RNA Synthesis and mRNA Editing in Paramyxovirus Infections

  • Joseph Curran
  • Thierry Pelet
  • Jean-Philippe Jacques
  • Daniel Kolakofsky
Part of the NATO ASI Series book series (NSSA, volume 240)


Paramyxoviruses contain nonsegment ssRNA genomes of around 15 kB and negative polarity, i.e., complementary to the viral mRNAs. These genomes (and negative-strand viral genomes in general) function not as free nucleic acid, but as helical nucleocapsids (NC) assembled with the viral nucleoprotein (NP) in which the genome RNA represents only 4% by weight. It is these nucleocapsids which are the templates for RNA synthesis. The vrial polymerase is composed of two subunits, the phosphoprotein P and the large protein L, but its overall structure is unclear.


Insertion Site Editing Site mRNA Synthesis Sendai Virus Mumps Virus 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Joseph Curran
    • 1
  • Thierry Pelet
    • 1
  • Jean-Philippe Jacques
    • 1
  • Daniel Kolakofsky
    • 1
  1. 1.Department of Genetics and MicrobiologyUniversity of Geneva School of Medicine CMUGenevaSwitzerland

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