Coronaviruses pp 371-376 | Cite as

Role of Host Age and Genotype in Murine Enterotropic Coronavirus Infection

  • Stephen W. Barthold
  • Abigail L. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)


Enterotropic mouse hepatitis virus (MHV) is probably the most common form of MHV in contemporary laboratory mouse populations, but very little is known about its pathogenesis. In spite of a large volume of literature on MHV, most of these reports are related to the respiratory prototype strains of virus (1, 2). When several prototype MHV and enterotropic MHV strains were inoculated into infant mice, it became clear that different MHV strains produced two distinctly different patterns of disease: respiratory, in which virus disseminated from nasal epithelium to multiple target organs; or enterotropic, in which virus was largely restricted to intestine, with minimal dissemination (3). However, enterotropic MHV has been poorly characterized because of its fastidious and selective in vitro growth characteristics. Host age seems to significantly influence the outcome of disease in mice infected with enterotropic MHV (4–11), and host genotype may also be important in susceptibility to enterotropic MHV disease (12). These are well established factors in the pathogenesis of respiratory or polytropic MHV disease (1, 2). The present study systematically examined the relative susceptibility of inbred mice of different ages that have previously been shown to develop severe (BALB/cByJ) or mild (SJL/J) disease when inoculated oronasally with respiratory MHV-JHM (13). Pilot studies suggested that these mouse genotypes also display differential disease severity when infected with enterotropic MHV, strain Y (12).


Virus Titer Mesenteric Lymph Node Nasal Epithelium Glandular Stomach Mouse Hepatitis Virus 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Stephen W. Barthold
    • 1
  • Abigail L. Smith
    • 1
  1. 1.Section of Comparative MedicineYale University School of MedicineNew HavenUSA

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