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Evaluation of Immunomodulatory and Therapeutic Properties of Biological Response Modifiers: A Comparison of Preclinical and Clinical Studies

  • James E. Talmadge
  • Carl Pinsky
  • Ronald B. Herberman
  • Cedric Long
  • Paul L. Black

Abstract

Biological response modifiers (BRMs) are those agents or approaches that modify the relationship between the tumor and host by modifying the host’s biological response to the tumor cells with resultant therapeutic effects (1). BRMs may modify the host responses in several ways:
  1. 1.

    increase the host’s antitumor responses through augmentation and/or restoration of effector mechanisms or mediators of the host’s reaction which may be deleterious;

     
  2. 2.

    increase the host’s defenses by the administration of natural biologicals (or the synthetic-recombinant derivatives thereof) as effectors or mediators of an antitumor response;

     
  3. 3.

    augment the sensitivity of the host’s tumor cells to endogenous mechanisms for the control of tumor growth;

     
  4. 4.

    alter the transformed phenotype by increasing the differentiation/maturation of tumor cells;

     
  5. 5.

    increase the ability of the host to tolerate damage by cytotoxic modalities of cancer treatment.

     

Keywords

Effector Cell Maximum Tolerate Dose Acute Myelogenous Leukemia Therapeutic Activity Tumor Infiltrate Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • James E. Talmadge
    • 1
  • Carl Pinsky
    • 2
  • Ronald B. Herberman
    • 3
  • Cedric Long
    • 4
  • Paul L. Black
    • 1
  1. 1.Preclinical Screening LaboratoryNCI-Frederick Cancer Research Facility, Program Resources, Inc.FrederickUSA
  2. 2.Office of the Associate Director, Biological Response Modifiers Program, DCTNCI-Frederick Cancer Research FacilityFrederickUSA
  3. 3.Pittsburgh Cancer InstitutePittsburghUSA
  4. 4.Office of the DirectorNCI-Frederick Cancer Research FacilityFrederickUSA

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