Comparison of Therapeutic Potential of Cytokines

  • James E. Talmadge
  • Paul L. Black


Biological response modifiers (BRMs) are those agents or approaches that influence the relationship between the tumor and host by modifying the hosts response to tumor cells, with resultant therapeutic activity (9). A series of studies with recombinant cytokines designed to better understand their immunomodulatory and therapeutic properties have been undertaken. The present report discusses recombinant murine interferon-gamma (rM IFN-g), recombinant human tumor necrosis factor (rH TNF), rH interleukin-2 (rH IL-2), and rM colony stimulating factor-gm (rM CSF-gm). We discuss the development of Optimal Therapeutic Protocols (OTP) for preclinical studies and initial clinical trials that have been initiated to test the resultant clinical hypotheses.


Maximum Tolerate Dose Therapeutic Activity Hairy Cell Leukemia Biological Response Modifier Effector Cell Activity 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • James E. Talmadge
    • 1
  • Paul L. Black
    • 1
  1. 1.National Cancer Institute-Frederick Cancer Research FacilityPreclinical Screening Laboratory, Program Resources, Inc.FrederickUSA

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