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Coronaviruses pp 371-376 | Cite as

Role of Host Age and Genotype in Murine Enterotropic Coronavirus Infection

  • Stephen W. Barthold
  • Abigail L. Smith
Chapter
  • 251 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)

Abstract

Enterotropic mouse hepatitis virus (MHV) is probably the most common form of MHV in contemporary laboratory mouse populations, but very little is known about its pathogenesis. In spite of a large volume of literature on MHV, most of these reports are related to the respiratory prototype strains of virus (1, 2). When several prototype MHV and enterotropic MHV strains were inoculated into infant mice, it became clear that different MHV strains produced two distinctly different patterns of disease: respiratory, in which virus disseminated from nasal epithelium to multiple target organs; or enterotropic, in which virus was largely restricted to intestine, with minimal dissemination (3). However, enterotropic MHV has been poorly characterized because of its fastidious and selective in vitro growth characteristics. Host age seems to significantly influence the outcome of disease in mice infected with enterotropic MHV (4–11), and host genotype may also be important in susceptibility to enterotropic MHV disease (12). These are well established factors in the pathogenesis of respiratory or polytropic MHV disease (1, 2). The present study systematically examined the relative susceptibility of inbred mice of different ages that have previously been shown to develop severe (BALB/cByJ) or mild (SJL/J) disease when inoculated oronasally with respiratory MHV-JHM (13). Pilot studies suggested that these mouse genotypes also display differential disease severity when infected with enterotropic MHV, strain Y (12).

Keywords

Virus Titer Mesenteric Lymph Node Nasal Epithelium Glandular Stomach Mouse Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Barthold, S.W. 1986. In T.C. Hamm, (ed.), Complications of Viral and Mycoplasmal Infections in Rodents to Toxicology Research and Testing, pp.53–89. Hemisphere Publishing Corporation, Washington, DCGoogle Scholar
  2. 2.
    Barthold, S.W. 1986. In P.N. Bhatt, et al. (eds), Viral and Mycoplasmal Infections of Laboratory Rodents: Effects on Biomedical Research, pp. 571–601. Academic Press, New York, NY.CrossRefGoogle Scholar
  3. 3.
    Barthold, S.W. and A.L. Smith. 1984. Arch. Virol. 81:103–112.PubMedCrossRefGoogle Scholar
  4. 4.
    Kraft, L.M. 1962. Science 137:282–283.PubMedCrossRefGoogle Scholar
  5. 5.
    Biggers, D.C. et al. 1964. Amer. J. Pathol. 45:413–422.Google Scholar
  6. 6.
    Kraft, L.M. 1966. NCI Monograph 20:55–61.Google Scholar
  7. 7.
    Barthold, S.W. et al. 1982. Lab.Anim. Sci. 32:376–383.PubMedGoogle Scholar
  8. 8.
    Broderson, J.R. et al. 1976. Lab. Anim. Sci. 26:824.PubMedGoogle Scholar
  9. 9.
    Hierholzer, J.C. et al. 1979. Inf. Immun. 24:508–522.Google Scholar
  10. 10.
    Carthew, P. 1977. Vet. Rec.101:465.PubMedCrossRefGoogle Scholar
  11. 11.
    Ishida, T. and K. Fujiwara. 1979. Jap. J. Exp. Med. 52:231–35.Google Scholar
  12. 12.
    Barthold, S.W. 1987. Lab. Anim. Sci. 37:36–40.PubMedGoogle Scholar
  13. 13.
    Barthold, S.W. and A.L. Smith. 1987. Virus Res. 7:225–239.PubMedCrossRefGoogle Scholar
  14. 14.
    Smith, A.L. and D.F. Winograd. 1986. J. Virol. Methods 14:335–343PubMedCrossRefGoogle Scholar
  15. 15.
    Tsuboi, K.K. et al. 1985. Biochim. Biophys. Acta 840:69–78.PubMedCrossRefGoogle Scholar
  16. 16.
    Tsuboi, K.K. et al. 1981. Biochim. Biophys. Res. Comn. 101:645–652CrossRefGoogle Scholar
  17. 17.
    Williams, R.K. et al. 1990. J. Virol. 64:3817–3823.PubMedGoogle Scholar
  18. 18.
    Barthold, S.W. et al. 1985. Lab. Anim. Sci. 35:613–618.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Stephen W. Barthold
    • 1
  • Abigail L. Smith
    • 1
  1. 1.Section of Comparative MedicineYale University School of MedicineNew HavenUSA

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