Characterization of the S Protein of Enterotropic Murine Coronavirus Strain-Y

  • Susan R. Compton
  • Satoshi Kunita
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 380)


The pathogenesis of enterotropic murine coronavirus strain MHV-Y differs extensively from that of prototypic respiratory strains of murine coronaviruses. The S protein of MHV-Y was characterized as a first step towards identifying viral determinants of enterotropism. Immunoblots of MHV-Y virions using anti-S protein specific antiserum revealed that the MHV-Y S protein was inefficiently cleaved. The MHV-Y S gene was cloned and sequenced. It encodes a protein predicted to be 1361 amino acids long. The presence of several amino acids changes within and surrounding the predicted cleavage site of the MHV-Y S protein may contribute to its inefficient cleavage.


Mouse Hepatitis Virus Cleavage Signal Predict Cleavage Site Goat Antiserum Cleavage Signal Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Susan R. Compton
    • 1
  • Satoshi Kunita
    • 1
  1. 1.Section of Comparative MedicineYale University School of MedicineNew HavenUSA

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