Advertisement

European Serotype PRRSV Vaccine Protects Against European Serotype Challenge Whereas an American Serotype Vaccine Does Not

  • P. A. M. van Woensel
  • K. Liefkens
  • S. Demaret
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 440)

Abstract

Pigs were either vaccinated with an American serotype Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine or with a European serotype vaccine. A control group of was left unvaccinated. At four weeks after vaccination the PRRSV-spe-cific antibody titres were determined and one third of each group was challenged with a Spanish, one third with a German and one third with a Dutch PRRSV wild type strain. The serological responses, measured at 4 weeks after vaccination, confirmed that both vaccines were of a different serotype. It was demonstrated that vaccination with an American serotype vaccine slightly reduced the amount of viraemia after challenge with European PRRSV wild type strains. Only after challenge with the Spanish PRRSV strain a moderate, and statistically significant, reduction in viraemia was observed. This is in contrast to vaccination with a European vaccine strain, where viraemia was completely suppressed after challenge with the German PRRSV isolate and almost completely suppressed after challenge with the Spanish and Dutch isolates.

Keywords

Respiratory Syndrome Virus Serotype Virus Reproduction Ratio Reporter Virus Serotype Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Becker N.g., 1989, Analysis of infectious disease data. Chapman and Hall Ltd, London, New York.Google Scholar
  2. Drew, T.W., Meulenberg, J.M., Sands, J., and Paton, D.J., 1995, Production, characterization and reactivity of monoclonal antibodies to porcine reproductive and respiratory syndrome virus, J. Gen. Virol. 76: 1361–1369.PubMedCrossRefGoogle Scholar
  3. Kapur, V., Elam, M.R., Pawlovich, T.M,. and Murtaugh, M.P., 1996, Genetic variation, in porcine reproductive and respiratory syndrome virus isolates, in The Midwestern United States, J. Gen. Virol. 77: 1271–1276.PubMedCrossRefGoogle Scholar
  4. Meng, X.-J., Paul, P.S., Halbur, P.G., and Lum, M.A., 1994, Phylogenetic analyses of the putative M (ORF 6) and N (ORF 7) genes of porcine reproductive and respiratory syndrome virus (PRRSV); implications for the existence of two genotypes of PRRSV in the U.S.A. and Europe, Arch. Virol. 140: 745–755.CrossRefGoogle Scholar
  5. Mardassi, H., Mounir, S., and Dea, S., 1995, Molecular analysis of the orfs 3 to 7 of porcine reproductive and respiratory syndrome virus, Quebec Reference Strain. Arch. Virol. 140: 1405–1418.PubMedCrossRefGoogle Scholar
  6. Murtaugh, M.R, Elam, M.R., and Kakach, L.T., 1995, Comparison of structural protein coding Sequences of the Vr-2332 and Lelystad virus strains of the PRRS virus. Arch. Virol. 140: 1451–1460.PubMedCrossRefGoogle Scholar
  7. Nelson, E.A., Cristopher-Hennings, J., Drew, T., Wensvoord, G., Collins, J.E., and Benfield, D.A., 1993, Differentiation of U.S. and European isolates of porcine reproductive and respiratory syndrome virus by monoclonal antibodies, J. Clin. Microbiol. 31: 3184–3189.PubMedGoogle Scholar
  8. Suarez, P., Zardoya, R., Jesus-Martin, M., Prieto, C., Dopazo, J., Solana, A., and Castro, J.M., 1996, Phylogenic relationships of European strains of porcine reproductive and respiratory syndrome virus (PRRSV) inferred from DNA sequences of putative orf-5 and orf-7 genes. Virus Res. 42: 159–165.PubMedCrossRefGoogle Scholar
  9. Wensvoort, G., M. DeKluyver, E.R, Luijtze E.A., DenBesten, A., Harris L., Collins, J.E., Christianson, W.T., and Chladek, D., 1992, Antigenic comparison of Lelystad virus and swine infertility and respiratory syndrome (SIRS) virus, J. Vet. Diag. Investi., 4: 134–138.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • P. A. M. van Woensel
    • 1
  • K. Liefkens
    • 1
  • S. Demaret
    • 1
  1. 1.Intervet International B.VBoxmeerThe Netherlands

Personalised recommendations