Structural Proteins of Avian Infectious Bronchitis Virus: Role in Immunity and Protection
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The antigenicity of the Sl, M and N proteins of avian infectious bronchitis virus was compared following immunization of chickens with live and inactivated virus. The N protein was immunodominant antigen inducing cross-reactive antibodies in high titres whereas the Sl glycoprotein induced serotype-specific and cross-reactive antibodies. The M glycoprotein elicited antibodies in low titres and of limited cross-reactivity. Immunization of chickens with the purified N and M proteins did not induce protection against virulent challenge whereas immunization with the Sl glycoprotein prevented replication of nephropathogenic IBV in kidneys but not in tracheas of immunized chickens.
KeywordsNewcastle Disease Virus Haemagglutination Inhibition Infectious Bronchitis Virus Virulent Challenge Virus Neutralization
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