Mechanism of Action of Exonuclease III from Escherichia Coli

  • Yoke W. Kow
  • Hiroshi Ide
  • Susan S. Wallace


Reactive oxygen species such as hydrogen peroxide, superoxide radical, and hydroxyl radical are formed during aerobic respiration (1). These reactive oxygen species can react with vital cell components such as the cell membrane, protein, as well as DNA, potentially leading to mutagenesis and cell death (1). In Escherichia coli. repair endonucleases. such as exonuclease III (2, 4) and endonuclease IV (3) appear to be involved in the repair of oxidative damages in DNA. Further, endonuclease III was shown to recognize oxidative base damages (4).


Synthesize Heat Shock Protein Thymine Glycol Apurinic Site Glycosylic Linkage Oxidative Base Damage 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Yoke W. Kow
    • 1
  • Hiroshi Ide
    • 1
  • Susan S. Wallace
    • 1
  1. 1.Department of Microbiology and ImmunologyNew York Medical CollegeValhallaUSA

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