Reproduction of Lesions and Clinical Signs with a CNF2-Producing Escherichia Coli in Neonatal Calves

  • Sigrid Van Bost
  • Jacques Mainil
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 473)


CNF2-producing necrotoxigenic E. coli (NTEC2) are associated with diarrhoea and septicaemia in calves. We orally inoculated neonatal calves with a NTEC2 strain in order to reproduce clinical signs and lesions. We observed diarrhoea in each inoculated calf, bacteraemia (80%), the presence of CNF2+ bacteria in the lungs (80%) and in the liver (20%). The observed lesions were inflammation of the entire gut, hypertrophy of the mesenteric lymph nodes and hepatisation of the lungs. We were unable to detect characteristic lesions that are classical signs of septicaemia.


Mesenteric Lymph Node Post Inoculation Fecal Excretion Heart Blood Neonatal Calf 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Sigrid Van Bost
    • 1
  • Jacques Mainil
    • 1
  1. 1.Faculty of Veterinary Medicine Laboratory of BacteriologyUniversity of LiègeLiègeBelgium

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