Sequential Events in Chemical Carcinogenesis

  • Emmanuel Farber
Part of the Cancer, A Comprehensive Treatise book series (C)


It has become increasingly evident that the vast majority of if not all cancers develop slowly as a multistep process in which discrete focal new cell populations appear sequentially as possible precursor lesions for the next step (Foulds, 1969, 1975; Farber, 1973a; Farber and Cameron, 1980; Farber and Sporn, 1976; Medline and Farber, 1980). The multistep patterns appear to occur in most known instances of cancer induced by chemicals and radiations and by some viruses (Foulds, 1975; Farber and Cameron, 1980; Peto, 1977). The field has been reviewed by Foulds (1969, 1975) in extenso and more recently by Farber and Cameron (1980) and there is no need for an additional comprehensive review at this time. However, it does appear to be appropriate to consider analytically and critically some of the component processes in chemical carcinogenesis and to discuss some emerging general principles that seem to be pertinent to the further study of mechanisms of cancer development with chemicals.


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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Emmanuel Farber
    • 1
  1. 1.Departments of Pathology and BiochemistryUniversity of TorontoTorontoCanada

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