Differential Expression of Tumor Necrosis Factor in Primary Glial Cell Cultures Infected with Demyelinating and Non-Demyelinating MHVs
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TNF-α is a monocyte/macrophage derived cytokine with multiple biological activities that are antitumorigenic, cytotoxic, and pro-inflammatory in nature. TNF-α mediates cellular response through two distinct cell surface receptors, TNF-Rl(p55) and TNF-R2(p75) (Barbara et al 1996). TNF-α appears to have a diverse range of functions in the CNS due to its effect on astrocytes and oligodendrocytes. These include: induction of MHC class I Ag on astrocytes (Lavi et al 1988; Mauerhoff et al 1988), induction of ICAM-1, up-regulation of MHC class II Ag induced by IFN-γ and/or virus on astrocytes, stimulation of IL-6 secretion by astrocytes, myelin damage (Selmaj and Raine 1988) and lysis of oligodendrocytes (Robbins et al 1987).
KeywordsMajor Histocompatibility Complex Class Post Infection Astrocyte Culture Mouse Hepatitis Virus Mouse Astrocyte
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