Acute CNS Infection is Insufficient to Mediate Chronic T Cell Retention
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CD8+ T cells control infection by the neurotropic JHM strain of mouse hepatitis virus (JHMV) by eliminating infectious virus and reducing CNS pathology (Stohlman et al. 1995). Virus-specific CTL in BALB/c mice (H-2d) respond almost exclusively to a single immunodominant epitope in the nucleocapsid (N) protein (Bergmann et al. 1993). During acute JHMV infection, CD8+ T cells account for up to 40% of CNS mononuclear cells (MNC) (Bergmann et al. 1999). Following viral clearance, virus specific CD8+ T cells remain in CNS for several weeks (Bergmann et al. 1999).
KeywordsSpinal Cord Infected Mouse Infectious Virus Viral Persistence Cell Retention
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