A Possible Role for Free Radicals in Tumor Progression
The possible role of free radicals during experimental chemical carcinogenesis has been recently reviewed and speculated on by several authors (1–4). Much of the direct evidence for free-radical participation in carcinogenesis has come from the mouse skin model system.
KeywordsFree Radical Free Radical Scavenger Benzoyl Peroxide Mouse Skin Calcium Ionophore A23187
Unable to display preview. Download preview PDF.
- 1.T.J. Slaga, V. Solanki and M. Logani, Studies on the mechanism of action of antitumor promoting agents: suggestive evidence for the involvement of free radicals in promotion. In: Radioprotectors and Anticarcinogenesis. (O.F. Nygaard and M.G. Simic, Eds.), pp. 471–485 Academic Press, New York, 1983.Google Scholar
- 8.W.J. Kozumbo, J.L. Seed and T.W. Kensler, Inhibition of 2(3)-tert-Butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 42: 2555–2559 (1983).Google Scholar
- 10.J.P. Perchellet, M.D. Owen, T.D. Posey, D.K Orten and B.A. Schneider, Inhibitory effects of glutathione level-raising agents and D-a-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetrade-canoylphorbol-13-acetate. Carcinogenesis 6: 567–573 (1985).PubMedCrossRefGoogle Scholar
- 11.J.P. Perchellet, N.L. Abney, R.M. Thomas, Y.L. Guislan and E.M. Perchellet, Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction and complete and multistage carcinogenesis in mouse skin. Cancer Res. 41: 477–485 (1987).Google Scholar
- 20.W.A. Pryor, The role of free radical reactions in biological systems. In: Free Radicals in Biology, Vol. 1 (W.A. Pryor, Ed.), pp. 1–49. Academic Press, New York, 1975.Google Scholar
- 21.B.G. Taffe, N. Takahashi, T.W. Kensler and R.P. Mason, Generation of free radicals from organic hydroperoxide tumor promoters by mouse epidermal cells. Pharmacologist 28:175 (1986).Google Scholar
- 23.J.F. O’Connell, A.J.P. Klein-Szanto, D.M. DiGiovanni, J.W. Fries and T.J. Slaga, Malignant progression of mouse skin papillomas treated with ethylnitrosourea, N-methyl-N1-nitrosoguanidine, or 12-O-tetradecanoylphorbol-13-acetate. 30:269–271 (1986).Google Scholar
- 24.J.F. O’Connell, A.J.P. Klein-Szanto, D.M. DiGiovanni, J.W. Fries and T.J. Slaga, Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res, 46: 2863–2865 (1985).Google Scholar
- 25.J.B. Rotstein, J.F. O’Connell and T.J. Slaga, The enhanced progression of papillomas to carcinomas by peroxides in the 2-stage mouse skin model. Proc. Am. Assoc. Cancer Res. 27:143 (1986) [Abstract].Google Scholar
- 28.A.J. Saladino, J.C. Willey, J.F. Lechner, R.C. Grafstrom, M. LaVeck and C.C. Harris, Effects of formaldehyde, acetaldehyde, benzoyl peroxide and hydrogen peroxide on cultured normal human bronchial epithelial cells. Cancer Res. 45: 2522–2526 (1986).Google Scholar
- 30.AJ.P. Klein-Szanto, K.G. Nelson, Y. Shah and T.J. Slaga, Simultaneous appearance of keratin modifications and yglutamyltransferase activity as indictors of tumor progression in mouse skin papillomas. J. Natl. Cancer Inst. 70: 161–168 (1986).Google Scholar