Clinical Trials using Monoclonal Antibodies

  • John W. Smith
  • Dan L. Longo


Early attempts at passive immunotherapy by administering natural antisera derived from recovered cancer patients to patients with active disease failed to result in significant antitumor responses. Many of the limitations of this serotherapy were remedied by the revolutionary innovation described by Kohler and Milstein (1) of monoclonal antibody production by means of hybridoma technology. Large quantities of homogeneous, highly specific antibody to a defined antigenic determinant became available for clinical trials. Most monoclonal antibodies (mAbs) used to date to treat cancer patients have been murine mAbs. Recently, clinical grade human mAbs have been generated in sufficient quantity to permit investigation.


Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Murine Monoclonal Antibody Antigenic Modulation Common Acute Lymphoblastic Leukemia Antigen 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • John W. Smith
    • 1
  • Dan L. Longo
    • 1
  1. 1.Biological Response Modifiers Program, Division of Cancer TreatmentNational Cancer InstituteFrederickUSA

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