Coronaviruses pp 385-388 | Cite as

Early Cellular Events in the Induction of Murine Hepatitis Virus (MHV-3) Induced Macrophage Procoagulant Activity (PCA)

  • S. Chung
  • G. Downey
  • O. Rotstein
  • G. Levy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)


Interaction of a membrane receptor with its ligand results in the generation of second messengers which ultimately leads to alteration in cell function either by changes in nuclear transcription, or activation/inactivation of cellular enzymes by phosphorylation events. Although the cell-surface MHV receptor has been cloned and sequenced1, the biochemical events leading to the expression of MHV-3 induced PCA after the binding of the virus to its receptor are unknown.


Tissue Factor pertussIs Toxin Calcium Ionophore Phorbol Myristate Acetate Procoagulant Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • S. Chung
    • 1
  • G. Downey
    • 2
  • O. Rotstein
    • 1
  • G. Levy
    • 2
  1. 1.Departments of SurgeryUniversity of TorontoTorontoCanada
  2. 2.Departments of MedicineUniversity of TorontoTorontoCanada

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