Oncogenes and Malignant Transformation of Human Keratinocytes

  • Norbert E. Fusenig
  • Petra Boukamp
  • Dirk Breitkreutz
  • Siegfried Karjetta
  • Rule T. Petrusevska


Activated oncogenes, particularly of the ras gene family, have been detected in a variety of solid human tumors and interpreted as causal agents in the development of neoplasia (1, 2). Immortalized and aneuploid mesenchymal cells from the rodent NTH 3T3 cell line could be rendered tumorigenic by transfection oncogenes (3–5) while normal fibroblasts required two cooperating oncogenes or additional enhancers (6–9). So far, it has not been possible to malignantly transform human fibroblasts with oncogenes in vitro (10, 11).


HaCaT Cell Human Epithelial Cell Human Epidermal Keratinocytes HaCaT Cell Line Cellular Oncogene 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Norbert E. Fusenig
    • 1
  • Petra Boukamp
    • 1
  • Dirk Breitkreutz
    • 1
  • Siegfried Karjetta
    • 1
  • Rule T. Petrusevska
    • 1
  1. 1.Division of Differentiation and Carcinogenesis in vitro Institute of BiochemistryGerman Cancer Research CenterHeidelbergGermany

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