The Role of Chemokines in the Recruitment of Leukocytes During Lung Inflammation

  • Robert M. Strieter
  • John A. Belperio
  • David Kelley
  • Ammar Sakkour
  • Michael P. Keane
Part of the Molecular and Cellular Biology of Critical Care Medicine book series (MCCM, volume 1)


The recruitment of specific leukocyte subpopulations in response to lung injury is a fundamental mechanism of acute pulmonary inflammation. The elicitation of leukocytes is dependent upon a complex series of events, including reduced leukocyte deformability, endothelial cell activation and expression of endothelial cell-derived leukocyte adhesion molecules, leukocyte-endothelial cell adhesion, leukocyte activation and expression of leukocyte-derived adhesion molecules, leukocyte transendothelial migration, and leukocyte migration beyond the endothelial barrier along established chemotactic and haptotactic gradients. While the events of leukocyte extravasation may appear intuitive, it has taken over 150 years of research to elucidate the molecular and cellular steps involved in the process of leukocyte migration.


Lung Injury Acute Lung Injury Chemokine Receptor Cryptococcus Neoformans Adult Respiratory Distress Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Robert M. Strieter
    • 1
  • John A. Belperio
    • 1
  • David Kelley
    • 1
  • Ammar Sakkour
    • 1
  • Michael P. Keane
    • 1
  1. 1.Department of Medicine, Division of Pulmonary and Critical Care MedicineUniversity of California, Los Angeles (UCLA) School of MedicineLos AngelesUSA

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