Echocardiographic Changes Following Rabbit Coronavirus Infection
- 202 Downloads
Much of our understanding of the mechanisms by which viruses cause myocarditis and/or dilated cardiomyopathy (DCM) is based on animal models of virus-induced heart disease. Information concerning cardiac function during acute and/or chronic viral infection in these models is limited (1). A well defined model in a species conducive to monitoring of cardiac function is needed to enhance our understanding of viral induced heart disease. We have previously demonstrated that rabbit coronavirus (RbCV) infection results in degeneration and necrosis of myocytes, myocarditis, and gross organ and histopathologic changes of DCM (2,3). We have also shown that electrocardiographic changes observed during RbCV infection mimic those in humans with myocarditis and DCM (submitted). This chapter describes the echocardiographic changes observed during RbCV infection.