Coronaviruses pp 261-266 | Cite as

Coronavirus Receptor Specificity

  • Kathryn V. Holmes
  • Gabriela Dveksler
  • Sara Gagneten
  • Curtis Yeager
  • Sue-Hwa Lin
  • Nicole Beauchemin
  • A. Thomas Look
  • Richard Ashmun
  • Carl Dieffenbach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)


Bang and his colleagues first showed the importance of the host in determining susceptibility to coronavirus infection, using mouse hepatitis virus MHV-2 as a model system which could cause death of Pri mice but not of C3H mice or macrophages isolated from them (1). Subsequently, as additional coronaviruses were recognized, it became clear that these viruses generally have narrow host ranges and show marked tissue specificity for replication (2). We have studied the importance of virus-receptor interactions in the host range and tissue tropism of coronavirus infections.


Lacrimal Gland Brush Border Membrane Tissue Tropism Virus Receptor Mouse Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Kathryn V. Holmes
    • 1
  • Gabriela Dveksler
    • 1
  • Sara Gagneten
    • 1
  • Curtis Yeager
    • 2
  • Sue-Hwa Lin
    • 3
  • Nicole Beauchemin
    • 4
  • A. Thomas Look
    • 5
  • Richard Ashmun
    • 5
    • 6
  • Carl Dieffenbach
    • 7
  1. 1.Department of PathologyUniformed Services University of the Health SciencesBethesdaUSA
  2. 2.Department of MicrobiologyUniformed Services University of the Health SciencesBethesdaUSA
  3. 3.Department of BiochemistryBaylor University School of MedicineHoustonUSA
  4. 4.McGill Cancer CenterMontrealCanada
  5. 5.Departments of Experimental Oncology and Tumor Cell BiologySt Jude Children’s Research HospitalMemphisUSA
  6. 6.Department of PediatricsUniversity of Tennessee College of MedicineMemphisUSA
  7. 7.Division of AIDSNIAID, NIHBethesdaUSA

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