Coronaviruses pp 443-448 | Cite as

Cytokine Induction in Vitro in Mouse Brain Endothelial Cells and Astrocytes by Exposure to Mouse Hepatitis Virus (MHV-4, JHM)

  • Jeymohan Joseph
  • James L. Grun
  • Fred D. Lublin
  • Robert L. Knobler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)


Mouse hepatitis virus (MHV-4, JHM) is a neurotropic coronavirus which causes a spectrum of disease ranging from fatal encephalomyelitis to demyelination in susceptible murine hosts (1). Both direct infection of oligodendrocytes and immune-mediated events have been reported to play a role in the pathologic events in the central nervous system (CNS) following MHV-4 infection (2–5). The identification of CD8+ T-cells, NK cells, B-cells and PMN in the CNS of MHV-JHM infected mice suggests that immune mechanisms may be playing a role in the virus-induced disease process (3–9).


Endothelial Cell Cytokine Induction Mouse Hepatitis Virus Cerebral Endothelial Cell Lymphocytic Choriomeningitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Bailey, O.T., Pappenheimer, A.M., and Cheever, F.S., 1949, J. Exp. Med., 90:195.PubMedCrossRefGoogle Scholar
  2. 2.
    Knobler, R.L., Haspel, M.V., and Oldstone, M.B.A., 1981, J. Exp. Med., 153:832.PubMedCrossRefGoogle Scholar
  3. 3.
    Knobler, R.L., Tunison, L.A., Lampert, P.W., and Oldstone, M.B.A., 1982, Am. J. Pathol., 109:157.PubMedGoogle Scholar
  4. 4.
    Wang, F-I., Stohlman, S.A., and Fleming, J.O., 1991, J. Neuroimmunol., 30:31.CrossRefGoogle Scholar
  5. 5.
    Williamson, J.S.P., Sykes, K.C., and Stohlman, S.A., 1991, J. Neuroimmunol., 32:199.PubMedCrossRefGoogle Scholar
  6. 6.
    Stohlman, S.A., Brayton, P.R., Harmon, R.C., Stevenson, R.G., Ganges, R.G., and Matsushima, G.K., 1983, Int. J. Cancer., 31:309.PubMedCrossRefGoogle Scholar
  7. 7.
    Welsh, R.M., Haspel, M.V., Parker, D.C., and Holmes, K.V., 1986, J. Immunol., 136:1454.PubMedGoogle Scholar
  8. 8.
    Natuck, R.J., and Welsh, R.M., 1987, J. Immunol., 138:877.Google Scholar
  9. 9.
    Zimprich, F., Winter, J., Wege, H., and Lassmann, H., 1991, Neuropathol. Applied. Neurobiol., 17:469.CrossRefGoogle Scholar
  10. 10.
    Frei, K., Leist, T.P., Meager, P., Gallo, P., Leppert, D., Zinkernagel, R.M. and Fontana, A., 1988, J. Exp. Med., 168:449.PubMedCrossRefGoogle Scholar
  11. 11.
    Frei, K., Malipiero, U.V., Leist, T.P., Zinkernagel, R.M., Schwab, M.E., and Fontana, A., 1989, Eur. J. Immunol., 19:689.PubMedCrossRefGoogle Scholar
  12. 12.
    Jirik, F.R., Podor, T.J., Hirano, T., Kishimoto, T., Loskutoff, D.J., Carson, D.A., and Lotz, M., 1989, J. Immunol., 142:144PubMedGoogle Scholar
  13. 13.
    Lieberman, A.P., Pitha, P.M., Shin, H.S., and Shin, M.L., 1989, PNAS., 86:6348.PubMedCrossRefGoogle Scholar
  14. 14.
    Shalaby, M.R., Waage, A., and Esperik, T., 1989, Cell. Immunol., 121:372.PubMedCrossRefGoogle Scholar
  15. 15.
    Sironi, M., Brevario, F., Prosperio, P., Biondi, A., Vecchi, A., Van Damme, J., Dejana, E., and Mantovani, A.,1989, J. Immunol., 142:549.PubMedGoogle Scholar
  16. 16.
    Beneveniste, E.N., Sparacio, S.M., Norris, J.G., Grenett, H.E., and Fuller, G.M., 1990, J. Neuroimmunol., 30:201.CrossRefGoogle Scholar
  17. 17.
    Joseph, J., Knobler, R.L., Lublin, F.D., and Hart, M.N., 1989, J. Neuroimmunol., 22:241.PubMedCrossRefGoogle Scholar
  18. 18.
    Joseph, J., Knobler, R.L., Lublin, F.D., and Hart, M.N., 1990, Adv. Exp. Med. Biol., 276:579.PubMedCrossRefGoogle Scholar
  19. 19.
    Joseph, J., Knobler, R.L., Lublin, F.D., and Hart, M.N., 1991, J. Neuroimmunol., 33:181.PubMedCrossRefGoogle Scholar
  20. 20.
    Houssiau, F.A., Bukasa, K., Sindic, C.J.M., Van Damme, J., and Van Snick, J., 1988, Clin. Exp. Immunol., 71:320.PubMedGoogle Scholar
  21. 21.
    Breen, E.C., Rezai, A.R., Nakajima, K., Beall, G.N., Mitsuyasu, R.T., Hirano, T., Kishimoto, T., and Martinez-Maza, O., 1990, J. Immunol., 144:480.PubMedGoogle Scholar
  22. 22.
    Nishimoto, N., Yoshizaki, K., Eiraku, N., Machigashira, K., Tagoh, H., Ogata, A., Kuritani, T., Osame, M., and Kishimoto, T., 1990, J. Neurol. Sci.,97:183.PubMedCrossRefGoogle Scholar
  23. 23.
    Cernetti, C., Steinman, R.M., and Granelli-Piperno, A., 1988, PNAS., 85:1605.PubMedCrossRefGoogle Scholar
  24. 24.
    Takai, Y., Wong, G.G., Clark, S.C., Burakoff, S.J., and Hermann, S.H., 1988, J. Immunol., 140:508.PubMedGoogle Scholar
  25. 25.
    Borish, L., Rosenbaum, R., Albury, L., and Clark, S., 1989, Cell. Immunol., 121:280.PubMedCrossRefGoogle Scholar
  26. 26.
    Le, J., and Vilcek, J.,1989, Lab. Invest., 61:588.PubMedGoogle Scholar
  27. 27.
    DeBault, L.E., Henriquez, E., Hart, M.N., and Cancilla, P.A., 1981, In Vitro., 17:480.PubMedCrossRefGoogle Scholar
  28. 28.
    Knobler, R.L., Cole, R., de Vellis, J., Lewicki, H., Buchmeier, M., and Oldstone, M.B.A., 1987, In Coronaviruses., M.M.C. Lai and S.A. Stohlman, eds. Plenum, New York, p. 231.CrossRefGoogle Scholar
  29. 29.
    McCarthy, K.D., and deVellis, J., 1980, J. Cell. Biol., 85:890.PubMedCrossRefGoogle Scholar
  30. 30.
    Jayaraman, S., Martin, C.A., and Dorf, M.E., 1990, J. Immunol., 144:942.PubMedGoogle Scholar
  31. 31.
    Maniatis, T., Fritsch, E.F. and Sambrook, J. 1982., Molecular Cloning, a Laboratory Manual.Google Scholar
  32. 32.
    Williams, R.K., Jiang, G.S., Snyder, S.W., Frana, M.F., and Holmes, K.V., 1990, J. Virol., 64:3817.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Jeymohan Joseph
    • 1
  • James L. Grun
    • 2
  • Fred D. Lublin
    • 1
  • Robert L. Knobler
    • 1
  1. 1.Division of Neuroimmunology, Department of NeurologyJefferson Medical CollegePhiladelphiaUSA
  2. 2.Department of BiochemistryJefferson Medical CollegePhiladelphiaUSA

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