Evidence for a Pseudoknot in the 3′ Untranslated Region of the Bovine Coronavirus Genome

  • G. D. Williams
  • R.-Y. Chang
  • D. A. Brian
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 380)


A potential pseudoknot was found in the 3′ untranslated region of the bovine coronavirus genome beginning 63 nt downstream from the stop codon of the N gene. Mutation analysis of the pseudoknot in a cloned defective interfering RNA indicated that this structural element is necessary for defective interfering RNA replication.


Brome Mosaic Virus Large Open Reading Frame Pseudoknotted Structure Bovine Coronavirus Corona Virus 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • G. D. Williams
    • 1
  • R.-Y. Chang
    • 2
  • D. A. Brian
    • 2
  1. 1.Program in BiotechnologyUniversity of TennesseeKnoxvilleUSA
  2. 2.Department of MicrobiologyUniversity of TennesseeKnoxvilleUSA

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