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Echocardiographic Changes Following Rabbit Coronavirus Infection

  • Lorraine K. Alexander
  • Bruce W. Keene
  • Ralph S. Baric
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 380)

Abstract

Much of our understanding of the mechanisms by which viruses cause myocarditis and/or dilated cardiomyopathy (DCM) is based on animal models of virus-induced heart disease. Information concerning cardiac function during acute and/or chronic viral infection in these models is limited (1). A well defined model in a species conducive to monitoring of cardiac function is needed to enhance our understanding of viral induced heart disease. We have previously demonstrated that rabbit coronavirus (RbCV) infection results in degeneration and necrosis of myocytes, myocarditis, and gross organ and histopathologic changes of DCM (2,3). We have also shown that electrocardiographic changes observed during RbCV infection mimic those in humans with myocarditis and DCM (submitted). This chapter describes the echocardiographic changes observed during RbCV infection.

Keywords

Dilate Cardiomyopathy Short Axis View Left Ventricular Wall Thickness Chronic Viral Infection Left Atrial Diameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Woodruff JF. Am J Pathol 1980;101:427–84.Google Scholar
  2. 2.
    Edwards S. et al. J Infect Dis 1992;165:134–40.PubMedCrossRefGoogle Scholar
  3. 3.
    Alexander LK. et al. J Infect Dis 1992;166:978–85PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Lorraine K. Alexander
    • 1
    • 2
  • Bruce W. Keene
    • 1
    • 2
  • Ralph S. Baric
    • 1
    • 2
  1. 1.The Department of EpidemiologyThe University of North Carolina at Chapel HillChapel HillUSA
  2. 2.The College of Veterinary MedicineNorth Carolina State UniversityRaleighUSA

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