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Role of Mouse Hepatitis Virus-A59 Receptor Bgp1a Expression in Virus-Induced Pathogenesis

  • Catherine Godfraind
  • Kathryn V. Holmes
  • Jean-Paul Coutelier
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 440)

Abstract

Expression of Bgp1a, a glycoprotein that serves as receptor for mouse hepatitis virus-A59 has been analyzed in various mouse tissues and correlated with the pathogenicity that this virus induces in the corresponding organs. Expression of Bgpla was observed in many cells of epithelial origin, including hepatocytes and endothelial cells. It was also shown on macrophages and B lymphocytes. Bgpla localization may easily explain infection and lysis of some cell types like hepatocytes. In contrast, other cell types that express the viral receptor are not infected after in vivo inoculation with mouse hepatitis virus-A59, which may be due to inaccessibility of the receptor to the virus during mouse infection, or to resistance to this virus in some cell types. This may account for the ability of the blood-brain barrier to prevent mouse hepatitis virus-A59 spreading into the central nervous system. In other organs, the virus may induce pathogenesis indirectly, resulting in the destruction of cells that do not express Bgpla, like thymic lymphocytes, or else impair cell functions such as cytokine and immunoglobulin production by macrophages and B lymphocytes, respectively.

Keywords

Viral Receptor Thymus Involution Mouse Hepatitis Virus Polyclonal Activation Thymic Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Catherine Godfraind
    • 1
  • Kathryn V. Holmes
    • 3
  • Jean-Paul Coutelier
    • 2
  1. 1.Laboratory of PathologyCatholic University of LouvainBruxellesBelgium
  2. 2.Unit of Experimental MedicineCatholic University of LouvainBruxellesBelgium
  3. 3.Department of MicrobiologyUniversity of Colorado Health Sciences CenterDenverUSA

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