Abstract
Some of the major conceptual advances in chemical carcinogenesis made during the past several years have been (1) the discovery of the enzymatic activation of procarcinogens to reactive ultimate carcinogens, (2) the characterization of interactions of the active metabolites of many carcinogens with a variety of tissue nucleophiles including DNA, RNA, and protein, and (3)the development of model systems for a sequential analysis of the initiation phase of carcinogenesis. This chapter primarily focuses on the interactions of chemical carcinogens and their activated metabolites with nucleic acids, both DNA and RNA.
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References
Abanobi, S. E., Columbano, A., Mulivor, R. A., Rajalakshmi, S., And Sarma, D. S. R., 1980. In vivo replication of hepatic deoxyribonucleic acid of rats treated with dimethylnitrosamine: Presence of dimethylnitrosamine induced O 6-methylguanine, N-7-methylguanine and N-3-methyladenine in the replicated hybrid deoxyribonucleic acid, Biochemistry 19: 1382.
Abbott, P. J., And Saffhill, R., 1977, DNA synthesis with methylated poly(dA-dT) template: Possible role of O 4-methylthymine as a promutagenic base, Nucleic Acids Res. 4: 761.
Abbott, P. J., And Saffhill, R., 1979, DNA synthesis with methylated poly(dC-dG) templates: Evidence for competitive nature to miscoding by O 6-methylguanine, Biochim. Biophys. Acta 562: 51.
Agarwal, M. K., And Weinstein, I. B., 1970, Modifications of ribonucleic acid by chemical carcinogens. II. In vivo reaction of N-2-acetylaminofluorene with rat liver ribonucleic acid, Biochemistry 9: 503.
Alexander, P., 1952, Interference with the formation of a nucleoprotein complex by radiomimetic compounds, Nature (London) 169: 226.
Alexander, P., 1969, Comparison of the mode of action by which some alkylating agents and ionizing radiations kill mammalian cells, Ann. N.Y. Acad. Sci. 163: 652.
Alexandrov, K., Vendrely, C., and Vendrely, R., 1970, A comparative study of the action of carcinogenic substances on the RNA synthesis in mouse skin, Cancer Res. 30: 1192.
Altamirano-Dimas, M., Sklar, R., And Strauss, B., 1979, Selectivity of the excision of alkylation products in a xeroderma-pigmentosum derived lymphoblastoid line, Mutat. Res. 60: 197.
Andoh, T., Kato, K., Takaoka, T., And Katsuta, H., 1971, Carcinogenesis in tissue culture. XIII. Binding of 4-nitroquinoline-1-oxide-3H to nucleic acids and proteins of L.P3 and JTC 25-P3 cells, Int. J. Cancer 7: 455.
Araki, M., Kawazoe, Y., And Nagata, C., 1969, Chemical carcinogens. IX. Homolytic degradation of O,O’-diacetyl-4-hydroxyaminoquinoline-1-oxide (1-acetoxy-4-acetyloxyimino-1,4-dihydroquinoline), Chem. Pharm. Bull. 17: 1344.
Arcos, J. C., And Argus, M. F., 1968, Molecular geometry and carcinogenic activity of aromatic compounds: New perspectives, Adv. Cancer Res. 11: 305.
Arcos, J. C., Venkatesen, N., And Argus, M. F., 1971 Modification of the flow dichroism spectrum of rat liver nuclear Dna by in vivo alkylation with hepatocarcinogenic dialkylnitrosamines, Gann 62: 523.
Arnold, E. A., And Young, K. E., 1974, Heterogeneity of chromatin: Fractionation of sonicated rat liver chromatin by partial precipitation with Mgt’, Arch. Biochem. Biophys. 164: 73.
Arnott, S., Chandrasekaran, R., Birdsall, D. L., Leslie, A. G. W., And Retliff, R. L., 1980, Left handed Dna helices, Nature (London) 283: 743.
Axel, R., 1975, Cleavage of Dna in nuclei and chromatin with staphylococcal nuclease, Biochemistry 14: 2921.
Axel, R., Weinstein, I. B., And Farber, E., 1967, Patterns of transfer Rna in normal rat liver during hepatic carcinogenesis, Proc. Natl. Acad. Sci. Usa 58: 1255.
Axel, R., Cedar, H., And Felsenfeld, G., 1975, The structure of the globin genes in chromatin, Biochemistry 14: 2489.
Backer, J. M., And Weinstein, I. B., 1980, Modification of mitochondrial Dna by a dihydrodiolepoxide derivative of benzo(a)pyrene, Proc. Am. Assoc. Cancer Res. 21: 93.
Bannon, P., And Verly, W., 1972, Alkylation of phosphates and stability of phosphate triesters in Dna, Fur. J. Biochem. 31: 103.
Barbin, A., Bresil, H., Crosy, A., Jacquignon, P., Malaveille, C., Montesano, R., And Bartsch, H., 1975, Liver microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride, Biochem. Biophys. Res. Commun. 67: 596.
Bartsch, H., And Montesano, R., 1975, Mutagenic and carcinogenic effects of vinyl chloride, Mutat. Res. 32: 93.
Bartsch, H., Miller, J. A., And Miller, E. C., 1972, Activation of carcinogenic aromatic hydroxylamines by enzymatic O-acetylation, Proc. Am. Assoc. Cancer Res. 13: 12.
Bartsch, H., Montesano, R., And Malaveille, C., 1975, Human, rat and mouse liver-mediated mutagenicity of the vinyl chloride in S. typhimurium strains, Int. J. Cancer 15: 429.
Beach, D. J., And Sunderman, F. W., JR., 1970, Nickel carbonyl inhibition of Rna synthesis by a chromatin—Rna polymerase complex from hepatic nuclei, Cancer Res. 30: 48.
Weland, F. A., 1978, Computer generated graphic models of the N2-substituted deoxyguanosine adducts of 2-acetylaminofluorene and benzo(a)pyrene and the 06-substituted deoxyguanosine adduct of 1-naphthylamine in the Dna double helix, Chem. Biol. Interact. 22: 329.
Benfey, O. T., 1970, Introduction to Organic Reaction Mechanisms, McGraw-Hill, New York.
Berenblum, I., And Trainin, N., 1960, Possible two-stage mechanism in experimental leukemogenesis, Science 132: 40.
Bergmann, F., 1942, On the mechanism of tumor production by chemical agents, Cancer Res. 2: 660.
Black, H. S., And Jirgensons, B., 1967, Interactions of aflatoxin with histones and Dna, Plant Physiol. 42: 731.
Blackburn, G. M., Fenwick, R. G., And Thompson, M. W., 1972, Structure of the thymine-3,4benzopyrene photoproduct, Tetrahedron Lett. 7: 589.
Bloom, K. S., And Anderson, J. N., 1978, Fractionation of hen oviduct chromatin into transcriptionally active and inactive regions after selective micrococcal nuclease digestion, Cell 15:141. Bodell, W. J., 1977, Nonuniform distribution of Dna repair in chromatin after treatment with methylmethanesulfonate, Nucleic Acids Res. 4: 2619.
Bodell, W. J., And Banerjee, M. R., 1976, Reduced Dna repair in mouse satellite Dna after treatment with methylmethanesulfonate and N-methyl-N-nitrosourea, Nucleic Acids Res. 3: 1689.
Bodell, W. J., And Banerjee, M. R., 1979, The influence of chromatin structure on the distribution of Dna repair synthesis studied by nuclease digestion, Nucleic Acids Res. 6: 359.
Bodell, W. J., Singer, B., Thomas, G. H., And Cleaver, J. A., 1979, Evidence for removal at different rates of 0-ethyl pyrimidines and ethyl phosphotriesters in two human fibroblast cell lines, Nucleic Acids Res. 6: 2819.
Bonner, J., Gottesfeld, J., Gerrard, W., Belling, R., And Uphouse, L., 1975, Isolation of template active and inactive regions of chromatin, Methods Enzymol. 40E: 97.
Borek, C., And Sachs, L., 1967, The number of cell generations required to fix the transformed state in X-ray-induced transformation, Proc. Natl. Acad. Sci. Usa 57: 1522.
Boutwell, R. K., Colburn, N. H., And Muckerman, C. C., 1969, In vivo reactions of ß-propiolactone, Ann. N. Y. Acad. Sci. 163: 751.
Bowden, G. T., And Boutwell, R. K., 1973, The binding of 7,12-dimethylbenz(a)anthracene (Dmba) to replicating and non-replicating Dna in vivo, Proc. Am. Assoc. Cancer Res. 14: 28.
Oyland, E., 1969, The biochemistry of aromatic hydrocarbons, amines and urethane, in Physicochemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 ( E. D. Bergmann and B. Pullman, eds), p. 25, The Israel Academy of Science and Humanities, Jerusalem.
Boyland, E., And Sims, P., 1965, Metabolism of polycyclic compounds. The metabolism of 7,12dimethylbenz(a) anthracene by rat liver homogenates, Biochem. J. 95: 780.
Boyland, E., And Williams, K., 1969, Reaction of urethane with nucleic acids in vivo, Biochem. J. 111: 121.
Brash, D. E., And Hart, R. W., 1978, Dna damage and repair in vivo, J. Environ. Pathol. Toxicol. 2: 79.
Brawerman, G., 1974, Eukaryotic messenger Rna, Annu. Rev. Biochem. 43: 621.
Brent, T. P., 1976, Purification and characterization of human endonucleases specific for damaged Dna, Biochim. Biophys. Acta 454: 172.
Brent, T. P., 1979, Partial purification and characterization of a human 3-methyladenine-Dna glycosylase, Biochemistry 18: 911.
Bridges, B. A., 1976, Short term screening tests for carcinogens, Nature (London) 261: 195.
Brinker, J. M., Madore, A. P., And Bello, L. J., 1973, Stabilization of heterogeneous nuclear Rna by intercalating drugs, Biochem. Biophys. Res. Commun. 52: 928.
Britten, R. J., And Davidson, E. H., 1969, Gene regulation for higher cells: A theory—New facts regarding the organization of genome provide clues to the nature of gene regulation, Science 165: 349.
Britten, R. J., And Kohne, D. E., 1968, Repeated sequences in Dna. Hundreds and thousands of copies of Dna sequences have been incorporated into the genome of higher organisms, Science 161: 529.
Brookes, P., 1966, Quantitative aspects of the reaction of some carcinogens with nucleic acids and the possible significance of such reactions in the process of carcinogenesis, Cancer Res. 26: 1994.
Brookes, P., And Lawley, P. D., 1960, The reaction of mustard gas with nucleic acids in vitro and in vivo, Biochem. J. 77: 478.
Brookes, P., And Lawley, P. D., 1961, The reaction of mono- and di-functional alkylating agents with nucleic acids, Biochem. J. 80: 496.
Brookes, P., And Lawley, P. D., 1964, Evidence for the binding of polynuclear aromatic hydrocarbons to the nucleic acids of mouse skin: Relation between carcinogenic power of hydrocarbons and their binding to deoxyribonucleic acid, Nature (London) 202: 781.
Brown, G. B., Teller, M. N., Smullyan, I., Birdsall, N. J. M., Lee, T.-C., Parham, J. C., And Stohrer, G., 1973, Correlations between oncogenic and chemical properties of several derivatives of 3-hydroxyxanthine and 3-hydroxyguanine, Cancer Res. 33: 1113.
Buckley, J. D., O’Connor, P. J., And Craig, A. W., 1979, Pretreatment with acetylaminofluorene enhances the repair of 06-methylguanine in Dna, Nature (London) 281: 403.
Buecheler, J., And Kleihues, P., 1977, Excision of 06-methylguanine from Dna of various mouse tissues following a single injection of N-methyl-N-nitrosourea, Chem. Biol. Interact. 16: 325.
Buhl, S. N., Setlow, R. B., And Regan, J. D., 1974, Recovery of the ability to synthesize Dna in segments of normal size at long times after UV irradiation of human cells, Biophys. J. 13: 1265.
Butzow, J. J., And Eichhorn, G. L., 1965, IV. Degradation of polyribonucleotides by zinc and other divalent metal ions, Biopolymers 3: 95.
Cathcart, R., And Goldthwait, D. A., 1981, Enzymatic excision of 3-methyladenine and 7methylguanine by a rat liver nuclear fraction, Biochemistry 20: 273.
Cayama, E., Tsuda, H., Sarma, D. S. R., And Farber, E., 1978, Initiation of chemical carcinogenesis requires cell proliferation, Nature (London) 275: 60.
Cerutti, P. A., Sessions, F., Hariharan, P. V., And Lusby, A., 1978, Repair of Dna damage induced by benzo(a)pyrene diol epoxides I and II in human alveolar tumor cells, Cancer Res. 38: 2118.
Chan, J. Y. H., And Becker, F. F., 1979, Decreased fidelity of Dna polymerase activity during N-2-fluorenylacetamide hepatocarcinogenesis, Proc. Natl. Acad. Sci. Usa 76: 814.
Chetsanga, C., And Lindahl, T., 1979, Release of 7-methylguanine residues whose imidazole rings have been opened from damaged Dna by a Dna glycosylase from Escherichia coli, Nucleic Acids Res. 6: 3673.
Clark, R. J., And Felsenfeld, G., 1971, Structure of chromatin, Nature (London) 229: 101.
Clayson, D. B., And Garner, R. C., 1976, Carcinogenic aromatic amines and related compounds, in Chemical Carcinogens (C. E. Searle, ed.), p. 366, Acs Monograph 173, Washington, D.C.
Cleaver, J. E., 1968, Defective repair replication of Dna in xeroderma pigmentosum, Nature (London) 218: 652.
Cleaver, J. E., 1969, Xeroderma pigmentosum: A human disease in which an initial stage of Dna repair is defective, Proc. Natl. Acad. Sci. Usa 63: 428.
Cleaver, J. E., 1977, Nucleosome structure controls rates of excision repair in Dna of human cells, Nature (London) 270: 451.
Cleaver, J. E., 1978, Dna repair and its coupling to Dna replication in eukaryotic cells, Biochim. Biophys. Acta 516: 489.
Clifford, J. I. And Rees, K. R., 1967, The action of aflotoxin B1 on the rat liver, Biochem. J. 102: 65.
Cohen, S. M., Alter, A., And Bryan, G. T., 1973, Distribution of radioactivity and metabolism of formic acid 2-[4-(5-nitro-2-furyl)-2–14C-2-thiazolyl]hydrazide following oral administration to rats and mice, Cancer Res. 33: 2802.
Cohn, W. E., And Volkin, E., (eds.), 1976, m-Rna: The relation of structure and function, Prog. Nucleic Acid Res. Mol. Biol. 19.
Colburn, N. H., And Boutwell, R. K., 1968, The in vivo binding of propiolactone to mouse skin Dna, Rna and protein, Cancer Res. 28: 642.
Columbano, A., Rao, P. M., Rajalakshmi, S., And Sarma, D. S. R., 1980, Presence of dimethylnitrosamine (Dmn) induced methylated products in the parental strand of the in vivo replicated, S1 nuclease resistant, hybrid liver Dna, Proc. Am. Assoc. Cancer Res. 21: 86.
Cookson, M. J., Sims, P., And Grover, P. L., 1971, Mutagenicity of epoxides of polycyclic hydrocarbons correlates with carcinogenicity of parent hydrocarbons, Nature (London) 234: 186.
Cooper, H. K., Margison, G. P., O’Connor, P. J., And Itzhaki, R. F., 1975, Heterogenous distribution of Dna alkylation products in rat-liver chromatin after in vivo administration of N,N-di[14C]methylnitrosamine, Chem. Biol. Interact. 11: 483.
Cox, R., 1979, Differences in the removal of N-methyl-N-nitrosourea methylated products in DNase-I-sensitive and resistant regions of rat brain Dna, Cancer Res. 39: 2675.
Cox, R., And Farber, E., 1972, Ethylation of Dna versus cancer induction with ethionine, Proc. Am. Assoc. Cancer Res. 13: 97.
Cox, R., And Irving, C. C., 1977, Selective accumulation of 06-methylguanine in Dna of rat bladder epithelium after intravesical administration of N-methyl-N-nitrosourea, Cancer Lett. 3: 265.
Cox, R., And Irving, C. C., 1979, 06-Methylguanine accumulates in Dna of mammary glands after administration of N-methyl-N-nitrosourea to rats, Cancer Lett. 6: 273.
Cox, R., Damjanov, I., Abanobi, S., And Sarma, D. S. R., 1973, A method for measuring Dna damage and repair in the liver in vivo, Cancer Res. 33: 2114.
Coyle, M. B., And Strauss, B. S., 1969–1970, Characteristics of Dna synthesized by methylmethanesulfonate treated HEp-2 cells, Chem. Biol. Interact. 1: 89.
Craddock, V. M., 1969, Methylation of t-Rna and ribosomal Rna in rat liver in the intact animal and the effect of carcinogens, Biochim. Biophys. Acta 195: 351.
Craddock, V. M., 1973, Induction of liver tumours in rats by a single treatment with nitroso compounds given after partial hepatectomy, Nature (London) 245: 386.
Craddock, V. M., Villa-Trevino, S., And Magee, P. N., 1968, Occurrence of 7-methylguanine in nucleic acids of rat liver, Biochem. J. 107: 179.
D’Ambroslo, S. M., And Setlow, R. B., 1976, Enhancement of post-replicative repair in Chinese hamster cells, Proc. Natl. Acad. Sci. Usa 73: 2396.
Damjanov, I., Cox, R., Sarma, D. S. R., And Farber, E., 1973, Patterns of damage and repair of liver Dna induced by carcinogenic methylating agents in vivo, Cancer Res. 33: 2122.
D’Andrea, A. D., And Haseltine, W. A., 1978, Modification of Dna by aflatoxin B1 creates alkali-labile lesions in Dna at positions of guanine and adenine, Proc. Natl. Acad. Sci. Usa 75: 4120.
Darnell, J. E., 1968, Ribonucleic acids from animal cells, Bacteriol. Rev. 32: 262.
Debaun, J. R., Smith, J. Y. R., Miller, E. C., And Miller, J. A., 1970, Reactivity in vivo of the carcinogen N-hydroxy-2-acetylaminofluorene: Increase by sulfate ion, Science 167: 184.
Den Engelse, L., And Phillipus, E. J., 1977, In vivo repair of rat liver Dna damaged by dimethylnitrosamine or diethylnitrosamine, Chem. Biol. Interact. 19: 111.
Deutsch, W. A., And Linn, S., 1979, Dna binding activity from cultured human fibroblasts that is specific for partially depurinated Dna and that inserts purines into apurinic sites, Proc. Natl. Acad. Sci. Usa 76: 141.
Dickens, F., And Jones, H. E. H., 1963, Further studies on the carcinogenic and growth-inhibitory activity of lactones and related substances, Br. J. Cancer 17: 100.
Dijkstra, J., And Weide, S. S., 1972, Changes in chromatin caused by aminoazo compounds, Exp. Cell Res. 72: 345.
Dingman, C. W., And Sporn, M. B., 1967, The binding of metabolites of aminoazo-dyes to rat liver Dna in vivo, Cancer Res. 27: 938.
Dipaolo, J., 1960, Experimental evaluation of actinomycin D, Ann. N.Y. Acad. Sci. 89: 408.
Dipple, A., 1972, Model studies for azo-dye carcinogenesis, J. Chem. Soc. Perkin Trans. 1: 447.
Dipple, A., And Slade, T. A., 1970, Structure and activity in chemical carcinogenesis: Reactivity and carcinogenicity of 7-bromomethylbenz(a)anthracene and 7-bromomethyl-12-methylbenz(a)-anthracene, Eur. J. Cancer 6: 417.
Dipple, A., Brookes, P., Mackintosh, D. S., And Rayman, M. P., 1971, Reaction of 7-bromomethylbenz(a)anthracene with nucleic acids, polynucleotides and nucleosides, Biochemistry 10: 4323.
Druckrey, H., 1970, Production of colonic carcinomas by 1,2-dialkylhydrazines and azoxyalkanes, in Carcinoma of the Colon and Antecedent Epithelium (W. J. Burdette, ed.), p. 267, Thomas, Springfield, Ill.
Druckrey, H., 1972, Organospecific carcinogenesis in the digestive tract, in Proceedings of the Second International Symposium of The Princess Takamatsu Cancer Research Fund ( W. Nakahara, S. Takayama, T. Sugimura, and S. Odashima, eds.), p. 73, University Park Press, Baltimore.
Druckrey, H., Preussmann, R., Matzkus, F., And Ivankonie, S., 1967, Selektive Erzeugung Von Darmkrebs bei Ratten durch 1,2-dimethylhydrazin, Naturwissenschaften 54: 285.
Dube, S. K., Marcker, K. A., Clark, B. F. C., And Cory, S., 1968, Nucleotide sequence of N-formyl-methionyl transfer Rna, Nature (London) 218: 232.
Duncan, M., Brookes, P., And Dipple, A., 1969, Metabolism and binding to cellular macromolecules of a series of hydrocarbons by mouse embryo cells in culture, Int. J. Cancer 4: 813.
Dunn, D. B., 1963, The isolation of 1-methyladenylic acid and 7-methylguanylic acid from ribonucleic acid, Biochem. J. 86: 14 P.
Edwards, G. S., Wogan, G. N., Sporn, M. B., And Pong, R. S., 1971, Structure—activity relationships in Dna binding and nuclear effects of aflatoxin and analogs, Cancer Res. 31: 1943.
Eichhorn, G. L., Clark, P., And Becker, E. D., 1966, Interactions of metal ions with polynucleotides and related compounds. Vii. The binding of copper (II) to nucleosides, nucleotides and deoxyribonucleic acids, Biochemistry 5: 245.
Elkind, M. M., And Redpath, J. L., 1977, Molecular and cellular biology of radiation lethality, in Cancer: A Comprehensive Treatise, Vol. 6 ( F. F. Becker, ed.), p. 51, Plenum Press, New York.
Elmore, D. J., Gulland, J. M., Jordan, D. O., And Taylor, H. F. W., 1948, The reaction of nucleic acids with mustard gas, Biochem. J. 42: 308.
Enomoto, M., Sato, K., Miller, E. C., And Miller, J. A., 1968, Reactivity of the diacetyl derivative of the carcinogen 4-hydroxyaminoquinoline-1-oxide with Dna, Rna and other nucleophiles, Life Sci. 7: 1025.
Epstein, S. M., Benedetti, E. L., Shinozuka, H., Bartus, B., And Farber, E., 1969–1970, Altered and distorted Dna from a premalignant liver lesion induced by 2-fluorenylacetamide, Chem. Biol. Interact. 1: 113.
ErtÜRK, E., Morris, J. E., Cohen, S. M., Von Esch, A. M., Crovetti, A. J., Price, J. M., And Bryan, G. T., 1971, Comparative carcinogenicity of formic acid 2-[4-(5-nitro-2-furyl)-2thiazolyl]hydrazide and related chemicals in the rat, J. Natl. Cancer Inst. 47: 437.
Essigmann, J. M., Croy, R. G., Nazdan, A. M., Busby, W. F., JR., Reinhold, V. N., Buchi, G., And Wogan, G. N., 1977, Structural identification of the major Dna adduct formed by aflatoxin B1 in vitro, Proc. Natl. Acad. Sci. Usa 74: 1870.
Farber, E., 1963, Ethionine carcinogenesis, Adv. Cancer Res. 7: 383.
Farber, E., 1967, Ethionine fatty liver, Adv. Lipid Res. 5: 119.
Farber, E., 1968, Biochemistry of carcinogenesis, Cancer Res. 28: 1859.
Farber, E., And Magee, P. N., 1960, The probable alkylation of liver ribonucleic acid by the hepatic carcinogens dimethylnitrosamine and ethionine, Biochem. J 76: 58 P.
Farber, E., Shull, K. H., Villa-Trevino, S., Lombardi, B., And Thomas, M., 1964, Biochemical pathology of acute hepatic adenosinetriphosphate deficiency, Nature (London) 203: 34.
Farber, E., Mcconomy, J., Franzen, B., Marroquin, F., Stewart, G. A., And Magee, P. N., 1967a, Interaction between ethionine and rat liver ribonucleic acid and protein in vivo, Cancer Res. 27: 1761.
Farber, E., MccoNoMY, J., And Frumanski, B., 19676, Relative degrees of labeling of liver Dna and Rna with ethionine, Proc. Am. Assoc. Cancer Res. 8: 16.
Farber, J. L., Shinozuka, H., Serroni, A., And Farmer, R., 1975, Reversal of the ethionine-induced inhibition of rat liver Rna polymerases in vivo by adenine, Lab. Invest. 31: 465.
Feldberg, R. S., And Grossman, L., 1976, A Dna binding protein from human placenta specific for ultraviolet damaged Dna, Biochemistry 15: 2402.
Felsenfeld, G., 1978, Chromatin, Nature (London) 271: 115.
Fiala, E. S., Kulakis, C., Bobotas, G., And Weisburger, J. H., 1976, Separation of 1,2-dimethylhydrazine metabolites by high-pressure liquid chromatography, J. Chromatogr. 117: 181.
Fiala, E. S., Kulakis, C., Christiansen, G., And Weisburger, J. H., 1978, Inhibition of the metabolism of the colon carcinogen, azoxymethane, by pyrazole, Cancer Res. 38: 4515.
Fink, L. M., Nishimura, S., And Weinstein, I. B., 1970, Modifications of ribonucleic acid by chemical carcinogens. I. In vitro modification of transfer ribonucleic acid by N-acetoxy-2-acetylaminofluorene, Biochemistry 9: 496.
Flamm, W. G., Walker, P. M., And Mccallum, M., 1969, Renaturation and isolation of single strands from the nuclear Dna of the guinea pig, J. Mol. Biol. 42: 441.
Floyd, L. R., Unuma, T., And Busch, H., 1968, Effects of aflatoxin B1 and other carcinogens upon nucleolar Rna of various tissues in the rat, Exp. Cell Res. 51: 423.
Fox, M., And Ayad, S. R., 1971, Characteristics of repair synthesis in P388 cells treated with methyl methanesulphonate, Chem. Biol. Interact. 3: 193.
Frei, J. V., Swenson, D. H., Warren, W., And Lawley, P. D., 1978, Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relaation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography, Biochem. J. 174: 1031.
Friedberg, E. C., And Goldthwait, D. A., 1969, Endonuclease II of E. coli. I. Isolation and purification, Proc. Natl. Acad. Sci. Usa 62: 934.
Fuchs, R. P. P., 1975, In vitro recognition of carcinogen-induced local denaturation sites in native Dna by S1 endonuclease from Aspergillus oryzae, Nature (London) 257: 151.
Fuchs, R. P. P., And Daune, M. P., 1974, Dynamic structure of Dna modified with the carcinogen N-acetoxy-N-2-acetyl-aminofluorene, Biochemistry 13: 4435.
Fuchs, R. P. P., Lefevre, J. F., Pouyet, J., And Daune, M. P., 1976, Comparative orientation of the fluorene residue in native Dna, modified by N-acetoxy-N-2-acetylaminofluorene and two 7halogeno-derivatives, Biochemistry 15: 3347.
Fujimura, S., Grunberger, D., Carvajal, G., And Weinstein, I. B., 1972, Modification of Rna by chemical carcinogen. Modification of E. coli formylmethionine tRna with N-acetoxy-2-acetylaminofluorene, Biochemistry 11: 3629.
Fukuda, S., And Yamamoto, N., 1972, Detection of activating enzymes for 4-nitroquinoline-1-oxide activation with a microbiology assay system, Cancer Res. 32: 435.
Furst, A., And Haro, R. T., 1969, Possible mechanisms of metal ion carcinogenesis, in: Physicochemical Mechanisms in Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 ( E. D. Bergmann and B. Pullman, eds.), p. 310, The Israel Academy of Science and Humanities, Jerusalem.
Fuwa, K., Warren, W. E. C., Druyan, R., Bartholomay, A., And Vallee, B. L., 1960, Nucleic acids and metals. II. Transition metals as determinants of the conformation of ribonucleic acids, Proc. Natl. Acad. Sci. Usa 46: 1298.
Galbraith, A. I., Chapleo, M. R., And Itzhaki, R. F., 1978, Distribution of 7-methylguanine and of replication sites in the different kinetic classes of Dna from rats treated with dimethylnitrosamine, Nucleic Acids Res. 5: 3357.
Galbraith, A. I., Barker, M., And Itzhaki, R. F., 1979, Methylation of DNase digestible Dna and of Rna in chromatin from rats treated with dimethylnitrosamine, Biochim. Biophys. Acta 561: 334.
Ganesan, A. K., 1974, Persistence of pyrimidine dimers during post-replication repair in ultraviolet light irradiated Escherichia coli K12, J. Mol. Biol. 87: 103.
Garel, A., And Axel, R., 1976, Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei, Proc. Natl. Acad. Sci. Usa 73: 3966.
Garner, R. C., 1973, Microsomal-dependent binding of aflatoxin-B1 to Dna, Rna, polynucleotides and protein in vitro, Chem. Biol. Interact. 6: 125.
Garner, R. C., Miller, E. C., Miller, J. A., Garner, J. V., And Hanson, R. S., 1971, Formation of a factor lethal for S. typhimurium TA 1530 and TA 1531 on incubation of aflatoxin B1 with rat liver microsomes, Biochem. Biophys. Res. Commun. 45: 774.
Gelboin, H. V., 1969, A microsome-dependent binding of benzo[a]-pyrene to Dna, Cancer Res. 29: 1272.
Gelboin, H. V., Wirlham, J. S., Wilson, R. G., Friedman, M., And Wogan, G. N., 1966, Rapid and marked inhibition of rat liver Rna polymerase by aflatoxin B1, Science 154: 1205.
Gerchman, L. L., And Ludlum, D. B., 1973, The properties of 06-methylguanine in templates for Rna polymerase, Biochim. Biophys. Acta 308: 310.
Gilmour, R. S., And Paul, J., 1973, Tissue specific transcription of the globin gene in isolated chromatin, Proc. Natl. Acad. Sci. Usa 70: 3440.
Ginzburg, I., Cornelis, P., Giveon, D., And Littauer, U. Z., 1979, Functionally impaired Trna from ethionine treated rats as detected in injected Xenopus oocytes, Nucleic Acids Res. 6: 657.
Giovanella, B. C., Mckinney, L. E., And Heidelberger, C., 1964, On the reported solubilization of carcinogenic hydrocarbons in aqueous solutions of Dna, J. Mol. Biol. 8: 20.
Goodman, J. I., And Potter, V. R., 1972, Evidence for Dna repair synthesis and turnover in rat liver following ingestion of 3’-methyl-4-dimethylaminoazobenzene, Cancer Res. 32: 766.
Gorski, J., Morrison, M., Merkel, C. G., And Lingrel, J. B., 1974, Size heterogeneity of polyadeny-late sequences in mouse globin m-Rna, J. Mol. Biol. 86: 363.
Goshman, L. M., And Heidelberger, C., 1967, Binding of tritium-labeled polycyclic hydrocarbons to Dna of mouse skin, Cancer Res. 27: 1678.
Gossard, F., And Verly, W. G., 1978, Properties of the main endonuclease specific for apurinic sites of Escherichia coli (endonuclease VI): Mechanism of apurinic site excision from Dna, Eur. J. Biochem. 82: 321.
Goth, R., And Rajewsky, M. F., 1974a, Persistence of 06-ethylguanine in rat-brain Dna: Correlation with nervous system-specific carcinogenesis by ethyl nitrosourea, Proc. Natl. Acad. Sci. Usa 71: 639.
Goth, R., And Rajewsky, M. F., 1974b, Molecular and cellular mechanisms associated with pulsecarcinogenesis in the rat nervous system by Enu ethylation of nucleic acid; elimination rates of ethylated bases from Dna of different tissues, Z. Krebsforsch. 82: 37.
Gothe, R., Callerman, C. J., Ehrenberg, L., And Watchmeister, C. A., 1976, Trapping with 3,4-dichlorobenzenethiol of reactive metabolites formed in vitro from the carcinogen, vinyl chloride, Ambio 3: 234.
Goth-Goldstein, R., 1977, Repair of Dna damaged by alkylating carcinogens is defective in xeroderma pigmentosum-derived fibroblasts, Nature (London) 267: 81.
Grab, D. J., And Zedeck, M. S., 1977, Organ specific effects of the carcinogen methylazoxymethanol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases, Cancer Res. 37: 4182.
Grab, D. J., Zedeck, M. S., Surstocki, N. I., And Sonenberg, M., 1973, In vitro synthesis of Rna with “aggregate” enzyme, chromatin and Dna from liver of methylazoxymethanol acetate-treated rats, Chem. Biol. Interact. 6: 259.
Green, T., And Hathway, D. E., 1975, The biological fate in rats of vinyl chloride in relation to its oncogenicity, Chem. Biol. Interact. 11: 545.
Green, T., And Hathway, D. E., 1977, The chemistry and biogenesis of the S-containing metabolites of vinyl chloride in rats, Chem. Biol. Interact. 17: 137.
Green, T., And Hathway, D. E., 1978, Interactions of vinyl chloride with rat-liver Dna in vivo, Chem. Biol. Interact. 22: 211.
Grossman, L., Braun, A., Feldberg, R., And Mahler, G., 1975, Enzymatic repair of Dna, Annu. Rev. Biochem. 44: 19.
Grover, P. L., And Sims, P., 1968, Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acids and protein in vitro, Biochem. J. 110: 159.
Grover, P. L., And Sims, P., 1970, Interactions of the K-region epoxides of phenanthrene and dibenz(a,h)anthracene with nucleic acids and histone, Biochem. Pharmacol. 19: 2251.
Grover, P. L., Forrester, J. A., And Sims, P., 1971a, Reactivity of the K-region epoxides of some polycyclic hydrocarbons towards the nucleic acids and proteins of Bhk 21 cells, Biochem. Pharmacol. 20: 1297.
Grover, P. L., Sims, P., Huberman, E., Marquardt, H., Kuroki, T., And Heidelberger, C., 1971b, In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons, Proc. Natl. Acad. Sci. Usa 68:1098.
Grunberger, D., And Weinstein, I. B., 1971, Modifications of ribonucleic acid by chemical carcinogens. Iii. Template activity of polynucleotides modified by N-acetoxy-2-acetylaminofluorene, J. Biol. Chem. 246: 1123.
Grunberger, D., And Weinstein, I. B., 1976, The base displacement model: An explanation for the conformational and functional changes in nucleic acids modified by chemical carcinogens, in: Biology of Radiation Carcinogenesis ( J. M. Yuhas, R. W. Tennat, and J. D. Regan, eds.), p. 175, Raven Press, New York.
Grunberger, D., Nelson, J., Cantor, R. C., And Weinstein, I. B., 1970, Coding and conformational properties of oligonucleotides modified with the carcinogen N-2-acetylaminofluorene, Proc. Natl. Acad. Sci. Usa 66: 488.
Grunberger, G., Yu, F. L., Grunberger, D., And Feigelson, P., 1973, Mechanism of N-hydroxy-2-acetylaminofluorene inhibition of rat hepatic ribonucleic acid synthesis, J. Biol. Chem. 248: 6278.
Hadi, I. S. M., Kirtikar, D., And Goldthwait, D. A., 1973, Endonuclease II of Escherichia coli, degradation of double- and single-stranded deoxyribonucleic acid, Biochemistry 12: 2747.
Haese, W. H., Smith, D. L., And Bueding, E., 1973, Hycanthone induced hepatic changes in mice injected with Schistosoma mansoni, J. Pharmacol. Exp. Ther. 186: 430.
Hagenbuchle, O., Santer, M., Steitz, J. A., And Mans, R. J., 1978, Conservation of the primary structure at the 3’ end of 18s rRna from eukaryotic cells, Cell 13: 551.
Hahn, F. E., (ed.), 1971, Progress in Molecular and Sucellular Biology, Vol. 2, Springer-Verlag, New York.
Hanawalt, P. C., 1972, Repair of genetic material in living cells, Endeavour 31: 83.
Hanawalt, P. C., And Setlow, R. B., (eds.), 1975, Molecular Mechanism for Repair of Dna, Parts A and B, Plenum Press, New York.
Hanawalt, P. C., Cooper, P. K., Ganesan, A. K., And Smith, C. A., 1979, Dna repair in bacteria and mammalian cells, Annu. Rev. Biochem. 48: 783.
Hancock, R. L., 1968, Soluble Rna ethylase activity of normal and neoplastic mouse tissues, Cancer Res. 28: 1223.
Harris, C. C., Conner, R. J., Jackson, F. E., And Lieberman, M. W., 1974, Intranuclear distribution of Dna repair synthesis induced by chemical carcinogens or ultraviolet light in human diploid fibroblasts, Cancer Res. 34: 3461.
Harris, C. C., Autrup, H., Stoner, G., And Trump, B. F., 1978, Model systems using human lung for carcinogenesis studies, in: Pathogenesis and Therapy of Lung Cancer ( C. C. Harris, ed.), p. 559, Marcel Dekker, New York.
Hart, R. W., Setlow, R. B., And Woodhead, A. D., 1977, Evidence that pyrimidine dimers in Dna can give rise to tumors, Proc. Natl. Acad. Sci. Usa 74: 5574.
Hawks, A., Swann, P. F., And Magee, P. N., 1972, Probable methylation of nucleic acids of mouse colon by 1,2-dimethylhydrazine in vivo, Biochem. Pharmacol. 21: 432.
Heath, D. F., 1961, Mechanism of the hepatotoxic action of dialkylnitrosamine, Nature (London) 192: 170.
Hennings, H., And Michael, D., 1976, Guanine-specific Dna repair after treatment of mouse skin cells with N-methyl-N’-nitro-N-nitrosoguanidine, Cancer Res. 36: 2321.
Higgins, N. P., Kato, K., And Strauss, B., 1976, A model for replication repair in mammalian cells, J. Mol. Biol. 101: 417.
Holley, R. W., Apgar, J., Everett, G. A., Madison, J. T., Marquisee, M., Merrill, S. H., Penswick, J. R., And Zamir, A., 1965, Structure of a ribonucleic acid, Science 147: 1462.
Howard-Flanders, P., 1968, Dna repair, Annu. Rev. Biochem. 37: 175.
Hsu, W. T., Lin, E. J., Harvey, R. G., And Weiss, S. B., 1977, Mechanism of phage gX174 Dna inactivation by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, Proc. Natl. Acad. Sci. Usa 74: 3335.
Hsu, W. T., Sagher, D., Lin, E. J., Harvey, R. G., FU, P. P., And Weiss, S. B., 1979, Benzo(a)pyrene7,8-dihydrodiol: Selective binding to single stranded Dna and inactivation of 4X174 Dna infectivity, Biochem. Biophys. Res. Commun. 87: 416.
Huang, P. H. T., And Stewart, B. W., 1977, Differences in patterns of structural change in rat liver Dna following administration of dimethylnitrosamine and methylmethanesulfonate, Cancer Res. 37: 3796.
Huberman, E., And Sachs, L., 1974, Cell-mediated mutagenesis of mammalian cells with chemical carcinogens, Int. J. Cancer 13: 326.
Huberman, E., Aspiras, L., Heidelberger, C., Grover, P. L., And Sims, P., 1971, Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons, Proc. Natl. Acad. Sci. Usa 68: 3195.
Huberman, E., Barstch, H., And Sachs, L., 1975, Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde, Int. J. Cancer 16: 539.
Huberman, E., Sachs, L., Yang, S. K., And Gelboin, H., 1976, Identification of mutagenic metabolite of benzo(a)pyrene in mammalian cells, Proc. Natl. Acad. Sci. Usa 73: 607.
Huggins, C., Grand, L., And Fukinishi, R., 1964, Aromatic influences on the yields of mammary cancers following administration of 7,12-dimethylbenz(a)anthracene, Proc. Natl. Acad. Sci. Usa 51: 737.
Hughes, P. E., And Pilczyk, R., 1969–1970, The in vivo binding of metabolites of 2-naphthylamine to mouse-liver Dna, Rna and protein, Chem. Biol. Interact. 1: 307.
Iball, J., 1939, The relative potency of carcinogenic compounds, Am. J. Cancer 35: 188.
Iball, J., And Macdonald, S. G. G., 1960, The crystal structure of 20-methylcholanthrene, Z. Kristall. Mineral. 114: 439.
Ingold, C. K., 1970, Structure and Mechanism in Organic Chemistry, 2nd ed., pp. 421–555, Bell, London. Iqbal, Z. M., And Epstein, S. S., 1978, Evidence of Dna repair in the guinea pig pancreas in vivo and in vitro following exposure to N-methyl-N-nitrosourethane, Chem. Biol. Interact. 20: 77.
Irving, C. C., 1970, in Metabolic Conjugation and Metabolic Hydrolysis, Vol. 1 (W. H. Fishman, ed.), p. 53, Academic Press, New York.
Irving, C. C., 1971, Metabolic activation of N-hydroxy compounds by conjugation, Xenobiotica 1: 387.
Irving, C. C., 1973, Interaction of chemical carcinogens with Dna, in Methods in Cancer Research, Vol. Vii ( H. Busch, ed.), p. 189, Academic Press, New York.
Irving, C. C., And Russell, L. T., 1970, Synthesis of the O-glucuronide of N-2-fluorenylhydroxyl- amine:Reaction with nucleic acids and with guanosine 5’-monophosphate, Biochemistry 9: 2471.
Irving, C. C., And Veazey, R. A., 1969, Persistent binding of 2-acetylaminofluorene to rat liver Dna in vivo and consideration of the mechanism of binding of N-hydroxy-2-acetylaminofluorene to rat liver nucleic acids, Cancer Res. 27: 1799.
Irving, C. C., Veazey, R. A., And Williard, R. F., 1967, The significance and mechanism of the binding of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene to rat liver ribonucleic acid in vivo, Cancer Res. 27: 720.
Irving, C. C., Veazey, R. A., And Hill, J. T., 1969, Reaction of the glucuronide of the carcinogen N-hydroxy-2-acetylaminofluorene with nucleic acids, Biochim. Biophys. Acta 179: 189.
Irving, C. C., Janss, D. H., And Russell, L. T., 1971, Lack of N-hydroxy-2-acetylaminofluorene sulfotransferase activity in the mammary gland and Zymbal’s gland of the rat, Cancer Res. 31: 387.
Ishizawa, M., And Endo, H., 1967, On the mode of action of a potent carcinogen, 4-hydroxy-laminoquinoline 1-oxide, on bacteriophage T4, Biochem. Pharmacol. 16: 637.
Ivanovic, V., Geacintov, N. E., Yamasaki, H., And Weinstein, I. B., 1978, Dna and Rna adducts formed in hamster embryo cell cultures exposed to benzo(a)pyrene, Biochemistry 17: 1597.
Jahn, C. L., And Litman, G. W., 1977, Distribution of covalently bound benzo(a)pyrene in chromatin, Biochem. Biophys. Res. Commun. 76: 534.
Jahn, C. L., And Litman, G. W., 1979, Accessibility of deoxyribonucleic acid in chromatin to the covalent binding of the chemical carcinogen benzo(a)pyrene, Biochemistry 18: 1442.
Janss, D. H., MooN, R. C., And Irving, C. C., 1972, The binding of 7,12-dimethylbenz(a)anthracene to mammary parenchymal Dna and protein in vivo, Cancer Res. 32: 254.
Jeffrey, A. M., Weinstein, I. B., Jennette, K. W., Grzeskowiak, K., Nakanishi, K., Harvey, R. G., Autrup, H., And Harris, C., 1977, Structure of benzo(a)pyrene nucleic acid adducts formed in human and bovine bronchial explants, Nature (London) 269: 348.
Jeffrey, A. M., Grzeskowiak, K., Weinstein, I. B., Nakanishi, K., Roller, P., And Harvey, R. G., 1979, Benzo(a)pyrene-7,8-dihydrodiol-9–10-oxide adenosine and deoxyadenosine adducts: Structure and stereochemistry, Science 206: 1309.
Jelinek, W., And Darnell, J. E., 1972, Double-stranded regions in heterogeneous nuclear Rna from HeLa cells, Proc. Natl. Acad. Sci. Usa 69: 2537.
Jennette, K. W., Jeffrey, A. M., Blobstein, S. H., Beland, F. A., Harvey, R. G., And Weinstein, I. B., 1977, Nucleoside adducts from the in vitro reaction of benzo(a)pyrene-7–8-dihydrodiol-9,10oxide or benzo(a)pyrene-4,5-oxide with nucleic acids, Biochemistry 16: 932.
Kadlubar, F. F., Miller, J. A., And Miller, E. C., 1978, Guanyl O 6 -arylamination and Os-arylation of Dna by the carcinogen N-hydroxy-1-natphthylamine, Cancer Res. 38: 3628.
Kadlubar, F. F., Dooley, K. L., And Beland, F. A., 1980, Urothelial and hepatic Dna adducts from the carcinogen 2-naphthylamine, Proc. Am. Assoc. Cancer Res. 21: 119.
Kakefuda, T., And Yamamoto, H., 1978, Modification of Dna by the benzo(a)pyrene metabolite diol epoxide, r-7, t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene, Proc. Natl. Acad. Sci. Usa 75: 415.
Kakunaga, T., 1974, Requirement for cell proliferation in the fixation and expression of the transformed state in mouse cells treated with 4-nitroquinoline 1-oxide, Int. J. Cancer 14: 736.
Kanagalingam, K., And Balis, M. E., 1975, In vivo repair of rat intestinal Dna damage by alkylating agents, Cancer 36: 2364.
Kapitulnik, J., Levin, W., Conney, A. J., Yagi, H., And Jerina, D. M., 1977, Benzo(a)pyrene-7,8-dihydrodiol is more carcinogenic than benzo(a)pyrene in newborn mice, Nature (London) 266: 378.
Kappus, H., Bolt, H. M., Buchter, A., And Bolt, W., 1976, Liver microsomal uptake of [14C]-vinyl chloride and transformation of protein by alkylating metabolites in vitro, Toxicol. Appi. Pharmacol. 37: 461.
Kapuler, A. M., And Michelson, A. M., 1971, The reaction of the carcinogen N-acetoxy-2-acetylaminofluorene with Dna and other polynucleotides and its stereochemical implications, Biochim. Biophys. Acta 232: 436.
Karran, P., Lindahl, T., And Griffin, B., 1979, Adaptive response to alkylating agents involves alterations in situ of 06-methylguanine residues in Dna, Nature (London) 280: 76.
Kato, M., And Takalashi, A., 1970, Characteristics of nitro reduction of the carcinogenic agent, 4-nitroquinoline N-oxide, Biochem. Pharmacol. 19: 45.
Kawamata, J., Nakabayashi, N., Kawai, A., And Ushida, T., 1958, Experimental production of sarcoma in mice with actinomycin, Med. J. Osaka Univ. 8: 753.
Kawamata, J., Nakabayashi, N., Kawai, A., Fujita, H., Imanishi, M., And Ikegami, R., 1959, Studies on the carcinogenic effect of actinomycin, Biken J. 2: 105.
Kawamoto, S., Ida, N., Kirschbaum, A., And Taylor, G., 1958, Urethan and leukemogenesis in mice, Cancer Res. 18: 725.
Kawazoe, Y., Araki, M., Aoki, K., And Nakahara, W., 1969, Structure—carcinogenicity relationship among derivatives of 4-nitro and 4-hydroxyaminoquinoline-l-oxides, Biochem. Pharmacol. 16: 631.
Kawazoe, Y., Araki, M., And Huang, G. F., 1972, Chemical aspects of carcinogenesis by 4nitroquinoline 1-oxide, in: Proceedings of the Second International Symposium of the Princess Takamatsu Cancer Research Fund ( W. Nakahara, S. Takayama, T. Sugimura, and S. Odashima, eds.), p. 1, University Park Press, Baltimore.
Kawazoe, Y., Araki, M., Huang, G. F., Okamoto, T., Tada, M., And Tada, M., 1976, Chemical structure of Qaii, one of the covalently bound adducts of carcinogenic 4-nitroquinoline 1-oxide with nucleic acid bases of cellular nucleic acids, Chem. Pharm. Bull. 23: 3041.
King, C. M., And Phillips, B., 1972, Mechanism of introduction of fluorenylamine (FA) substituents into nucleic acid by rat liver, Proc. Am. Assoc. Cancer Res. 13: 43.
King, C. M., Traub, N. R., Lortz, Z. M., And Thissen, M. R., 1979, Metabolic activation of arylhydroxamic acids by N-O-acetyltransferase of rat mammary gland, Cancer Res. 39: 3369.
Kirtikar, D. M., Catheart, G. R., And Goldthwait, D. A., 1976, Endonuclease II. Apurinic acid endonuclease and exonuclease Iii, Proc. Natl. Acad. Sci. Usa 73: 4324.
Kit, S., 1960, Studies on structure, composition, metabolism of tumour Rna in Cell Physiology of New Phases, 14th Annual Symposium on Fundamental Cancer Research, p. 337, M. D. Anderson Hospital and Tumor Institute; University of Texas Press, Austin.
Kleihues, P., 1972, N-Methyl-N-nitrosourea induced changes in the labeling by (14C) orotate of Rna and acid-soluble fractions in rat kidney and liver, Chem. Biol. Interact. 5: 309.
Kleihues, P., And Buecheler, J., 1977, Long-term persistence of O6-methylguanine in rat brain Dna, Nature (London) 269: 625.
Kleihues, P., And Margison, G. P., 1976, Exhaustion and recovery of repair excision of 06methylguanine from rat liver Dna, Nature (London) 259: 153.
Kootstra, A., Slaga, T. J., And Olins, D. E., 1979, Interaction of benzo(a)pyrene diol-epoxide with nuclei and isolated chromatin, Chem. Biol. Interact. 28: 225.
Koreeda, M., Moore, P. D., Wislocki, P. G., Levin, W., Conney, A. H., Yagi, H., And Jerina, D. M., 1978, Binding of benzo(a)pyrene 7,8-dio1–9,10-epoxides to Dna, Rna, and protein of mouse skin occurs with high stereo selectivity, Science 199: 778.
Kornberg, R. D., 1977, Structure of chromatin, Annu. Rev. Biochem. 46: 931.
Kosuge, T., Zenda, H., Yokota, M., Sawanishi, H., And Suzuki, Y., 1969, Further evidence for formation of 4-nitrosoquinoline 1-oxide, Chem. Pharm. Bull. 17: 2181.
Krahn, D. F., And Heidelberger, C., 1977, Liver homogenate-mediated mutagenesis in Chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxins, Mutat. Res. 46: 27.
Kriek, E., 1968, Difference in binding of 2-acetylaminofluorene to rat liver deoxyribonucleic acid and ribosomal ribonucleic acid in vivo, Biochim. Biophys. Acta 161: 273.
Kriek, E., 1969, On the mechanism of action of aromatic amines in vivo. Differences in binding to ribosomal Rna and Dna in Physico-chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 (E. D. Bergmann and B. Pullman, eds.), p. 136, The Israel Academy of Science and Humanities, Jerusalem.
Kriek, E., 1974, Carcinogenesis by aromatic amines, Biochim., Biophys. Acta 355: 177.
Kriek, E., Miller, J. A., Juhl, V., And Miller, E. C., 1967, 8-(N-2-fluorenylacetamide) guanosine, an arylamidation reaction product of guanosine and the carcinogen N-acetoxy-N-2-fluorenyl-acetamide in neutral solution, Biochem. J. 6: 177.
KRÜGer, F. W., 1972, New aspects in metabolism of carcinogenic nitrosamines, in: Proceedings of the Second International Symposium of the Princess Takamatsu Cancer Research Fund ( W. Nakahara, S. Takayama, T. Sugimura, and S. Odashima, eds.), p. 213, University Park Press, Baltimore.
KRÜGer, F. W., 1973, Metabolism of nitrosamines in vivo. II. On the methylation of nucleic acids by aliphatic di-n-alkyl-nitrosamines in vivo, caused by ß-oxidation: The increased formation of 7-methylguanine after application of ß-hydroxypropyl-propyl-nitrosamine compared to that after application of di- n-propyl-nitrosamine, Z. Krebsforsch. 79: 90.
KRÜGer, F. W., And Bertram, B., 1973, Metabolism of nitrosamines in vivo. Iii. On the methylation of nucleic acids by aliphatic di-n-alkyl-nitrosamines in vivo resulting from ß-oxidation: The formation of 7-methylguanine after application of 2-oxo-propyl-propyl-nitrosamine and methylpropyl-nitrosamine, Z. Krebsforsch. 80: 189.
Krugh, T. R., 1972, Association of actinomycin-D and deoxyribonucleotides as a model for binding of the drug to Dna, Proc. Natl. Acad. Sci. Usa 69: 1911.
Kuhnlein, V., Lee, B., Pinhoet, E. E., And Linn, S., 1978, Xeroderma pigmentosum fibroblasts of the D-group lack an apurinic Dna endonuclease species with a low apparent Km, Nucleic Acids Res. 5: 951.
Kuroki, T., And Heidelberger, C., 1971, The binding of polycyclic aromatic hydrocarbons to the Dna, Rna and proteins of transformable cells in culture, Cancer Res. 31: 2168.
Kuroki, T., Huberman, E., Marquardt, H., Selkirk, J. K., Heidelberger, C., Grover, P. L., And Sims, P., 1971–1972, Binding of K-region epoxides and other derivatives of benz(a)anthracene and dibenz(a,h)anthracene to Dna, Rna, and proteins of transformable cells, Chem. Biol. Interact. 4: 389.
Lafarge, C., And Frayssinet, C., 1970, The reversibility of inhibition of Rna and Dna synthesis induced by aflatoxin in rat liver, a tentative explanation for carcinogenic mechanism, Int. J. Cancer 6: 74.
Lancaster, M. C., Jenkins, H. P., And Philips, J. M., 1961, Toxicity a,sociated with certain samples of dry nuts, Nature (London) 192: 1095.
Lanclos, K. D., And Bresnick, E., 1976, The formation of poly-A containing Rna in rat liver after administration of 3-methylcholanthrene, Chem. Biol. Interact. 12: 341.
Laqueur, G. L., And Spatz, M., 1968, Toxicology of cycasin, Cancer Res. 28: 2262.
Laval, J., 1977, Two enzymes are required for strand incision in repair of alkylated Dna, Nature (London) 269: 829.
Laval, J., Pierre, J., And Laval, F., 1981, Release of 7-methylguanine residues from alylated Dna by extracts of Micrococcus luteus and Escherichia coli, Proc. Natl. Acad. Sci. Usa 78: 856.
Lawley, P. D., 1966, Effects of some chemical mutagens and carcinogens on nucleic acids, Prog. Nucleic Acid Res. Mol. Biol. 5: 89.
Lawley, P. D., 1972, The action of alkylating mutagens and carcinogens on nucleic acids: N-methylN-nitroso compounds as methylating agents, in Proceedings of the Second International Symposium of the Princess Takamatsu Cancer Research Fund ( W. Nakahara, S. Takayama, T. Sugimura, and S. Odashima, eds.), p. 237, University Park Press, Baltimore.
Lawley, P. D., 1973, Reaction of N-methyl-N-nitrosourea (Mnua) with 32P-labelled Dna: Evidence for formation of phosphotriesters, Chem. Biol. Interact. 7: 127.
Lawley, P. D., 1974, Some chemical aspects of dose–response relationships in alkylation mutagenesis, Mutat. Res. 23: 283.
Lawley, P. D., 1976, Carcinogenesis by alkylating agents, in Chemical Carcinogens (C. E. Searle, ed.), p. 83, Acs Monograph 173, Washington, D.C.
Lawley, P. D., And Brookes, P., 1963, Further studies on the alkylation of nucleic acids and their constituent nucleotides, Biochem. J. 89: 127.
Lawley, P. D., And Orr, D. J., 1970, Specific excision of methylation products from Dna of Escherichia coli treated with N-methyl-N’-nitro-N-nitrosoguanidine, Chem. Biol. Interact. 2: 154.
Lawley, P. D., And Shah, S. A., 1972, Methylation of ribonucleic acid by the carcinogens dimethylsulfate, N-methyl-N-nitrosourea and N-methyl-N’ -nitro- N-nitrosoguanidine: Comparisons of chemical analysis at the nucleoside and base levels, Biochem. J. 128: 117.
Lawley, P. D., And Shah, S. A., 1973, Methylation of Dna by 3H–14C-methyl-labelled N-methyl-Nnitrosourea—evidence for transfer of the intact methyl group, Chem. Biol. Interact. 7: 115.
Lawley, P. D., And Thatcher, C. J., 1970, Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N’ -nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 06-oxygen atom of guanine as a site of methylation, Biochem. J. 116: 693.
Lawley, P. D., And Warren, W., 1975, Specific excision of ethylated purines from Dna of Escherichia coli treated with N-ethyl-N-nitrosourea, Chem. Biol. Interact. 11: 55.
Lawley, P. D., Brookes, P., Magee, P. N., Craddock, V. M., And Swann, P. F., 1968, Methylated bases in liver nucleic acids from rats treated with dimethylnitrosamines, Biochim. Biophys. Acta 157: 646.
Lawley, P. D., Orr, D. J., And Shah, S. A., 1971–1972, Reaction of alkylating mutagens and carcinogens with nucleic acids: N-3 of guanine as a site of alkylation by N-methyl-N-nitrosourea and dimethylsulfate, Chem. Biol. Interact. 4: 431.
Lawley, P. D., Orr, D. J., Shah, S. A., Farmer, P. B., And Jarman, M., 1973, Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues: Synthesis and identification of a new methylation product, 04-methylthymidine, Biochem. J., 135: 193.
Lawson, T. A., 1968, The binding of 0-aminoazotoluene to deoxyribonucleic acid, ribonucleic acid and protein in the C57 mouse, Biochem. J. 109: 917.
Lawson, T. A., And Calyson, D. B., 1969, Differences in binding of orthoaminoazotoluene to macromolecules in female and male C57 mouse liver, in Physico-chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 ( E. D. Bergmann and B. Pullman, eds.), p. 226, The Isreal Academy of Science and Humanities, Jerusalem.
Lawson, T. A., And Pound, A. W., 1971–1972, The interaction of (3H) ethyl carbamate with nucleic acids of regenerating mouse liver, Chem. Biol. Interact. 4: 329.
Lawson, T. A., And Pound, A. W., 1973a, The interaction of carbon-14-labeled alkyl carbamates, labeled in the alkyl- and carbonyl-positions, with Dna in vivo, Chem. Biol. Interact. 6: 99.
Lawson, T. A., And Pound, A. W., 1973b, The prolonged binding of ethyl carbamate-(14C) to Dna in regenerating and intact mouse liver, Eur. J. Cancer 9: 491.
Lee, K. Y., And Lijinsky, W., 1966, Alkylation of rat liver Rna by cyclic N-nitrosamines in vivo, J. Natl. Cancer Inst. 37: 401.
Leffler, S., Pulkrabek, P., Grunberger, D., And Weinstein, I. B., 1977, Template activity of calf thymus Dna modified by a dihydrodiol epoxide derivative of benzo(a)pyrene, Biochemistry 16: 3133.
Lerman, L. S., 1964, Acridine mutagens and Dna structure J. Cell. Comp. Physiol. 64: 1
Lerman, L. S., 1971, Intercalability, the “y” transition, and the state of Dna in nature, in Progress in Molecular and Subcellular Biology, Vol. 2 ( F. E. Hahn, ed.), p. 382, Springer-Verlag, New York.
Lett, J. T., Parkins, G. M., And Alexander, P., 1962, Physiochemical changes produced in Dna after alkylation, Arch Biochem. Biophys. 97: 80.
Lett, J. T., Klucis, E. S., And Sun, C., 1970, On the size of the Dna in the mammalian chromosome substructural subunits, Biophys. J. 10: 277.
Levine, A. F., Fink, L. M., Weinstein, I. B., And Grunberger, D., 1974, Effect of N-2-acetylaminofluorene modification on the conformation of nucleic acids, Cancer Res. 34: 319.
Levy, C. C., Schmukler, M., Frank, J. J., Karpetsky, T. P., Jewett, P. B., Hieter, P. A., Legandre, S. M., And Dorris, G., 1975, Possible role of poly(A) as an inhibitor of endonuclease activity in eukaryotic cells, Nature (London) 256: 340.
Lieberman, M. W., And Poirer, M. C., 1974a, Distribution of deoxyribonucleic acid repair synthesis among repetitive and unique sequences in the human diploid genome, Biochemistry 13: 3018.
Lieberman, M. W., And Poirer, M. C., 1974b, Intragenomal distribution of Dna repair synthesis: Repair in satellite and main band Dna in cultured mouse cells, Proc. Natl. Acad. Sci. Usa 71: 2461.
Lijinsky, W., Loo, J., And Ross, A. E., 1968, Mechanism of alkylation of nucleic acids by nitrosodimethylamine, Nature (London) 218: 1174.
Lilja, H. S., Curphey, T. J., Yager, J. D., JR., And Longnecker, D. S:, 1978, Persistence of Dna damage in rat pancreas following administration of three carcinogens and/or mutagens, Chem. Biol. Interact. 22: 287.
Lin, J. K., Miller, J. A., And Miller, E. C., 1977, 2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin BI, a major acid hydrolysis product of aflatoxin-B1-Dna or ribosomal-Rna adducts formed in hepatic microsome mediated reactions and in rat liver in vivo, Cancer Res. 37:4430.
Lingens, F., Haerlin, F., And Sussmuth, R., 1971, Mechanisms of mutagenesis by N-methyl-N’nitro-N-nitrosoguanidine (Mnng). Methylation of nucleic acids by N-trideuteriomethyl-N’ -nitroN-nitrosoguanidine (D3-Mnng) in the presence of cysteine and in cells of Escherichia coli, Febs Lett. 13: 241.
Linsley, W. S., Penhoet, E. E., And Linn, S., 1977, Human endonuclease specific for apurinic/apyrimidinic sites in Dna. Partial purification and characterization of multiple forms from placenta, J. Biol. Chem. 252: 1235.
Liquori, A. M., Delerma, B., Ascoli, F., BotrÉ, C., And Trascitti, M., 1962, Interaction between Dna and polycyclic aromatic hydrocarbons, J. Mol. Biol. 5: 521.
Liquori, A. M., Costantino, L., And Crescezi, V., 1967, Complexes between Dna and polyamides: “A molecular model,” J. Mol. Biol. 24: 113.
Ljungquist, S., And Lindahl, T., 1977, Relation between Escherichia coli endonucleases specific for apurinic sites in Dna and exonuclease Iii, Nucleic Acids Res. 4: 2871.
Lotlikar, P. D., And Luha, L., 1971a, Enzymatic N-acetylation of N-hydroxy-2-aminofluorene of liver cytosol from various species, Biochem. J. 123: 287.
Lotlikar, P. D., And Luha, L., 1971 b, Acylation of carcinogenic hydroxamic acids by carbamoylphosphate to form reactive esters, Biochem. J. 124: 69.
Loveless, A., 1969, Possible relevance of 06 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides, Nature (London) 223: 206.
Lutz, W. K., 1979, In vivo covalent binding of organic chemicals to Dna as a quantitative indicator in the process of chemical carcinogenesis, Mutat. Res. 65: 289.
Lytle, C. D., Day, R. S., Hellman, K. B., And Bockstahler, L. E., 1976, Infection of UV irradiated xeroderma pigmentosum fibroblasts by herpes-simplex-virus: Study of capacity and Weigle reactivation, Mutat. Res. 36: 257.
Lytle, C. D., Coppey, J., And Taylor, W. D., 1978, Enhanced survival of ultraviolet-irradiated herpes-simplex virus in carcinogen pretreated cells, Nature (London) 272: 60.
Magee, P. N., And Barnes, J. M., 1967, Carcinogenic nitroso compounds, Adv. Cancer Res. 10: 163.
Magee, P. N., And Farber, E., 1962, Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivo, Biochem. J. 83: 114.
Magee, P. N., And Hultin, T., 1962, Toxic liver injury and carcinogenesis. Methylation of rat liver slices by dimethylnitrosamine in vitro, Biochem. J. 83: 106.
Magee, P. N., And Lee, K. Y., 1963, Experimental toxic liver injury by some nitrosamines, Ann. N.Y. Acad. Sci. 104: 916.
Magee, P. N., And Lee, K. Y., 1964, Cellular injury and carcinogenesis: Alkylation of ribonucleic acid of rat liver by diethylnitrosamine and n-butylmethylnitrosamine in vivo, Biochem. J. 91: 35.
Magee, P. N., And Schoental, R., 1964, Carcinogenesis by nitroso compounds, Br. Med. Bull. 20: 102.
Maher, V. M., Douville, D., Tomura, T., And Van Lancker, J. L., 1974, Mutagenicity of reactive derivatives of carcinogenic hydrocarbons: Evidence of Dna repair, Mutat. Res. 23: 113.
Malaveille, C., Bartsch, H., Barbina Camus, A. M., Montesano, R., Croisy, A., And Jacquignon, P., 1975, Mutagenicity of vinyl chloride, chloroethylene oxide, chloroacetaldehyde and chloroethanol, Biochem. Biophys. Res. Commun. 63: 363.
Malkin, M. F., And Zahalsky, A. C., 1966, Interaction of the water-soluble carcinogen 4-nitroquinoline N-oxide with Dna, Science 154: 1665.
Margison, G. P., And Pegg, A. E., 1981, Enzymatic release of 7-methylguanine from methylated Dna by rodent liver extracts, Proc. Natl. Acad. Sci. Usa 78: 861.
Margison, G. P., Capps, M. J., O’Connor, P. J., And Craig, A. W., 1973, Loss of 7-methylguanine from rat liver Dna after methylation in vivo with methylmethanesulphonate or dimethylnitrosamine, Chem. Biol. Interact 6: 119.
Marquartdt, H., Bendich, A., Philips, F. S., And Hoffmann, D., 1971, Binding of G-5H-7,12dimethylbenz(n)anthracene to Dna of normal and rapidly dividing hepatic cells of rats, Chem. BioL Interact. 3: 1.
Marroquin, F., And Farber, E., 1965, The binding of 2-acetylaminofluorene to rat liver ribonucleic acid in vivo, Cancer Res. 25: 1262.
Martin, C. N., And Garner, R. C., 1977, Aflatoxin B1 oxide generated by chemical or enzymic oxidation of aflatoxin B1 causes guanine substitution in nucleic acids, Nature (London) 267: 863.
Matsumoto, H., And Higa, H. H., 1966, Studies on methylazoxymethanol, the aglycone of cycasin: Methylation of nucleic acids in vitro, Biochem. J. 98: 20C.
Matsushima, T., Kobuna, I., And Sugimura, T., 1967, In vivo interaction of 4-nitroquinoline-1-oxide and its derivatives with Dna, Nature (London) 216: 508.
Matsuyama, A., And Nagata, C., 1972, Detection of the unstable intermediate 4-nitrosoquinoline-1oxide, in: Proceedings of the Second International Symposium of the Princess Takamatsu Cancer Resarch Fund ( W. Nakahara, S. Takayama, T. Sugimura, and S. Odashima, eds.), p. 35, University Park Press, Baltimore.
Mccalla, D. R., Reuvers, A., And Kitai, R., 1968, Inactivation of biologically active N-methyl-Nnitroso compounds in aqueous solution: Effect of various conditions of pH and illumination, Can. J. Biochem. 46: 807.
Mccalla, D. R., Reuvers, A., And Kaiser, C., 1971, Activation of nitrofurazone in animal tissues, Biochem. PharmacoL 20: 3532.
Mccann, J., Simon, V., Streitwiser, D., And Ames, B. N., 1975, Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene-dichloride), chloroethanol (ethylenechlorohydrin), vinyl chloride and cyclophosphamide, Proc. NatL Acad. Sci. Usa 72: 3190.
Mccann, J., CHoi, E., Yamasaki, E., And Ames, B. N., 1976, Detection of carcinogens as mutagens in the Salmonellalmicrosome test: Assay of 300 chemicals, Proc. NatL Acad. Sci. Usa 72: 5135.
Mcentee, K., Weinstock, G. M., And Lehman, I. R., 1979, Initiation of general recombination catalyzed in vitro by the Rec.A protein of E. coli. Proc. NatL Acad. Sci. Usa 76: 2615.
Mcentee, K. Weinstock, G. M., And Lehman, I. R., 1980, Rec.A protein-catalyzed strand assimilation: Stimulation by Escherichia coli single stranded Dna-binding protein, Proc. Natl. Acad. Sci. Usa 77: 857.
Meehan, T., And Straub, K., 1979, Double-stranded Dna stereoselectively binds benzo(a)pyrene diol epoxides, Nature (London) 277: 410.
Mengle, L., Gamper, H., And Bartholomew, J., 1978, Base specificity in the binding of benzo(a)pyrene diol epoxide to simian virus 40 Dna, Cancer Lett. 5: 131.
Metzger, G., And Daune, M., 1975, In vitro binding of N-acetoxy-N-2-acetylaminofluorene to Dna in chromatin, Cancer Res. 35: 2738.
Metzger, G., Wilhelm, F. X., And Wilhelm, M. L., 1976, Distribution along Dna of the bound carcinogen N-acetoxy-N-2-acetylaminofluorene in chromatin modified in vitro, Chem. BioL Interact. 15: 257.
Metzger, G., Wilhelm, F. X., And Wilhelm, M. L., 1977, Non-random binding of a chemical carcinogen to the Dna in chromatin, Biochem. Biophys. Res. Commun. 75: 703.
Michael, R. O., Parodi, S., And Sarma, D. S. R., 1975, In vivo repair of rat liver Dna damaged by 3-hydroxyxanthine, Chem. BioL Interact. 10: 19.
Miller, E. C., And Miller, J. A., 1969, Studies on the mechanism of activation of aromatic amine and amide carcinogens to ultimate carcinogenic electrophilic reactants, Ann. N.Y. Acad. Sci. 163: 731.
Miller, E. C., And Miller, J. A., 1971, The mutagenicity of chemical carcinogens: Correlations, problems and interpretations, in: Chemical Mutagens: Principles and Methods for Their Detection, Vol. I (A. Hollaender, ed.) p. 83, Plenum Press, New York.
Miller, J A., 1970, Carcinogenesis by chemicals: An overview—G. H. A. Clowes memorial lecture, Cancer Res. 30: 559.
Miller, J. A., And Miller, E. C., 1969, Metabolic activation of carcinogenic aromatic amines and amides via N-hydroxylation and N-hydroxy-esterification and its relationship to ultimate carcinogens as electrophilic reactants, in: Physico-chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 ( E. D. Bergmann and B. Pullman, eds.), p. 237, The Israel Academy of Science and Humanities, Jerusalem.
Miller, J. A., Lin, J.-K., And Miller, E. C., 1970, N-(guanosin-8-yl) and N-(deoxyguanosin-8-yl)-Nmethyl-4-aminoazobenzene: Degradation products of hepatic Rna and Dna in rats administered N’-methyl-4-aminoazobenzene, Proc. Am. Assoc. Cancer Res. 11: 56.
Mirvish, S. S., 1968, The carcinogenic action and metabolism of urethan and N-hydroxyurethan, Adv. Cancer Res. 11: 1.
Miura, K., And Reckendorf, H. K., 1967, The nitrofurans, Frog. Med. Chem. 5: 320.
Miyaki, M., Yatagai, K., And Ono, T., 1977, Strand breaks of mammalian mitochondrial Dna induced by carcinogens, Chem. Biol. Interact. 17: 321.
Mizusawa, H., And Kakefuda, T., 1979, Inhibition of Dna synthesis in vitro by binding of benzo(a)pyrene metabolites diol-epoxide I to Dna, Nature (London) 279: 75.
Montesano, R., BRÉSil, H., And Margison, G., 1979, Increased excision of 06-methylguanine from rat liver Dna after chronic administration of dimethylnitrosamine, Cancer Res. 39: 1798.
Moore, P., And Strauss, B. S., 1979, Sites of inhibition of in vitro Dna synthesis in carcinogen and UV-treated gX174 Dna, Nature (London) 278: 664.
Moreau, P., Bailone, A., And Devoret, R., 1976, Prophage À induction in E. coli K12 envA uvrB: A highly sensitive test for potential carcinogens, Proc. Natl. Acad. Sci. Usa 73: 3700.
Morita, T., Fukunaga, M., And Mifuchi, I., 1976, Loss of mitochondrial Dna in respiration deficient mutant of yeast induced by 4-nitroquinoline 1-oxide, Gann 66: 697.
Moses, H. L., Webster, R. A., Martin, G. D., And Spelsberg, T. C., 1976, Binding of polycyclic aromatic hydrocarbons to transcriptionally active nuclear subfractions of Akr mouse embryo cells, Cancer Res. 36: 2905.
Moyer, G. H., Gumbiner, B., And Austin, G. E., 1977, Binding of N-hydroxy-2-acetylaminofluorene to eu- and heterochromatin fractions of rat liverin vivo, Cancer Lett. 2: 259.
Mulivor, R. A., Abanobi, S. E., And Sarma, D. S. R., 1974, Hepatic Dna damage induced by methylmethanesulfonate (Mms) and dimethylnitrosamine (Dmn) in vivo, Proc. Am. Assoc. Cancer Res. 15: 85.
MÜLler, W., And Crothers, D. M., 1968, Studies on the binding of actinomycin and related compounds to Dna, J. MoL BioL 35: 251.
Myles, A., And Brown, G. B., 1969, Purine N-oxides. Xxx. Biochemical studies of the oncogen 3-hydroxyxanthine, J. BioL Chem. 244: 4072.
Nagasawa, H. T., Shirota, F. N., And Matsumoto, H., 1972, Decomposition of methylazoxymethanol, the aglycone of cycasin, in D20, Nature (London) 236: 234.
Nagata, C., Kataoka, N., Imamura, A., Kawazoe, Y., And Chihara, G., 1966, Electronic spin resonance study on the free radicals produced from 4-hydroxyaminoquinoline 1-oxide and its significance in carcinogenesis, Gann 57: 323.
Nagata, Y., And Matsumoto, H., 1969, Studies on methylazoxymethanol: Methylation of nucleic acids in the fetal rat brain, Proc. Soc. Exp. Biol. Med. 132: 383.
Nakahara, W., Fukuoka, F., And Sugimura, T., 1957, Carcinogenic action of 4-nitroquinoline 1-oxide, Gann 48: 129.
Nakanishi, K., Kasai, H., Cho, H., Harvey, R. G., Jeffrey, A. M., Jennette, K. W., And Weinstein, I. B., 1977, Absolute configuration of a ribonucleic acid adduct formed in vivo by metabolism of benzo(a)pyrene, J. Am. Chem. Soc. 99: 258.
Natori, Y., 1963, VI. Sex-dependent behavior of methionine and ethionine in rats, J. Biol. Chem. 238: 2075.
Nelson, J. H., Grunberger, D., Canto, C. R., And Weinstein, I. B., 1971, Modification of ribonucleic acid by chemical carcinogens. IV. Circular dichroism and proton magnetic resonance studies of oligonucleotides modified with N-2-acetylaminofluorene, J. Mol. Biol. 62: 331.
Nery, R., 1968, Some aspects of the metabolism of urethane and N-hydroxyurethane in rodents, Biochem. J. 106: 1.
Nery, R., 1969, Acylation of cytosine by ethyl N-hydrocarbamate and its acyl derivatives and the binding of these agents to nucleic acids and proteins, J. Chem. Soc. C 1969: 1860.
Nicolini, C., Ramanathan, R., Kendall, F., Murphy, J., Parodi, S., And Sarma, D. S. R., 1976, Physicochemical alterations in the conformation of rat liver chromatin induced by carcinogens in vivo, Cancer Res. 36: 1725.
Nicoll, J. W., Swann, P. F., And Pegg, A. E., 1977, The accumulation of O6-methylguanine in the liver and kidney Dna of rats treated with dimethylnitrosamine for a short or a long period, Chem. Biol. Interact. 16: 301.
Noll, M., 1974, Subunit structure of chromatin, Nature (London) 251: 249.
Nomura, T., 1976, Diminution of tumorigenesis initiated by 4-nitroquinoline 1-oxide by posttreatment with caffeine in mice, Nature (London) 260: 547.
Nomura, T., 1980, Timing of chemically induced neoplasia in mice revealed by the antineoplastic action of caffeine, Cancer Res. 40: 1332.
O’Connor, P. J., Capps, M. J., And Craig, A. W., 1973, Comparative studies of the hepatocarcinogen N,N-dimethylnitrosamine in vivo: Reaction sites in rat liver Dna and the significance of their relative stabilities, Br. J. Cancer 27: 153.
Oleson, F. B., Mitchell, B. L., Dipple, A., And Lieberman, M. W., 1979, Distribution of Dna damage in chromatin and its relation to repair in human cells treated with 7-bromomethylbenzo(a)anthracene, Nucleic Acids Res. 7: 1343.
Ornstein, R. C., And Rein, R., 1979, Nucleic acid base and carcinogen metabolites specificities during intercalative interactions between Dna and 4Nqo, Chem. Biol. Interact. 27: 291.
Ortwerth, B. J., And Novelli, G. D., 1969, Studies on the incorporation of L-ethionine-ethyl-1–14C into the transfer Rna of rat liver, Cancer Res. 29: 380.
Osborne, M. R., Harvey, R. G., And Brookes, P., 1978, The reaction of trans-7,8-dihydroxy-anti9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with Dna involves attack at the N-7 position of guanine moieties, Chem. Biol. Interact. 20: 123.
Osterman Golkar, S., Ehrenberg, L., And Wachtmeister, C. W., 1970, Reaction kinetics and biological action in barley of monofunctional methanesulfonic esters, Radial. Bot. 10: 303.
Painter, R. B., 1970, Repair of Dna in mammalian cells, Curr. Top. Radial. Res. 7: 45.
Painter, R. B., 1978, Does ultraviolet light enhance postreplication repair in mammalian cells?, Nature (London) 275: 243.
Park, S. D., And Cleaver, J. E., 1979, Postreplication repair: Question of its definition and possible alteration in xeroderma pigmentosum cell strains, Proc. Natl. Acad. Sci. Usa 76: 3927.
Parodi, S., Taningher, M., Santi, L., Cananna, M., Sciaba, L., Maura, A., And Brambilla, G., 1978, A practical procedure for testing Dna damage in vivo, proposed for a prescreening of chemical carcinogens, Mutat. Res. 54: 39.
Patel, N. T., And Holoubek, V., 1976, Protein composition of liver nuclear ribonuclear protein particles of rats fed carcinogenic amino azo-dyes, Biochem. Biophys. Res. Commun. 73: 112.
Paterson, M. C., Smith, B. P., Lohman, P. H. M., Anderson, A. K., And Fishman, L., 1976, Defective excision repair of X-ray damaged Dna in human (ataxia telangiectasia) fibroblasts, Nature (London) 260: 444.
Paul, H. E., And Paul, M. F., 1964, The nitrofurans—Chemotherapeutic properties, in: Experimental Chemotherapy, Vol. II ( R. J. Schnitzer and F. Hawkins, eds.), p. 307, Academic Press, New York.
Paul, J. S., Montgomery, P. O’B., JR., And Louis, J. B., 1971, A proposed model of the interaction of 4-nitroquinoline 1-oxide with Dna, Cancer Res. 31: 413.
Pauling, L., 1970, General Chemistry, Freeman, San Francisco.
Pegg, A. E., 1972, Ethylation of rat liver t-Rna after administration of L-ethionine, Biochem. J 128: 59.
Pegg, A. E., 1973, Alkylation of transfer Rna by N-methyl-N-nitrosourea and N-ethyl-Nnitrosourea, Chem. Biol. Interact. 6: 393.
Pegg, A. E., 1978a, Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2dimethylhydrazine by amino acetonitrile, Chem. Biol. Interact. 23: 273.
Pegg, A. E., 1978b, Enzymatic removal of 06-methylguanine from Dna by mammalian cell extracts, Biochem. Biophys. Res. Commun. 84: 166.
Pegg, A. E., And Hui, G., 1978, Removal of methylated purines from rat liver Dna after administration of dimethylnitrosamine, Cancer Res. 38: 2011.
Pegg, A. E., And Jackson, A., 1976, Alkylation of messenger Rna by dimethylnitrosamine, Chem. Biol. Interact. 12: 279.
Phillips, D. H., Miller, J. A., Miller, E. C., And Adams, B. 1981, N2 atom of guanine and N6 atom of adenine residues as sites for covalent binding of metabolically activated 1’-hydroxy safrole to mouse liver Dna in vivo, Cancer Res. 41: 2664.
Pochon, F., And Michelson, A. M., 1971, Action of the carcinogen 7-bromomethylbenz(a)anthracene on synthetic polynucleotides, Eur. J. Biochem. 21: 144.
Poirier, L. A., Miller, J. A., Miller, E. C., And Sato, K., 1967, N-Benzoyloxy-N-methyl-4aminoazobenzene. Its carcinogenic activity in the rat and its reactions with proteins and nucleic acids and their constituents in vitro, Cancer Res. 27: 1600.
Pong, R. S., And Wogan, G. N., 1970, Time course and dose—response characteristics of aflatoxin B1 effects on rat liver Rna polymerase and ultrastructure, Cancer Res. 30: 294.
Pound, A. W., Franke, F., And Lawson, T. A., 1976, Binding of ethyl carbamate to Dna of mouse liver in vivo. The nature and site of binding, Chem. Biol. Interact. 14: 149.
Powers, D. M., And Holley, R. W., 1972, Selective chemical methylation of yeast alanine transfer Rna, Biochim. Biophys. Acta 287: 456.
Prakash, L., And Strauss, B., 1970, Repair of alkylation damage: Stability of methyl groups in Bacillus subtilis treated with methylmethanesulfonate, J. Bacteriol. 102: 760.
Preussmann, R., Druckrey, H., Ivankovic, S., And Hodenberg, A. V., 1967, Chemical structure and carcinogenicity of aliphatic hydrazo, azo and azoxy compounds and of triazenes, potential in vivo alkylating agents, Ann. N.Y. Acad. Sci. 163: 697.
Prodi, G., Rocchi, P., And Grilli, S., 1970a, In vivo interaction of urethan with nucleic acids and proteins, Cancer Res. 30: 2887.
Prodi, G., Rocchi, P., And Grilli, S., 1970b, Binding of 7,12-dimethylbenz(a)anthracene and benzopyrene to nucleic acids and proteins of organs in rats, Cancer Res. 30: 1020.
Pulkrabek, P., Leffler, S., Grunberger, D., And Weinstein, I. B., 1979, Modification of deoxyribonucleic acid by a diol epoxide of benzo(a)pyrene. Relation to Dna structure and conformation and effects on transfectional activity, Biochemistry 18: 5128.
Pullman, B., And Pullman, A., 1959, The electronic structure of the purine—pyrimidine pairs of Dna, Biochim. Biophys. Acta 36: 343.
Rages, H. M., Realer, R., Wilhelm, R., Rode, G., And Riess, H., 1979, Alkylation of Dna and Rna by [14C] dimethylnitrosamine in hydroxyurea synchronized regenerating rat liver, Cancer Res. 39: 4228.
Radman, M., 1974, in: Molecular and Environmental Aspects of Mutagenesis (L. Prakash, F. Sherman, M. W., Miller, C. W. Lawrence, And H. W. Teber, eds.), p. 128, Thomas, Springfield, Ill.
Rajalakshmi, S., 1973, A liver tRna for the assay of rat liver methylase in vitro, Proc. Am. Assoc. Cancer Res. 14: 39.
Rajalakshmi, S., And Sarma, D. S. R., 1973, Rapid repair of hepatic Dna damage induced by camptothecin in the intact rat, Biochem. Biophys. Res. Commun. 53: 1268.
Rajalakshmi, S., And Sarma, D. S. R., 1975, Replication of hepatic Dna in rats treated with dimethylnitrosamine, Chem. Biol. Interact. 11: 245.
Rajalakshmi, S., Rao, P. M., And Sarma, D. S. R., 1978a, Modulation of carcinogen chromatin Dna interaction by polyamines, Biochem. Biophys. Res. Commun. 81: 936.
Rajalakshmi, S., Rao, P. M., And Sarma, D. S. R., 1978, Studies on carcinogen chromatin-Dna interaction: Inhibition of N-methyl-N-nitrosourea-induced methylation of chromatin-Dna by spermine and distamycin-A, Biochemistry 17: 4515.
Rajalakshmi, S., Rao, P. M., And Sarma, D. S. R., 1980, Carcinogen—Dna interaction: Differential effects of distamycin-A and spermine on the formation of 7-methylguanine in Dna by N-methyl-Nnitrosourea, methylmethanesulfonate and dimethylsulfate, Teratogenesis Carcinogenesis and Mutagenesis 1: 97.
Ramanathan, R., And Dipple, A., 1976, Specificity of interaction of directly acting carcinogens with Dna, Proc. Am. Assoc. Cancer Res. 17: 77.
Ramanathan, R., Rajalakshmi, S., Sarma, D. S. R., And Farber, E., 1976a, Non-random nature of in vivo methylation by dimethylnitrosamine and subsequent removal of methylated products from rat liver chormatin Dna, Cancer Res. 36: 2073.
Ramanathan, R., Rajalakshmi, S., And Sarma, D. S. R., 1976b, Non-random nature of in vivo interaction of 3H-N-hydroxy-2-acetylaminofluorene and its subsequent removal from rat liver chromatin Dna, Chem. Biol. Interact. 14: 375.
Ramstein, J., HoussIer, C., And Leng, M., 1973, Electro-optical properties of nucleic acids and nucleoproteins, IV. Influence of base composition and methylation on the properties of Dna and Dna—proflavin complexes, Biochim. Biophys. Acta 335: 54.
Rao, P. M., Rajalakshmi, S., And Sarma, D. S. R., 1978, Carcinogen induced alterations in DNase I rlease of N5-methyladenine from liver chromatin, Chem. Biol. Interact. 22: 347.
Regan, J. D., And Setlow, R. B., 1974, Two forms of repair in the Dna of human cells damaged by chemical carcinogens and mutagens, Cancer Res. 34: 3318.
Reid, B. D., And Walker, I. G., 1969, The response of mammalian cells to alkylating agents. II. On the mechanism of the removal of sulfur-mustard-induced crosslinks, Biochim. Biophys. Acta 179: 179.
Reiner, B., And Zamenhof, S., 1957, Studies on the chemically reactive groups of deoxyribonucleic acids, J. Biol. Chem. 228: 475.
Renard, A., Thibodeau, L., And Verly, W. G., 1978, O6-Ethylguanine excision from Dna of liver nuclei treated with ethylnitrosourea, Fed. Proc. 37: 1412.
Rhaese, H. J., And Freese, E., 1969, Chemical analysis of Dna alteration. IV. Reactions of oligodeoxynucleotides with monofunctional alkylating agents leading to backbone breakage, Biochim. Biophys. Acta 190: 418.
Riazuddin, S., And Lindahl, T., 1978, Properties of 3-methyl-adenine-Dna glycosylase from Escherichia coli, Biochemistry 17: 2110.
Roberts, J. J., 1969, The binding of metabolites of 4-dimethylaminoazobenzene and 2-methyl-4dimethylaminoazobenzene to hooded rat macromolecules during chronic feeding, in: Physicochemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 (E. D. Bergmann and B. Pullman, eds.), p. 229, The Israel Academy of Science and Humanities, Jerusalem.
Roberts, J. J., 1972, Repair of alkylated Dna in mammalian cells, in: Molecular and Cellular Repair Processes ( R. F. Beers, R. M. Herriott, and R. C. Tilghman, eds.), p. 226, The Johns Hopkins Press, Baltimore.
Roberts, J. J., 1978, The repair of Dna modified by cytotoxic, mutagenic and carcinogenic chemicals, Adv. Radiat. Bio. 7: 211.
Roberts, J. J., And Warwick, G. P., 1961, Reactions of 5H-labelled butter yellow in vivo and N-hydroxy-methylaminoazobenzene in vitro, Biochem. J. 93: 1897.
Roberts, J. J., And Warwick, G. P., 1963, The reaction of ß-propiolactone with guanosine, deoxyguanylic acid and Rna, Biochem. Pharmacol. 12: 1441.
Roberts, J. J., And Warwick, G. P., 1966, The covalent binding of metabolites of dimethyl-aminoazobenzene, ß-naphthylamine and aniline to nucleic acids in vivo, Int. J. Cancer 1: 179.
Robins, P., And Cairns, J., 1979, Quantitation of the adaptive response to alkylating agents, Nature (London) 280: 74.
Rodriguez, L. V., And Becker, F. F., 1976, Rat liver chromatin, fractionation into eu- and hetero-chromatin with localization of ribosomal genes, Arch. Biochem. Biophys. 173: 428.
Rosen, L., 1968, Ethylation in vivo of purines in rat liver t-Rna by L-ethionine, Biochem. Biophys. Res. Commun. 33: 546.
Rothwell, K., 1974, Dose related inhibition of chemical carcinogenesis in mouse skin by caffeine, Nature (London) 252: 69.
RuPP, W. D., And Howard-Flanders, P., 1968, Discontinuities in the Dna synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation, J. Mol. Biol. 31: 291.
Ryskov, A. P., Farashyan, V. R., And Georgiev, G. P., 1972, Ribonuclease-stable base sequences specific exclusively for giant dRna, Biochim. Biophys. Acta 262: 568.
Saffhill, R., Cooper, H. K., And Itzhaki, R. F., 1974, Detection by Dna polymerase I of breaks produced in rat liver chromatin in vivo by alkylating agents, Nature (London) 248: 153.
Salmon, A. G., 1976, Cytochrome P450 and the metabolism of vinyl chloride, Cancer Lett. 2: 109.
Sarasin, A. R., And Hanawalt, P. C., 1978, Carcinogens enhance survival of UV-irradiated simian virus 40 in treated monkey kidney cells: Induction of a recovery pathway, Proc. Natl. Acad. Sci. Usa 75: 346.
Sarasin, A. R., Goze, A., Devoret, R., And Moule, Y., 1977, Induced reactivation of UV-damaged phage A in E. coli K12 host cells treated with aflatoxin B1 metabolites, Mutat. Res. 42: 205.
Sarma, D. S. R., 1973, Chemical interaction measurements, in: Carcinogenesis Testing of Chemicals ( L. Golberg, ed.), p. 95, Crc Press, Cleveland.
Sarma, D. S. R., Zubroff, J., Michael, R. O., And Rajalakshmi, S., 1974, Dna damage and repair in vivo—A measurement of in vivo carcinogen–Dna interaction and a possible bioassay for carcinogens, Excerpta Med. Int. Congr. Ser. 350: 82.
Sarma, D. S. R., Rajalakshmi, S., And Farber, E., 1975, Chemical carcinogenesis: Interactions of carcinogens with nucleic acids, in: Cancer: A Comprehensive Treatise, Vol. 1 ( F. F. Becker, ed.), p. 235, Plenum Press, New York.
Sarma, D. S. R., Zubroff, J., And Rajalakshmi, S., 1977, Repair in vivo of liver deoxyribonucleic acid damaged by hycanthone and related compounds, Mol. Pharmacol. 13: 719.
Sarma, D. S. R., Rajalakshmi, S., Udupa, R., Farber, E., And Rao, P. M., 1978, Factors influencing Dna damage and its repair with cellular implications for toxicology, in: Advances in Pharmacology and Therapeutics, Vol. 9 ( Y. Cohen, ed.), p. 71, Pergamon Press, Oxford.
Sasaki, M. S., And Tonomura, A., 1973, A high susceptibility of Fanconi’s anemia to chromosome breakage by Dna crosslinking agents, Cancer Res. 33: 1829.
Sasaki, T., And Yoshida, T., 1935, Production of carcinoma of the liver by feeding oaminoazotoluene, Arch. Pathol. Anat. 295: 175.
Scaife, J. J., 1970–1971, Aflatoxin B1: Cytotoxic mode of action evaluated by mammalian cell cultures, Febs Lett. 12: 143.
Schabort, J. C., 1971, The differential interaction of aflatoxin B2 with deoxyribonucleic acids from different sources and with purines and purine nucleosides, Chem. Biol. Interact. 3: 371.
Schendel, P. F., And Robins, P. E., 1978, Repair of 06-methylguanine in adapted Escherichia coli, Proc. Natl. Acad. Sci. Usa 75: 6017.
Scherer, E., And Emmelot, P., 1977, Pre-cancerous transformation in rat liver by diethylnitrosamine in relation to the repair of alkylated site in Dna, Mutat. Res. 46: 153.
Schneider, W. C., And Kuff, E. L., 1965, The isolation and some properties of rat liver mitochondrial deoxyribonucleic acid, Proc. Natl. Acad. Sci Usa 54: 1650.
Schoental, R., 1973, The mechanisms of action of the carcinogenic nitroso and related compounds, Br. J. Cancer 28: 436.
Schulz, U., And Mccalla, D. R., 1969, Reactions of cysteine with N-methyl-N-nitroso-p-toluenesulfonamide and N-methyl-N’ -nitro-N-nitrosoguanidine, Can. J. Biochem. 47: 2021.
Schwartz, E. L., And Goodman, J. I., 1979, Quantitative and qualitative aspects of the binding of N-hydroxy-2-acetylaminofluorene to hepatic chromatin fractions, Chem. Biol. Interact. 26: 287.
Segal, A., Schroeder, M., Barnette, O., And Van Duuren, B. L., 1974, Studies on the effects in vitro of ß-propiolactone and ß-propiolact[14C]one on whole mouse skin chromatin, Biochem. Pharmacol. 23: 937.
Selkirk, J. K., Huberman, E., And Heidelberger, C., 1971, An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen dibenz(a, h)anthracene, Biochem. Biophys. Res. Commun. 43: 1010.
Setlow, R. B., And Regan, J. D., 1972, Defective repair of N-acetoxy-2-acetylaminofluorene-induced lesions in the Dna of xeroderma pigmentosum cells, Biochem. Biophys. Res. Commun. 46: 1019.
Shank, R. C., And Magee, P. N., 1967, Similarities between the biochemical actions of cycasin and dimethylnitrosamine, Biochem. J. 105: 521.
Shapiro, R., 1968, Chemistry of guanine and its biologically significant derivatives, Prog. Nucleic Acid Res. Mol. Biol. 8: 73.
Shapiro, R., 1969, Reactions with purines and pyrmidines, Ann. N.Y. Acad. Sci. 163: 624.
Shearman, C. W., And Loeb, L. A., 1979, Effects of depurination on the fidelity of Dna synthesis, J. Mol. Biol. 128: 197.
Shibata, T., Dasgupta, C. Cunningham, R. P., And Radding, C. M., 1979, Purified Escherichia coli rec-A-protein catalyzed homologous pairing of superhelical Dna and single stranded fragments, Proc. Natl. Acad. Sci. Usa 76: 1638.
Shinohara, K., And Cerutti, P. A., 1977, Excision repair of benzo(a)pyrene–deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts057BL/6J, Proc. Natl. Acad. Sci. Usa 74: 979.
Shooter, K. V., 1978, Dna phosphotriesters as indicators of cumulative carcinogen-induced damage, Nature (London) 274: 612.
Shooter, K. V., And Merrifield, K., 1976, An assay for phosphotriester formation in the reaction of alkylating agents with deoxyribonucleic acid in vitro and in vivo, Chem. Biol. Interact. 13: 223.
Shooter, K. V., House, R., Shah, S. A., And Lawley., P. D., 1974a, The molecular basis for biological interaction of nucleic acid: The action of methylating agents on the Rna containing bacterophage R-17, Biochem. J. 137: 303.
Shooter, K. V., House, R., And Merrifield, K., 1974b, Biological effects of phosphotriester formation, Biochem. J. 137: 313.
Shull, K. H., 1962, Hepatic phosphorylase and adenosine triphosphate levels in ethionine treated rats, J. Biol. Chem. 237: 1734.
Shull, K. H., Mcconomy, J., Vogt, M., Castillo, A., And Farber, E., 1966, On the mechanism of induction of hepatic adenosine triphosphate deficiency by ethionine, J. Biol. Chem. 241: 5060.
Silverman, B., And Mirsky, A. E., 1973, Accessibility of Dna in chromatin to Dna polymerase and Rna polymerase, Proc. Natl. Acad. Sci. Usa 70: 1326.
Sims, P., And Grover, P. L., 1968, Quantitative aspects of the metabolism of 7,12-dimethylbenz(a)anthracene by liver homogenates from animals of different age, sex and species, Biochem. Pharmacol. 17: 1751.
Singer, B., 1975, Chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis, Prog. Nucleic Acid Res. Mol. Biol. 15: 219.
Singer, B., 1979, N-Nitrosoalkylating agents: Formation and persistence of alkyl derivatives in mammalian nucleic acid as contributing factors in carcinogenesis, J. Natl. Cancer Inst. 62: 1329.
Singer, B., And Brent, T. P., 1981, Human lymphoblasts contain Dna glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not 06-alkylguanines, Proc. Natl. Acad. Sci. Usa 78: 856.
Singer, B., And Fraenkel-Conrat, H., 1969, Chemical modification of viral ribonucleic acid. Viii. The chemical and biological effects of methylating agents and nitrosoguanidine on tobacco mosaic virus, Biochemistry 8: 3266.
Slaga, T. J., Bracken, W. M., Viaje, A., Levin, W., Vagi, H., Jerina, D. M., And Conney, A. H., 1977, Comparison of the tumor-initiating activities of benzo(a)pyrene-arene-oxides and diolepoxides, Cancer Res. 37: 4130.
Smerdon, M. J., And Lieberman, M. W., 1978, Nucleosome re-arrangement in human chromatin during UV-induced Dna-repair synthesis, Proc. Natl. Acad. Sci. Usa 75: 4238.
Smerdon, M. J., Kastan, M. B., And Lieberman, M. W., 1979, Distribution of repair-incorporated nucleotides and nucleosome re-arrangement in the chromatin of normal and xeroderma pigmentosum human fibroblasts, Biochemistry 18: 3732.
Smith, G. J., Kaufman, D. G., And Grisham, J. W., 1980, Decreased excision of O6-methylguanine and N-7-methylguanine during the S-phase in 10T2 cells, Biochem. Biophys. Res. Commun. 92: 787.
Smith, J. D., And Dunn, D. B., 1959, The occurrence of methylated guanines in ribonucleic acids from several sources, Biochem. J. 72: 294.
Smith, R. C., And Salmon, W. D., 1965, Formation of S-adenosylethionine by ethionine-treated rats, Arch. Biochem. Biophys. 111: 191.
Smuckler, E. A., And Koplitz, M., 1969, The effects of carbon tetrachloride and ethionine on Rna synthesis in vivo and in isolated rat liver nuclei, Arch. Biochem. Biophys. 132: 62.
Smuckler, E. A., And Koplitz, M., 1976, Polyadenylic acid content and electrophoretic behavior of in vitro released Rna’s in chemical carcinogenesis, Cancer Res. 36: 881.
Snyder, A. L., Kann, H. E., JR., And Kohn, K. W., 1971, Inhibition of the processing of ribosomal precursor Rna by intercalating agents, J. Mol. Biol. 5: 555.
Sobell, H. M., Tsai, C. C., Jain, S. C., And Gilbert, S. G., 1977, Visualization of drug nucleic acid interactions at atomic resolution. Iii. Unifying structural concepts in understanding drug—Dna interactions and their broader implications in understanding protein—Dna interactions, J. Mol. Biol. 114: 333.
Solt, D. B., And Farber, E., 1976, A new principle for the sequential analysis of chemical carcinogenesis, including a quantitative assay for initiation in liver, Nature (London) 263: 701.
Sporn, M. B., Dingman, C. W., Phelps, H. L., And Wogan, G. N., 1966, Aflatoxin B1: Binding to Dna in vitro and alteration of Rna metabolism in vivo, Science 151: 1539.
Stacey, K. A., Coff, M., Cousens, S. F., And Alexander, P., 1957–1958, The reactions of the “radiomimetic” alkylating agents with macromolecules in vitro, Ann. N.Y. Acad. Sci. 68:682.
Stein, G., Stein, J., Kleinsmith, L., Park, W., Jansing, R., And Thomson, J., 1976, Non-histone chromosomal proteins and histone gene-transcription, Prog. Nucleic Acid Res. Mol. Biol. 19: 421.
Stekol, J. A., 1965, in: Transmethylation and Methionine Biosynthesis (S. K. Shapiro and F. Schiewk, eds.), p. 231, University of Chicago Press, Chicago.
Stekol, J. A., Mody, U., And Perry, J., 1960, The incorporation of the carbon of the ethyl group of ethionine into liver nucleic acids and the effect of ethionine feeding on the content of nucleic acids in rat liver, J. Biol. Chem. 235: 54.
Stewart, B. W., And Farber, E., 1973, Strand breakage in rat liver Dna and its repair following administration of cyclic nitrosamines, Cancer Res. 33: 3209.
Stewart, B. W., And Magee, P. N., 1972, Metabolism and some biochemical effects of Nnitrosómorpholine, Biochem. J. 126: 21 P.
Straub, K. M., Meehan, T., Burlingame, A. L., And Calvin, M., 1977, Identification of major adducts formed by reaction of benzo(a)pyrene diol epoxide with. Dna in vitro, Proc. Natl. Acad. Sci. Usa 74: 5285.
Stumpf, R., Margison, G. P., Montesano, R., And Pegg, A. E., 1979, Formation and loss of alkylated purines from Dna of hamster liver after administration of dimethylnitrosamine, Cancer Res. 39: 50.
Sudhakar, S., Tew, K. D., Schein, P. S., Woolley, P. V., And Smulson, M. E., 1979, Nitrosourea interaction with chomatin and effect on poly(adenosine diphosphate ribose) polymerase activity, Cancer Res. 39: 1411.
Sugimura, T., Okabe, K., And Nagao, M., 1966, The metabolism of 4-nitroquinoline-l-oxide, a carcinogen. Iii. An enzyme catalyzing the conversion of 4-nitroquinoline-1-oxide to 4hydroxyaminoquinoline-I-oxide in rat liver and hepatomas, Cancer Res. 26: 1717.
Sugiura, K., Teller, M. N., Parham, J. C., And Brown, G. B., 1970, A comparison of the oncogenicities of 3-hydroxyxanthine, guanine-3-N-oxide and some related compounds, Cancer Res. 30: 184.
Sunderman, F. W. JR., And Estahani, M., 1968, Nickel carbonyl inhibition of Rna polymerase activity in hepatic nuclei, Cancer Res. 28: 2565.
Svoboda, D., And Reddy, J., 1970, Invasive tumors induced in rats with actinomycin D., Cancer Res. 30: 2271.
Swain, C. G., And Scott, C. B., 1953, Quantitative correlation of relative rates. Comparison of hydroxide ion with other nucleophilic reagents toward alkyl halides, esters, epoxides and acyl halides, J. Am. Chem. Soc. 75: 141.
Swann, P. F., And Magee, P. N., 1968, Nitrosamine induced carcinogenesis: The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethylsulfate and methylmethanesulphonate, Biochem. J. 110: 39.
Swann, P. F., And Magee, P. N., 1971, The alkylation of N-7 of guanine of nucleic acids of the rat by dimethylnitrosamine, N-ethyl-nitrosourea and ethylmethanesulphonate, Biochem. J. 125: 841.
Swann, P. F., Pegg, A. E., Hawks, A., Farber, E., And Magee, P. N., 1971, Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine, Biochem. J. 123: 175.
Swenberg, J. A., Cooper, H. K., Buechler, J., And Kleihues, P., 1979, 1,2-Dimethylhydrazine induced methylation of Dna bases in various rat organs and the effect of pretreatment with disulfiram, Cancer Res. 39: 465.
Swenson, D. H., And Lawley, P. D., 1978, Alkylation of deoxyribonucleic acid by carcinogens dimethylsulphate, ethylmethanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: Relative reactivity of the phosphodiester site thymidylyl (3’-5’) thymidine, Biochem. J. 171: 575.
Swenson, D. H., Miller, J. A., And Miller, E. C., 1973, 2,3-Dihydro-2,3-dihydroxy-aflatoxin Bt: An acid hydrolysis product of an B1 adduct formed by hamster and rat liver microsomes in vitro, Biochem. Biophys. Res. Commun. 53:1260.
Szafarz, D., And Weisburger, J. H., 1969, Stability of binding of label from N-hydroxy-N-2fluorenylacetamide to intraceullar targets, particularly deoxyribonucleic acid in rat, Cancer Res. 29: 962.
Tada, M., And Tada, M., 1971, Interaction of a carcinogen, 4-nitroquinoline-1-oxide, with nucleic acids: Chemical degradation of the adducts, Chem. Biol. Interact. 3: 225.
Tada, M., And Tada, M., 1972, Enzymatic activation of the carcinogen 4-hydroxyaminoquinoline-1-oxide and its interaction with cellular macromolecules, Biochem. Biophys. Res. Commun. 46: 1025.
Tada, M., And Tada, M., 1976, Main binding sites of the carcinogen 4-nitroquinoline-1-oxide in nucleic acids, Biochim. Biophys. Acta 454: 558.
Tada, M., Tada, M., And Takahashi, T., 1967, Interaction of a carcinogen, 4-hydroxyaminoquinoline-l-oxide, with nucleic acids, Biochem. Biophys. Res. Commun. 29: 469.
Teebor, G. W., And Duker, N. J., 1975, Different ultraviolet Dna endonuclease activity in human cells, Nature (London) 255: 82.
Tew, K. D., Sudhakar, S., Schein, P. S., And Smulson, M. E., 1978, Binding of chlorozotocin and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea to chromatin and nucleosomal fraction of HeLa-cells, Cancer Res. 38: 3371.
Tew, K. D., Schein, P., Saslaw, L. D., And Smulson, M. E., 1979, Steroid chromatin interactions modify nuclear alkylation by nitrosoureas, Proc. Am. Assoc. Cancer Res. 20: 191.
Theiss, J. C., And Shimkin, M. B., 1978, Inhibiting effect of caffeine on spontaneous and urethan-induced lung tumors in strain A mice, Cancer Res. 38: 1757.
Tlsty, T. D., And Lieberman, M. W., 1978, The distribution of Dna repair synthesis in chromatin and its re-arrangement following damage with N-acetoxy-2-acetylaminofluorene, Nucleic Acids Res. 5: 3261.
Todaro, G. J., And Green, H., 1966, Cell growth and the initiation of transformation by SV40, Proc. Natl. Acad. Sci. Usa 55: 302.
ToulmÉ, F., Helene, C., Fuchs, R. P. P., And Daune, M., 1980, Binding of a tryptophan-containing peptide (lysyltryptophyllysine) to deoxy-ribonucleic acid modified by 2-(N-acetoxy acetylamino)fluorene, Biochemistry 19: 870.
Troll, W., Belman, S., Berkowitz, E., Chmielewicz, Z. F., Ambrus, J. L., And Bardos, T. J., 1968, Differential responses of Dna and Rna polymerase to modifications of the template rat liver Dna caused by action of the carcinogen acetylaminofluorene in vivo and in vitro, Biochim. Biophys. Acta 157: 16.
Trosko, J. E., Frank, P., Chu, E. H. Y., And Becker, J. E., 1973, Caffeine inhibition of postreplication repair of N-acetoxy-2-acetylaminofluorene damaged Dna in Chinese hamster cells, Cancer Res. 33: 2444.
Ts’o P. O. P., Lesko, S. A., And Umans, R. S., 1969, The physical binding and the chemical linkage of benzopyrene to nucleotides, nucleic acids and nucleohistones, in: Physico-chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 ( E. D. Bergmann and B. Pullman, eds.), p. 106, The Israel Academy of Science and Humanities, Jerusalem.
Tsuda, H., Sarma, D. S. R., Rajalakshmi. S., Zubroff, J., Farber, E., Batzinger, R. P., Nam Cha, Y., And Bueding, E., 1979, Induction of hepatic neoplastic lesions in mice with a single dose of hycanthone methanesulfonate after partial hepatectomy, Cancer Res. 39: 4491.
Uhlenhopp, E. L., And Krasna, A. I., 1971, Alterations in the structure of deoxyribonucleic acid on chemical methylation, Biochemistry 10: 3290.
Van Duuren, B. L., Goldschmidt, B. M., And Seltzman, H. H., 1968–1969, The interaction of mutagenic and carcinogenic agents with nucleic acids, Ann. N.Y. Acad. Sci. 153: 744.
Van Lancker, J. L., And Tomura, T., 1974, Purification and some properties of a mammalian repair endonuclease, Biochim. Biophys. Acta 353: 99.
Veleminsky, J., Osterman Golkar, S., And Ehrenberg, L., 1970, Reaction rates and biological action of N-methyl and N-ethylnitrosourea, Mutat. Res. 10: 169.
Venitt, S., Brookes, P., And Lawley, P. D., 1968, Effects of alkylating agents on the induced synthesis of ß-galactosidase by Escherichia coli B,_1, Biochim. Biophys. Acta 155: 521.
Verly, W. G., Gossard, F., And Caine, P., 1974, In vitro repair of apurinic sites in Dna, Proc. Natl. Acad. Sci. Usa 71: 2273.
Villani, G., Boiteux, S., And Radman, M., 1978, Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in vitro Dna synthesis on irradiated templates, Proc. Natl. Acad. Sci. Usa 75: 3037.
Villa-Trevino, S., Shull, K. H., And Farber, E., 1963, The role of adenosine triphosphate deficiéncy in ethionine-induced inhibition of protein synthesis, J. Biol. Chem. 238: 1757.
Villa-Trevino, S., Shull, K. H., And Farber, E., 1966, The inhibition of liver ribonucleic acid synthesis by ethionine, J. Biol. Chem. 241: 4670.
Wagner, L., And Drews, J., 1970, The effect of aflatoxin B1 on Rna synthesis and breakdown in normal and regenerating rat liver, Eur. J. Cancer 6: 465.
Wagner, T. A., 1971, Physical studies on the interaction of lysergic acid diethylamide and trypanocidal dyes with Dna and Dna-containing genetic material, in: Progress in Molecular and Subceulluar Biology, Vol. 2 ( F. E. Hahn, ed.) p. 152, Springer-Verlag, New York.
Walker, I. G., And Ewart, D. F., 1973, The nature of single-strand breaks in Dna following treatment of L-cells with methylating agents, Mutat. Res. 19: 331.
Walker, M. S., Becker, F. F., And Rodriguez, L. V., 1979, In vivo binding of N-2-acetylaminofluorene and its N-hydroxy-derivative to the Dna of fractionated rat liver chromatin, Chem. BioL Interact. 27: 177.
Walpole, A. L., Roberts, D. C., Rose, F. L., Hendry, J. A., And Homes, R. F., 1954, Cytotoxic agents. IV. The carcinogenic actions of some monofunctional ethyleneimine derivatives, Br. J. Pharmacol. Chemother. 9: 306.
Wang, A. H. J., Quigley, G. J., Kolpak, F., Crawford, J. L., Van-Boom, J. H., Vander Marcel, G. And Rich, A., 1979, Molecular structure of a left handed double helical Dna fragment at atomic resolution, Nature (London) 282: 680.
Wang, T. Y., Kostraba, N. C., And Newman, R. S., 1976, Selective transcription of Dna mediated by non-histone proteins, Prog. Nucleic Acid Res. Mol. BioL 19: 447.
Warwick, G. P., 1967, The covalent binding of metabolites of tritiated 2-methyl-4-dimethylaminoazobenzene to rat liver nucleic acids and proteins and the carcinogenicity of the unlabelled compound in partially hepatectomised rats, Eur. J. Cancer 3: 227.
Warwick, G. P., 1969, The covalent binding of metabolites of 4-dimethylaminoazobenzene to liver nucleic acids in vivo. The possible role of cell proliferation in cancer initiation, in: Physico-chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 ( E. D. Bergmann and B. Pullman, eds.), p. 218, The Israel Academy of Science and Humanities, Jerusalem.
Warwick, G. P., And Roberts, J. J., 1967, Persistent binding of butter yellow metabolites to rat liver Dna, Nature (London) 213: 1206.
Weeks, C. E., Allaber, W. T., Louie, S. C., Lazear, E. J., And King, C. M., 1978, Role of aryl-hydroxamic acid acyltransferase in the mutagenicity of N-hydroxy-N-2-fluorenylacetamide in Salmonella typhimurium, Cancer Res. 38: 613.
Weinstein, I. B., 1970, Modifications in transfer Rna during chemical carcinogenesis, in: Genetic Concepts and Neoplasia, p. 380, Williams and Wilkins, Baltimore.
Weinstein, I. B., And Hirschberg, E., 1971, Mode of action of miracil D, in: Progress in Molecular and Subcellular Biology, Vol. 2 ( F. E. Hahn, ed.), p. 232, Springer-Verlag, New York.
Weinstein, L. B., Grunberger, D., Fujimura, S., And Fink, L. M., 1971, Chemical carcinogens and Rna, Cancer Res. 31: 651.
Weintraub, H., And Groudine, M., 1976, Transcriptionally active and inactive conformation of chromosomal subunits, Science 193: 848.
Weisburger, J. H., And Weisburger, E. K., 1973, Biochemical formation and pharmacological, toxicological and pathological properties of hydroxylamines and hydroxamic acids, Pharmacol. Rev. 25: 1.
Weisburger, J. H., Yamamoto, R. S., Williams, G. M., Grantham, P. H., Matsushima, T., And Weisburger, E. K., 1972, On the sulphate ester of N-hydroxy-N-2-fluorenylacetamide as a key ultimate hepatocarcinogen in the rat, Cancer Res. 32: 491.
Wells, R. D., 1971, The binding of actinomycin D to Dna, in: Progress in Molecular and Subcellular Biology, Vol. 2 ( F. E. Hahn, ed.), p. 21, Springer-Verlag, New York.
Wells, R. D., And Larson, J. E., 1970, Studies on the binding of actinomycin-D to Dna and Dna model polymers, J. Mol. BioL 49: 319.
Westra, J. G., Kriek, E., And Hitten Housen, H., 1976, Identification of the persistently bound carcinogen N-acetyl-2-aminofluorene to rat liver Dna in vivo, Chem. BioL Interact. 15: 149.
Wiebel, F. J., Matthews, E. G., And Gelboin, H. V., 1972, Ribonucleic acid synthesis-dependent induction of aryl hydrocarbon hydroxylase in the absence of ribosomal ribonucleic acid synthesis and transfer, J. Biol. Chem. 242: 4711.
Wilk, W., And Girke, W., 1969, Radical action of carcinogenesis alternant hydrocarbons, amines, and azo-dyes and their reactions with nucleobases, in: Physico-Chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. 1 ( E. D. Bergmann and B. Pullman, eds.), p. 91, The Israel Academy of Science and Humanities, Jerusalem.
Wilkins, R. J., And Hart, R. W., 1974, Preferential Dna repair in human cells, Nature (London) 247: 35.
Wilkinson, R., Hawks, A., And Pegg, A. E., 1975, Methylation of rat liver mitochondrial deoxyribonucleic acid by chemical carcinogens and associated alterations in physical properties, Chem. Biol. Interact. 10: 157.
Williams, J. I., And Friedberg, E. C., 1979, Deoxyribonucleic acid excision repair in chromatin after ultraviolet irradiation of human fibroblasts in culture, Biochemistry 18: 3965.
Williams, K., And Nerv, R., 1971, Aspects of the mechanism of urethane carcinogenesis, Xenobiotica 1: 545.
Wislocki, P. G., Borchert, P., Miller, E. C., And Miller, J. A., 1973, Further studies on the metabolism and carcinogenicity of safrole, Proc. Am. Assoc. Cancer Res. 14: 19.
Witkin, E. M., 1976, Ultraviolet mutagenesis and inducible Dna repair in Escherichia coli, Bacteriol. Rev. 40: 869.
WU, Y. S., And Smuckler, E. A., 1971, The acute effect of aminoazobenzene and some of its derivatives on Rna polymerase activity in isolated rat liver nuclei, Cancer Res. 31: 239.
Wunderlich, V., SchÜTT, M., BÖTtger, M., And Graffi, A., 1970, Preferential alkylation of mitochondrial deoxyribonucleic acid by N-methyl-N-nitrosourea, Biochem. J. 118: 99.
Wunderlich, V., Tezlaff, I., And Graffi, A., 1971–1972, Studies on nitrosodimethylanamine: Preferential methylation of mitochondrial Dna in rats and hamsters, Chem. Biol. Interact. 4: 81.
Yamasaki, H., Leffler, S., And Weinstein, I. B., 1977a, Effects of N-2-acetylaminofluorene modification on the structure and template activity of Dna and reconstituted chromatin, Cancer Res. 37: 684.
Yamasaki, H., Pulkrabek, P. G., Grunburger, D., And Weinstein, I. B., 1977, Differential excision from Dna of the C-8 and N2-guanosine adducts of N-acetyl-2-aminofluorene by single strand specific endonucleases, Cancer Res. 37: 3756.
Yamasaki, H., Roush, T. W., And Weinstein, I. B., 1978, Benzo(a)pyrene-7,8-dihydrodiol-9,10oxide modification of Dna: Relation to chromatin structure and reconstitution, Chem. Biol. Interact. 23: 201.
Yamaura, I., Marquardt, H., And Cavalieri, L. F., 1978, Effects of benzo(a)pyrene adducts on Dna synthesis in vitro, Chem. Biol. Interact. 23: 399.
Yang, J. T., And Samejima, T., 1969, Optical rotatory dispersion and circular dichroism of nucleic acids, Prog. Nucleic Acid Res. Mol. Biol. 9: 224.
Ying, T. S., 1980, Studies on acute cell injury, cell replication and Dna repair during the initiation of liver carcinogenesis, Ph.D. thesis, University of Toronto.
Ying, T. S., And Sarma, D. S. R., 1979, Role of liver cell necrosis in the induction of preneoplastic lesions, Proc. Am. Assoc. Cancer Res. 20: 14.
Ying, T. S., Sarma, D. S. R., And Farber, E., 1979, Induction of presumptive preneoplastic lesions in rat liver by a single dose of 1,2-dimethylhydrazine, Chem. Biol. Interact. 28: 363.
Yoshida, M., And Holoubek, V., 1976, Early effects of carcinogenic amino dyes on the protein patterns and metabolism in rat liver, Int. J. Biochem. 7: 259.
Younger, L. R., Salomon, R., Wilson, R. W., Peacock, A. C., And Gelboin, H. V., 1972, Effects of polycyclic hydrocarbons on ribonucleic acid synthesis in rat liver nuclei and hamster embryo cells, Mol. Pharmacol. 8: 452.
Youvan, D. C., And Hearst, J. E., 1979, Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal Rna, Proc. Natl. Acad. Sci. Usa 76: 3751.
Yuspa, S. H., And Bates, R. R., 1970, The binding of benzo(a)anthracene to replicating and non-replicating Dna in cell culture, Proc. Soc. Exp. Biol. Med. 135: 732.
Zahner, A. J., 1976, Possible role of Dna replication in chemical carcinogenesis: An investigation of the in vivo replication of rat liver Dna arylated by the hepatocarcinogen N-hydroxy-2acetylaminofluorene, Ph.D. thesis, Temple University.
Zahner, A. J., Rajalakshmi, S., And Sarma, D. S. R., 1977, Isolation of in vivo replicated rat liver Dna containing N-OH-2-Aaf metabolites(s), Proc. Am. Assoc. Cancer Res. 18: 99.
Zajdela, F., And Latarjet, R., 1973, Effect inhibiteur de la cafeine sur l’induction de cancers cutanes par les rayons ultraviolets chez la souris, C. R. Acad. Sci. Ser. D 277: 1073.
Zedek, M. S., Steinberg, S. S., Poynter, R. N., And Mcgowan, J., 1970, Biochemical and pathological effects of methylazoxymethanolacetate, a potent carcinogen, Cancer Res. 30: 801.
Zeiger, R. S., Salomon, R., Kinoshita, N., And Peacock, A. C., 1972, The binding of 9,10-dimethyl1,2-benzanthracene to mouse epidermal satellite Dna in vivo, Cancer Res. 32: 643.
Zieve, F. J., 1972, Inhibition of rat liver ribonucleic acid polymerase by the carcinogen N-hydroxy-2fluorenylacetamide, J. Biol. Chem. 247: 5987.
Zieve, F. J., 1973, Effects of the carcinogen N-acetoxy-2-fluorenylacetamide on the template properties of deoxyribonucleic acid, Mol. Pharmacol. 9: 658.
Zimmer, C., 1975, Effect of antibiotics netropsin and distamycin A on the structure and function of nucleic acids, Frog. Nucleic Acid Res. Mol. Biol. 15: 285.
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Rajalakshmi, S., Rao, P.M., Sarma, D.S.R. (1982). Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids. In: Becker, F.F. (eds) Etiology: Chemical and Physical Carcinogenesis. Cancer, A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6598-7_10
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