Toxicity and Radioprotective Efficacy of Bis (3,5-Diisopropylsalicylato) Copper II and CuCl2

  • Linda K. Steel
  • Sarath Seneviratne
  • William E. JacksonIII


Bis (3, 5-diisopropylsalicylato) copper II (CuDIPs), a low molecular weight lipid-soluble complex, has been suggested to be an effective, nontoxic radioprotectant in mice exposed to gamma radiation from a 60Co source (1). CuDIPs has also been shown to have antiinflammatory activity (2) and to catalyze the disproportionation of superoxide (3). In view of these observations, the present study examined the toxicity and radioprotective efficacy of CuDIPs, as well as those of diisopropylsalicylate (DIPs) and CuCl2, in both male and female B6D2F1 mice.


Gamma Radiation 60Co Source Proximal Tubular Epithelial Cell Dose Modify Factor Severe Kidney Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J.R.J. Sorenson, Bis (3,5-diisopropylsalicytate) copper (II), a potent radioprotectant with superoxide dismutase mimetic activity. J. Med. Chem. 27: 1747–1749 (1984).PubMedCrossRefGoogle Scholar
  2. 2.
    J.R.J. Sorenson, The anti-inflammatory activities of copper complexes. In: Metal Ions in Biological Systems (H. Siegel, Ed.), Vol. 14, pp. 77–124. Marcel Dekker, New York, 1982.Google Scholar
  3. 3.
    U. Weser, C. Richter, A. Wendel, and M. Younes, Reactivity of antiinflammatory and superoxide dismutase active Cu(II)-salicylates. Bioinorg. Chem. 8: 201–213 (1978).PubMedCrossRefGoogle Scholar
  4. 4.
    D.J. Finney, Probit Analysis, 3rd ed., pp. 1–99. Cambridge University Press, Cambridge, England, 1971.Google Scholar
  5. 5.
    D.J. Finney, Statistical Methods in Biological Assay, 3rd ed., pp. 370–379. MacMillan Publishing Company, Inc., New York, 1978.Google Scholar
  6. 6.
    G.W. Snedecor and W.G. Cochran, Statistical Methods, 7th ed., pp. 124–125. Iowa State University Press, Ames, Iowa, 1980.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Linda K. Steel
    • 1
  • Sarath Seneviratne
    • 1
  • William E. JacksonIII
    • 2
  1. 1.Radiation Biochemistry DepartmentArmed Forces Radiobiology Research InstituteBethesdaUSA
  2. 2.Computer and Electronics DepartmentArmed Forces Radiobiology Research InstituteBethesdaUSA

Personalised recommendations