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UVB Prevention of Mouse Skin Tumor Induction by the Initiation-Promotion Protocol

  • H. L. Gensler

Abstract

Repeated exposure of mice to UVB (280 to 320 nm) radiation results in the development of a state of tumor-specific suppression that renders the host Incapable of mounting an effective immunological rejection response to antigenic determinants expressed by UV-induced skin tumor cells (1,2). In this system, normal mice can reject transplanted UV-induced tumor cells, whereas UV-treated mice cannot. The objective of this research was to determine if UVB irradiation influences mouse skin tumorigcnesis induced by an initiation-promotion protocol.

Keywords

Mouse Skin Distant Skin Promotion Regimen Mouse Skin Tumor Mouse Skin Tumorigenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • H. L. Gensler
    • 1
  1. 1.Department of Radiation Oncology and Cancer CenterUniversity of Arizona Health Sciences CenterTucsonUSA

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