Sequential Aspects of Chemical Carcinogenesis: Skin

  • Isaac Berenblum
Part of the Cancer, A Comprehensive Treatise book series (C)


The first indication that experimental carcinogenesis could be augmented by the addition of noncarcinogenic stimuli resulted from scarification of mouse skin combined with, or following, tar painting (Deelman, 1924; Deelman and van Erp, 1926), and later, from combined applications of carcinogenic hydrocarbons with (noncarcinogenic) creosote oil (Sall et al., 1940). But the establishment of sequential stages in carcinogenesis arose by the convergence of two subsequent lines of inquiry.


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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Isaac Berenblum
    • 1
  1. 1.The Weizmann Institute of ScienceRehovotIsrael

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