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Neoantigen Expression in Chemical Carcinogenesis

  • Robert W. Baldwin
  • Michael R. Price
Chapter
Part of the Cancer, A Comprehensive Treatise book series (C)

Abstract

Neoplastic transformation induced by chemical carcinogens results in the expression in transformed cells of antigens that are not present in their normal cell counterpart, at least in the adult host. In early studies with chemically induced tumors (Foley, 1953; Baldwin, 1955; Prehn and Main, 1957), neoantigens were defined by their capacity to elicit immunity to transplanted tumor and were termed “tumor-specific transplantation antigens.” It is now evident that immune responses are elicited against these antigens in the autochthonous host, and considerable effort has been directed to resolve their role as a limiting (or enhancing) component of chemical carcinogenesis. It is appropriate to refer to these classical neoantigens, which are characterized by an immunological specificity that is unique to individual tumors, as “tumor-associated rejection antigens” (the term “tumor-specific” has been avoided here since recent experiments have raised the possibility that these antigens may be induced in nontransformed cells and so cannot be viewed as specific markers of malignancy).

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Robert W. Baldwin
    • 1
  • Michael R. Price
    • 1
  1. 1.Cancer Research Campaign LaboratoriesUniversity of NottinghamNottinghamEngland

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