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Mechanisms of DE — and Remyelination in Autoimmune Encephalomyelitis and Multiple Sclerosis

  • Hans Lassmann
  • Gerda Suchanek
  • Mascha Schmied
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Part of the NATO ASI Series book series (NSSA, volume 258)

Abstract

Several different immunopathological mechanisms have been suggested to be involved in the destruction of myelin in inflammatory demyelinating diseases. They include destruction of oligodendrocytes by virus infection1 as well as immune mediated damage by macrophage products2, specific antibodies3 or T-lymphocytes4. To evaluate the validity of these concepts it is of critical importance to determine the fate of oligodendrocytes within the lesions5,6,7,8. This, however, was difficult and inconclusive because of the lack of specific and sensitive markers that allow the identification of oligodendrocytes in demyelinated plaques. Recently, new techniques became available to address this question, which have been applied in the present study.

Keywords

Multiple Sclerosis Experimental Allergic Encephalomyelitis Nick Translation Central Nervous System Tissue Inflammatory Demyelinating Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Hans Lassmann
    • 1
    • 2
  • Gerda Suchanek
    • 1
  • Mascha Schmied
    • 1
  1. 1.Research Unit for Experimental NeuropathologyAustrian Academy of SciencesAustria
  2. 2.Neurological InstituteUniversity ViennaAustria

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