UVB Prevention of Mouse Skin Tumor Induction by the Initiation-Promotion Protocol
Repeated exposure of mice to UVB (280 to 320 nm) radiation results in the development of a state of tumor-specific suppression that renders the host Incapable of mounting an effective immunological rejection response to antigenic determinants expressed by UV-induced skin tumor cells (1,2). In this system, normal mice can reject transplanted UV-induced tumor cells, whereas UV-treated mice cannot. The objective of this research was to determine if UVB irradiation influences mouse skin tumorigcnesis induced by an initiation-promotion protocol.
KeywordsMouse Skin Distant Skin Promotion Regimen Mouse Skin Tumor Mouse Skin Tumorigenesis
- 1.M.L. Kripke, The Immunology of skin cancer. In Immunology and Cancer, The University of Texas M.D. Anderson Symposium on Fundamental Cancer Research, Vol. 38, 1986 (M.L. Kripke and P. Frost, Eds.) pp. 113–120, University of Texas Press, Austin, Texas.Google Scholar
- 3.W.J. Conover, Practical Nonparametric Statistics, 1980, John Wiley and Sons, New York.Google Scholar
- 9.L.K. Roberts and R.A. Daynes, Modifications of the immunogenic properties of chemically induced tumors arising in hosts treated concomitantly with ultraviolet light. J. Immunol. 438–444 (1980).Google Scholar
- 11.A.W. Wood, R.L. Chang, M.T. Huang, E. Baggiolini, J.J. Partridge, M. Uskokovlc and A.H. Conney, Stimulatory effect of 1α,25-dihydroxjrvitamin D3 on the formation of skin tumors in mice treated chronically with 7,12-dimethylbenz[a]anthracene. Biochem. Biophys. Res. Comm. 130, 924–931 (1985).PubMedCrossRefGoogle Scholar