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Inhibition of Mutagenesis and Carcinogenesis by N-Acetylcysteine

  • Silvio De Flora
  • Carlo Bennicelli
  • Anna Camoirano
  • Domizio Serra
  • Cristina Basso
  • Patrizia Zanacchi
  • Carmelo F. Cesarone

Abstract

N-acetylcysteine (NAC), a precursor of intracellular cysteine and glutathione (GSH)) (1), is extensively used in the treatment of patients suffering from respiratory diseases. Moreover, this synthetic aminothiol has been shown to possess a variety of antitoxic properties in humans, animals and in vitro test systems (2).

Keywords

Rani Tidine Strain TA100 Cigarette Smoke Condensate Diethyl Maleate Sodium Dichromate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P. Moldéus, I. A. Cotgreave, and M. Berggren, Lung protection by a thiol-containing antioxidant: N-acetylcysteine, Respiration 50, 31–42 (1986).PubMedGoogle Scholar
  2. 2.
    F. M. Muggia, et al., N-acetylcysteune (NAC): a significant chemoprotective adjunct. Seminars in Oncology 10., 1–92 (1983).PubMedGoogle Scholar
  3. 3.
    D. M. Maron and B. N. Ames, Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113, 173–215 (1983).PubMedGoogle Scholar
  4. 4.
    S. De Flora, P. Zanacchi, A. Camoirano, C. Bennicelli, and G. Badolati, Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test. Mutat. Res. 133, 161–198 (1984).PubMedGoogle Scholar
  5. 5.
    D. E. Levin, M. Hollstein, M. F. Christman, E. A. Schwiers, and B. N. Ames, A new Salmonella tester strain (TA102) with A-T base pairs at the site of mutation detects oxidative mutagens. Proc. Natl. Acad. Sci. USA 79, 7445–7449 (1982).PubMedCrossRefGoogle Scholar
  6. 6.
    H. Joenje, Introduction: oxygen metabolism, DNA repair, and the origin of spontaneous genetic instability. In Antimutagenesis and Anticarcinogenesis Mechanisms, 1986 (D. M. Shankel, P. E. Hartman, T. Kada and A. Hollaender, Eds.) pp. 339–341. Plenum Press, New York and London.Google Scholar
  7. 7.
    S. De Flora, C. Bennicelli, P. Zanacchi, A. Camoirano, A. Morelli, and A. De Flora, In vitro effects of N-acetylcysteine on the mutagenicity of direct-acting compounds and procarcinogens. Carcinogenesis 5, 505–510 (1984).PubMedCrossRefGoogle Scholar
  8. 8.
    M. Wilpart, P. Mainguet, D. Geeroms, and M. Roberfroid, Desmutagenic effects of N-acetylcysteine on direct and indirect mutagens. Mutat. Res. 142, 169–177 (1985).PubMedCrossRefGoogle Scholar
  9. 9.
    S. De Flora, et al., manuscripts in preparation.Google Scholar
  10. 10.
    S. De Flora, C. Bennicelli, D. Serra, A. Izzotti, and C. F. Cesarone, Role of glutathione and N-acetylcysteine as inhibitors of mutagenesis and carcinogenesis. In Absorption and Utilization of Amino Acids (M. Friedman, Ed.). CRC Press, Inc., Boca Raton, FL (in press).Google Scholar
  11. 11.
    S. De Flora, Detoxification of genotoxic compounds as a threshold mechanism limiting their carcinogenicity. Toxicol. Pathol. 12, 337–343 (1984).PubMedCrossRefGoogle Scholar
  12. 12.
    S. De Flora, C. Bennicelli, A. Camoirano, and P. Zanacchi, Genotoxicity of nitrosated ranitidine. Carcinogenesis 4, 255–260 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    S. De Flora, A. Camoirano, C. Basso, M. Astengo, P. Zanacchi, and C. Bennicelli, Bacterial genotoxicity of nitrosated famotidine. Mutagenesis 1, 125–130 (1986).PubMedCrossRefGoogle Scholar
  14. 14.
    S. De Flora, C. Bennicelli, A. Camoirano, D. Serra, M. Romano, G. A. Rossi, A. Morelli, and A. De Flora, In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis 6, 1735–1745 (1985).PubMedCrossRefGoogle Scholar
  15. 15.
    S. De Flora, M. Romano, C. Basso, M. Bagnasco, C. F. Cesarone, G. A. Rossi, and A. Morelli, Modulation of detoxifying activities in alveolar macrophages of rats treated with acetylcysteine, diethyl maleate and/or Aroclor. Anticancer Res. 6, 1009–1012 (1986).PubMedGoogle Scholar
  16. 16.
    S. De Flora, M. Astengo, D. Serra, and C. Bennicelli, Inhibition of urethan-induced lung tumors in mice by dietary N-acetyl-cysteine. Cancer Lett. 32, 235–241 (1986).PubMedCrossRefGoogle Scholar
  17. 17.
    C. F. Cesarone, L. Scarabelli, M. Orunesu, M. Bagnasco, A. Izzotti, and S. De Flora, Protective effects of thiols on carcinogenesis induced in rats by 2-acetylaminof luorene. This volume.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Silvio De Flora
    • 1
  • Carlo Bennicelli
    • 1
  • Anna Camoirano
    • 1
  • Domizio Serra
    • 1
  • Cristina Basso
    • 1
  • Patrizia Zanacchi
    • 1
  • Carmelo F. Cesarone
    • 2
  1. 1.Institute of HygieneUniversity of GenoaGenoaItaly
  2. 2.Institute of General PhysiologyUniversity of GenoaGenoaItaly

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