
  267. Wahl, D. V., Chapman, W. H., Hellström, I., and Hellström, K. E., 1974, Transplantation immunity to individually unique antigens of chemically induced bladder tumors in mice, Int. J. Cancer 14: 114.PubMedGoogle Scholar
  268. Weinhouse, S., 1972, Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G. H. A. Clowes Memorial Lecture, Cancer Res. 32: 2007.Google Scholar
  269. Wepsic, H. T., Zbar, B., Rapp, H. J., and Borsos, T., 1970, Systemic transfer of tumor immunity: Delayed hypersensitivity and suppression of tumor growth, J. Natl. Cancer Inst. 44: 955.PubMedGoogle Scholar
  270. Wepsic, H. T., Nickel, R., and Alaimo, J., 1976, Characterization of growth properties and demonstration of the tumor-specific transplantation antigens of Morris hepatomas, Cancer Res. 35: 246.Google Scholar
  271. Whitmore, C. E., Salerno, R. A., Rabstein, L. S., Huebner, R. J., and Turner, H. C., 1971, Rna tumor-virus antigen expression in chemically induced tumors. Virus-genome-specified common antigens detected by complement fixation in mouse tumors induced by 3-methylcholanthrene, J. Natl. Cancer Inst. 47: 1255.Google Scholar
  272. Williams, A. F., 1977, Differentiation antigens of the lymphocyte cell surface, Contemp. Top. Mol. Immunol. 6: 83.PubMedGoogle Scholar
  273. Williams, G. M., 1979, Liver cell culture systems for the study of hepatocarcinogenesis, in: Advances in Medical Oncology, Research and Education, Vol. 1 (G. P. Margison, ed.), pp. 273–293, Pergamon Press, Oxford.Google Scholar
  274. Williams, G. M., Elliott, J. M., and Weisburger, J. H., 1973, Carcinoma after malignant conversion in vitro of epithelial-like cells from rat liver following exposure to chemical carcinogens, Cancer Res. 33: 606.PubMedGoogle Scholar
  275. Woodruff, M., and Speedy, G., 1978, Inhibition of chemical carcinogenesis by Corynebacterium parvum, Proc. R. Soc. London Ser. B 201: 209.Google Scholar
  276. Wrathmell, A. B., Gauci, C. L., and Alexander, P., 1976, Cross-reactivity of an alloantigen present on normal cells with the tumour-specific transplantation type antigen of the acute myeloid leukaemia (Sal) of rats, Br. J. Cancer 33: 187.PubMedCentralPubMedGoogle Scholar
  277. Yokota, T., Sizaret, P., and Martel, N., 1978, Tumor-specific antigens on rat liver cells transformed in vitro by chemical carcinogens, J. Natl. Cancer Inst. 60: 125.PubMedGoogle Scholar
  278. Zbar, B., Wepsic, H. T., Rapp, H. J., Borsos, T., Kronman, B. S., and Churchill, W. H., 1969, Antigenic specificity of hepatomas induced in strain-2 guinea pigs by diethlynitrosamine, J. Natl. Cancer Inst. 43: 833.PubMedGoogle Scholar
  279. Zbar, B., Wepsic, H. T., Rapp, H. J., Stewart, L. C., and Borsos, T., 1970, Two-step mechanism of tumor graft rejection in syngeneic guinea pigs. II. Initiation of reaction by a cell fraction containing lymphocytes and neutrophils, J. Natl. Cancer Inst. 44: 701.PubMedGoogle Scholar
  280. Zbar, B., Bernstein, I. D., and Rapp, H. J., 1971, Suppression of tumor growth at the site of infection with living bacillus Calmette Guérin, J. Natl. Cancer Inst. 46: 831.Google Scholar
  281. Zbar, B., Bernstein, I. D., Bartlett, G. L., Hanna, G., and Rapp, H. J., 1972a, Immunotherapy of cancer: Regression of intradermal tumors and prevention of growth of lymph node metastases after intralesional injection of living Mycobacterium bovis, J. Natl. Cancer Inst. 49: 119.Google Scholar
  282. Zbar, B., Rapp, H. J., and Rim, E. E., 1972 b, Tumor suppression by cell walls of Mycobacterium bovis attached to oil droplets, J. Natl. Cancer Inst. 48: 831.Google Scholar
  283. Zinkernagel, R. M., and Doherty, P. C., 1977, Major transplantation antigens, viruses, and specificity of surveillance T cells, Contemp. Top. Immunobiol. 7: 179.PubMedGoogle Scholar
  284. Zöller, M., Price, M. R., and Baldwin, R. W., 1975, Cell-mediated cytotoxicity to chemically induced rat tumours, Int. J. Cancer 16: 593.PubMedGoogle Scholar
  285. Zoller, M., Price, M. R., and Baldwin, R. W., 1976, Inhibition of cell-mediated cytotoxicity to chemically induced rat tumours by soluble tumour and embryo cell extracts, Int. J. Cancer 17: 129.PubMedGoogle Scholar
  286. Zoller, M., Price, M. R., and Baldwin, R. W., 1977, Evaluation of 51Cr release for detecting cell-mediated cytotoxic responses to solid chemically-induced rat tumours, Br. J. Cancer 35: 834.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Robert W. Baldwin
    • 1
  • Michael R. Price
    • 1
  1. 1.Cancer Research Campaign LaboratoriesUniversity of NottinghamNottinghamEngland

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