Abstract
Ozone (O3), a reactive species of oxygen, is an important natural constituent of the atmosphere (1). Background levels of ozone in the lower atmosphere may range up to 0.1 ppm and are modified by geographic elevation, solar radiation and climatic conditions (2). Since some ozone effects are radiomlmetic its actions may be enhanced in the presence of ionizing radiation from background and/or man-made sources (3,4).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R.D. Caddie and E.R. Allen, Atmospheric photochemistry. Science 167;243–249 (1970).
National Research Council, Committee on Medical and Biologic Effects of Environmental Pollutants, subcommittee on ozone and other photochemical oxidants. Toxicology, Ozone and other photochemical oxidants. N.A.S.-N.R.C. Publ. 19;323–387 (1977).
C. Borek and M.A. Mehlman, Evaluation of health effects toxicity and biochemical mechanisms of ozone. In: The biomedical effects of ozone and related photochemical oxidants (S.D. Lee, et al., Eds.) pp. 325–361. Princeton Scientific Publishers, Inc., Princeton, N.J., 1983.
C. Borek, M. Zaider, A. Ong, H. Mason, and G. Witz, Ozone acts directly and synergistically with ionizing radiation to induce in vitro neoplastic transformation. Carcinogenesis 7;1611–1613 (1986).
Reed, S. Glaser, and J. Kaldor, Ozone toxicity symptoms among flight attendants. Am. J. Ind. Med. 1;43–54 (1980).
W. A. Pryor, M.M. Dooley, and D.F. Church, Mechanisms for the reaction of ozone with biological molecules, the source of the toxic effects of ozone. In: Advances in Modern Toxicology. The biological effects of ozone and photochemical oxidants. (S.J. Lee et al., Eds.) pp. 7–19. Princeton Scientific Publishers, Inc., Princeton, N.J., 1983.
M.A. Mehlman and C. Borek, Toxicity and biochemical mechanisms of ozone. Environ. Res. 42:36–53 (1987).
D.A. Johnson, Ozone inactivation of human alpha 1-proteinase inhibitor. Am. Rev. Respir. Dls. 121:1031–1038 (1980).
C.K. Chow and A.L. Tappel, An enzjnnatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. Lipids 7:518–524 (1972).
A.J. DeLucia, P.M. Hogue, M.G. Mustafa, and E.G. Cross, Ozone interaction with rodent lung, effect on sulfhydryls and sulfhydryl-containing enzyme activities. J. Lab. Clin. Med. 80:559–566 (1972).
M.G. Mustafa and S.D. Lee, Pulmonary biochemical alterations resulting from ozone exposure. Ann. Occup. Hyg. 19:17–26 (1976).
G. Witz, N.J. Lawrie, A. Zaccaria, H.E. Ferran Jr., and B.D. Goldstein, The reaction of 2-thiobarbituric acid with biologically active alpha, beta-unsaturated aldehydes. J. Free Radicals Biol. Med. 2:33–39 (1986).
W.A. Pryor, J.P. Stanley, and E. Blair, Autooxidation of polyunsaturated fatty acids: II. A suggested mechanism for the formation of TBA-reactive materials from prostaglandin-like endoperoxides. Upids 2:370–379 (1976).
C. Borek, C.M. Fenoglio, and D.W. King, (Eds.) Membranes, Cancer and Aging, Advances in Pathobiology, Vol. 7. Thieme-Stratton, Inc., New York, 1980.
C. K. Chow, Influence of dietary vitamin E on susceptibility to ozone exposure. In: The Biochemical Effects of Ozone and Photochemical Oxidants (S.D. Lee, M.G. Mustafa and M.A. Mehlman, Eds.) pp. 75–93. Princeton Scientific Publishers, Inc., Princeton, N.J., 1983.
B. L. Fletcher and A.L. Tappel, Protective effects of dietary alpha-tocopherol in rats exposed to toxic levels of ozone and nitrogen dioxide. Environ. Res. 6:165–175 (1973).
C. Borek, A. Ong, H. Mason, L. Donahue, and J.E. Biaglow, Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms of action. Proc. Natl. Acad. Sci. U.S.A. 83:1490–1494 (1986).
C. Borek and W. Troll, Modifiers of free radicals in inhibit in vitro the oncogenic actions of x-rays, bleomycin and the tumor promoter 12-0-tetradecanoylphorbol-13-acetate. Proc. Natl. Acad. Sci. U.S.A. 80:1304–1307 (1983).
R. Zimmerman and P.A. Cerutti, Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T-1/2/C18 fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 81:2085–2087 (1984).
T.J. Slaga, A.J.P. Klein-Szanto, L.L. Triplett, L.P. Yotti, and J. E. Trosko, Skin tumor promoting activity of benzoylperoxide, a widely used free radical generating compound. Science 213:1023–1025 (1981).
B.N. Ames, Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221:1256–1263 (1983).
C. Borek, Radiation oncogenesis in culture. Adv. Cancer Res. 159–232 (1982).
O.F. Nygaard and M.G. Simic (Eds.) Radioprotectors and Anticarcinogens, Academic Press, New York, 1983.
C. Borek, Radiation and chemically induced transformation: Free radicals, antioxidants and cancer. Br. J. Cancer, (in press, 1987).
L.W. Wattenberg, Inhibiting chemical carcinogens by minor dietary factors. In: Molecular Interrelations of Nutrition and Cancer (M.S. Arnot, et al., Eds.) pp. 43–56 Raven Press, New York, 1982.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Borek, C., Ong, A., Mason, H., Zaider, M., Witz, G., Mehlman, M.A. (1987). Ozone Carcinogenesis and Co-Carcinogenesis and its Prevention. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_38
Download citation
DOI: https://doi.org/10.1007/978-1-4615-6462-1_38
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-6464-5
Online ISBN: 978-1-4615-6462-1
eBook Packages: Springer Book Archive