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Differential Expression of Tumor Necrosis Factor in Primary Glial Cell Cultures Infected with Demyelinating and Non-Demyelinating MHVs

  • Li Fu
  • Jayasri Das Sarma
  • Ehud Lavi
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)

Abstract

TNF-α is a monocyte/macrophage derived cytokine with multiple biological activities that are antitumorigenic, cytotoxic, and pro-inflammatory in nature. TNF-α mediates cellular response through two distinct cell surface receptors, TNF-Rl(p55) and TNF-R2(p75) (Barbara et al 1996). TNF-α appears to have a diverse range of functions in the CNS due to its effect on astrocytes and oligodendrocytes. These include: induction of MHC class I Ag on astrocytes (Lavi et al 1988; Mauerhoff et al 1988), induction of ICAM-1, up-regulation of MHC class II Ag induced by IFN-γ and/or virus on astrocytes, stimulation of IL-6 secretion by astrocytes, myelin damage (Selmaj and Raine 1988) and lysis of oligodendrocytes (Robbins et al 1987).

Keywords

Major Histocompatibility Complex Class Post Infection Astrocyte Culture Mouse Hepatitis Virus Mouse Astrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Barbara, J. A. J., X. V. Ostande, and A. F. Lopez. 1996. Tumor necrosis factor-alpha: the good, the bad and potentially very effective. Immunology and Cell Biology. 74:434–443.PubMedCrossRefGoogle Scholar
  2. Budzilowicz, C. J., S. P. Wilczynski, and S. R. Weiss. 1985. Three intergenic regions of mouse hepatitis virus strain A59 genome RNA contain a common nucleotide sequence that is homologous to the 3’ end of the viral mRNA leader sequence. J. Virol. 53:834–840.PubMedGoogle Scholar
  3. Chung, I. L. Y., and E. N. Benveniste. 1990. Tumor necrosis factor — a production by astrocytes. J. Immunol. 144:2999–3007.PubMedGoogle Scholar
  4. Chung, I. L. Y., J. G. Norris, and E. N. Benveniste. 1991. Differential tumor necrosis factor a expression by astrocytes from experimental allergic encephalomyelitis-susceptible and resistant rat strains. J. Exp. Med. 173:801–811.PubMedCrossRefGoogle Scholar
  5. Keck, J. G., L. H. Soe, S. Makino, S. A. Stohlman, and M. M. C. Lai. 1988. RNA recombination of murine Coronavirus: recombination between fusion-positive mouse hepatitis virus A59 and fusion-negative mouse hepatitis virus 2. J. Virol. 62:1989–1998.PubMedGoogle Scholar
  6. Lavi, E., D. H. Gilden, Z. Wroblewska, L. B. Rorke, and S. R. Weiss. 1984. Experimental demyelination produced by the A59 strain of mouse hepatitis virus. Neurology. 34:597–603.PubMedCrossRefGoogle Scholar
  7. Lavi, E., A. Susumura, D. M. Murasko, E. M. Murray, D. H. Silberberg, and S. R. Weiss. 1988. Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes. J. Neuroimmunol. 18:245.PubMedCrossRefGoogle Scholar
  8. Mauerhoff, T., R. Pujol-Borrell, R. Mirakan, and G. F. Bottazzo. 1988. Differential expression and regulation of major histocompatibility complex (MHC) products in neural and glial cells of the human fetel brain. J Neuroimmunol. 18:271.PubMedCrossRefGoogle Scholar
  9. Robbins, D. S., Y. Shirazi, B. E. Drysdale, A. Leiberman, H. S. Shin, and M. L. Shin. 1987. Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes. J. Immunol. 139:2593.PubMedGoogle Scholar
  10. Selmaj, K. W., and C. S. Raine. 1988. Tumor necrosis factor mediates myelin and oligodendrocytes damage in vitro. Ann. Neurol. 23:339.PubMedCrossRefGoogle Scholar
  11. Shahar, A., J. D. Vellis, A. Vermadakis, and B. Haber (ed.). 1989. A dissection and tissue culture mannual of the nervous system. Alan R. Liss, Inc., New York.Google Scholar
  12. Stohlman, S. A., and L. P. Weiner. 1981. Chronic central nervous system demyelination in mice after JHM virus infection. Neurology. 31:38–44.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Li Fu
    • 1
  • Jayasri Das Sarma
    • 1
  • Ehud Lavi
    • 1
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania, School of MedicinePhiladelphiaUSA

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