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Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids

  • S. Rajalakshmi
  • Prema M. Rao
  • D. S. R. Sarma
Chapter
Part of the Cancer, A Comprehensive Treatise book series (C)

Abstract

Some of the major conceptual advances in chemical carcinogenesis made during the past several years have been (1) the discovery of the enzymatic activation of procarcinogens to reactive ultimate carcinogens, (2) the characterization of interactions of the active metabolites of many carcinogens with a variety of tissue nucleophiles including DNA, RNA, and protein, and (3)the development of model systems for a sequential analysis of the initiation phase of carcinogenesis. This chapter primarily focuses on the interactions of chemical carcinogens and their activated metabolites with nucleic acids, both DNA and RNA.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • S. Rajalakshmi
    • 1
  • Prema M. Rao
    • 1
  • D. S. R. Sarma
    • 1
  1. 1.Department of PathologyUniversity of TorontoTorontoCanada

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