Construction of a Recombinant Adenovirus for the Expression of the Glycoprotein S Antigen of Porcine Respiratory Coronavirus
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Efforts to develop respiratory and enteric vaccines focus on the efficient delivery of protective antigens to the mucosal lymphoid tissue. One approach is to use recombinant viral vectors, i.e. apathogenic viruses with a tropism for mucosal surfaces and genetically manipulated to express the protective antigens. Adenoviruses, particularly the human adenovirus type 5 (Ad5), are promising candidates for use as vectors.
KeywordsRecombinant Adenovirus Protective Antigen Transmissible Gastroenteritis Virus Polymerase Chain Reaction Process Recombinant Viral Vector
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