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Membrane Cycling between the ER and Golgi Apparatus and Its Role in Biosynthetic Transport

  • Jennifer Lippincott-Schwartz
Chapter
Part of the Subcellular Biochemistry book series (SCBI, volume 21)

Abstract

Selective localization and transport of protein and lipid within eukaryotic cells requires the proper functioning of an intercommunicating “endomembrane” system characterized by distinct membrane-bound compartments and membrane transport pathways. Two organelles that play a key role in the generation and maintenance of this endomembrane system, as well as in membrane targeting within it, are the ER and Golgi apparatus. All newly synthesized proteins enter the endomembrane system in the ER and only move to different final destinations in the cell after passing through the Golgi apparatus. This fundamental relationship between the ER and Golgi apparatus in the regulation and sorting events of biosynthetic transport was first recognized in the 1960s (Palade, 1975). Only recently, however, has insight into the underlying mechanisms of membrane traffic between the ER and Golgi apparatus been achieved, because of the development of new biochemical, pharmacologie, genetic, and morphologic approaches.

Keywords

Endoplasmic Reticulum Golgi Apparatus Golgi Complex Retrograde Transport Golgi Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jennifer Lippincott-Schwartz
    • 1
  1. 1.Cell Biology and Metabolism Branch, National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaUSA

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