Early Cellular Events in the Induction of Murine Hepatitis Virus (MHV-3) Induced Macrophage Procoagulant Activity (PCA)
- 307 Downloads
Interaction of a membrane receptor with its ligand results in the generation of second messengers which ultimately leads to alteration in cell function either by changes in nuclear transcription, or activation/inactivation of cellular enzymes by phosphorylation events. Although the cell-surface MHV receptor has been cloned and sequenced1, the biochemical events leading to the expression of MHV-3 induced PCA after the binding of the virus to its receptor are unknown.
KeywordsTissue Factor pertussIs Toxin Calcium Ionophore Phorbol Myristate Acetate Procoagulant Activity
- 2.Lyberg, T., Prydz, H. J. Biochem. 194,699, 1981.Google Scholar
- 5.Kucey, D., Cheung, P., Rotstein, O. Infect Immun. In press, 1992.Google Scholar
- 7.Edgington, T., Pizzalato, M. Thromb. Haemostasis. 50,148, 1983.Google Scholar
- 14.Freissmuth, M., Casey, P., Gilman, A. FASEB J. 3,2126, 1989.Google Scholar