Advertisement

Coronaviruses pp 449-453 | Cite as

Structural Proteins of Avian Infectious Bronchitis Virus: Role in Immunity and Protection

  • Jagoda Ignjatovic
  • Lisa Galli
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)

Abstract

The antigenicity of the Sl, M and N proteins of avian infectious bronchitis virus was compared following immunization of chickens with live and inactivated virus. The N protein was immunodominant antigen inducing cross-reactive antibodies in high titres whereas the Sl glycoprotein induced serotype-specific and cross-reactive antibodies. The M glycoprotein elicited antibodies in low titres and of limited cross-reactivity. Immunization of chickens with the purified N and M proteins did not induce protection against virulent challenge whereas immunization with the Sl glycoprotein prevented replication of nephropathogenic IBV in kidneys but not in tracheas of immunized chickens.

Keywords

Newcastle Disease Virus Haemagglutination Inhibition Infectious Bronchitis Virus Virulent Challenge Virus Neutralization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. (1).
    Cavanagh, D. (1981). J. Gen. Virol. 53: 93.PubMedCrossRefGoogle Scholar
  2. (2).
    Cavanagh, D. (1983). J. Gen. Virol. 64: 1187.PubMedCrossRefGoogle Scholar
  3. (3).
    Cavanagh, D., Darbyshire, J. H., Davis, P. and Peters, R. W. (1984). Avian Pathol. 13: 573.PubMedCrossRefGoogle Scholar
  4. (4).
    Cavanagh, D., Davis, P. J., Darbyshire, J. H. and Peters, R. W. (1986). J. Gen. Virol. 67: 1435.PubMedCrossRefGoogle Scholar
  5. (5).
    Mockett, A. P. A., Cavanagh, D. and Brown, T. D. K. (1984). J. Gen. Virol. 65; 2281.PubMedCrossRefGoogle Scholar
  6. (6).
    Darbyshire, J.H. In: Avian Immunology (Eds Rose, M.E., Payne, L.N. and Freeman, B.M.) British Poultry svcience Ltd, Edinburgh, 1981, pp 205.Google Scholar
  7. (7).
    Arvidson, Y., Tannock, G. A., Senthilsevan, A. & Zerbes, M. (1990). Arch. Virol. 111: 227.PubMedCrossRefGoogle Scholar
  8. (8).
    Mocket, A.A.P. (1985). J. Virol. Meth. 12: 271.CrossRefGoogle Scholar
  9. (9).
    Lenstra, J.A., Kusters, J.G., Koch, G. and van der Zeijst. (1989). Molec. Immunol. 26: 7.CrossRefGoogle Scholar
  10. (10).
    Boots, A.M.H., Kusters, J.G., van Noort, Zwaagstra, K.A., Rijke, E., van der Zeijst, B.A.M. and Hensen, E.J. (1991). Immunology 74: 8.PubMedGoogle Scholar
  11. (11).
    Boots, A.M.H., Benaissa-Trouw, Hesselnik, W., Rijke, E., Schrier C. and Hensen, E.J. (1992). Vaccine 10: 119.PubMedCrossRefGoogle Scholar
  12. (12).
    Hansony, H.J. and MCNughton, M.R. (1981). Arch. Vorol. 69: 33.CrossRefGoogle Scholar
  13. (13).
    Daniel, C. and Talbot, P.J. (1990). Virology 174: 87.PubMedCrossRefGoogle Scholar
  14. (14).
    Talbot, P.J., Dionne, G. and Lacroix, M. (1988). J. Virol. 62: 3032.PubMedGoogle Scholar
  15. (15).
    Koolen, M.J.M., Borist, M.A.J., Horzinek, M.C. and Spaan, W.J.M. (1990). J. Virol. 64: 6270.PubMedGoogle Scholar
  16. (16).
    Ignjatovic, J and McWaters, P.G. (1991). J. Gen. Virol. 72: 2915.PubMedCrossRefGoogle Scholar
  17. (17).
    Chubb, R., Huynh, V. and Bradley, R. (1988). Avian Pathol. 17: 371.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Jagoda Ignjatovic
    • 1
  • Lisa Galli
    • 1
  1. 1.CSIRO Division of Animal HealthParkvilleAustralia

Personalised recommendations