Possible Mechanisms of Action of the Anticarcinogenic Protease Inhibitors

  • Jonathan Yavelow
  • Judith H. Kraft
  • Lorraine Schepis


Protease inhibitors have been shown to possess anticarcinogenic properties. Two synthetic protease inhibitors, tosyl phenylethyl chloro-methyl ketone (TPCK) and tosylarginine methylester (a competitive trypsin substrate), have been demonstrated to block the formation of skin tumors promoted with TPA in mice (1). These studies were repeated using the actinomycete-derived protease inhibitor leupeptin (2), thus establishing an in vivo basis for the involvement of proteases in the mechanism of carcinogenesis.


Detergent Extraction Crude Membrane Fraction Discontinuous Sucrose Density Gradient Synthetic Protease Inhibitor Tyrosine Ethyl Ester 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Jonathan Yavelow
    • 1
  • Judith H. Kraft
    • 1
  • Lorraine Schepis
    • 1
  1. 1.Department of BiologyRider CollegeLawrencevilleUSA

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