Advertisement

Human Coronavirus HCoV-229E Enters Susceptible Cells via the Endocytic Pathway

  • Dianna M. Blau
  • Kathryn V. Holmes
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)

Abstract

Human coronaviruses (HCoV) are important causes of upper respiratory infections in humans of all ages. In addition, HCoVs have occasionally been associated with pneumonia, meningitis and diarrhea. HCoV RNA has been detected by RT-PCR in up to 40% of adult human brains (Stewart et al., 1992). There are two serotypes of HCoV represented by HCoV-229E and HC0V-0C43. HCoV-229E is a member of Coronavirus serogroup I, which also includes porcine transmissible gastroenteritis virus (TGEV) and feline and canine coronaviruses. The viral attachment protein S of HCoV-229E is unlike S proteins of many coronaviruses in serogroup II, in that it is not cleaved during virus assembly, nor does it cause syncytia formation.

Keywords

Apical Surface Endocytic Pathway Mouse Hepatitis Virus Cell BioI Human Coronaviruses 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Hansen, G. H., Delmas, B., Besnardeau, L., Vogel, L. K., Laude, H., Sjostrom, H., and Noren, O., 1998, The Coronavirus transmissible gastroenteritis virus causes infection after receptor-mediated endocytosis and acid-dependent fusion with an intracellular compartment. J. Virol. 72:527–534.PubMedGoogle Scholar
  2. Hernandez, L. D., Hoffman, L. R., Wolfsberg, T. G., and White, J. M., 1996, Virus-cell and cell-cell fusion. Annu. Rev. Cell Dev. Biol. 12:627–661.PubMedCrossRefGoogle Scholar
  3. Gruenberg, J., and Howell, K. E., 1989, Membrane traffic in endocytosis: insights from cell-free assays. Annu. Rev. Cell Biol. 5:453–481.PubMedCrossRefGoogle Scholar
  4. Kooi, C., Cervin, M., and Anderson R., 1991, Differentiation of acid-pH-dependent and-nondependent entry pathways for mouse hepatitis virus. Virology. 180:108–119.PubMedCrossRefGoogle Scholar
  5. Lachance, C., Arbour, N., Cashman, N. R., and Talbot, P. J., 1998, Involvement of aminopeptidase N (CD13) in infection of human neural cells by human Coronavirus 229E. J. Virol. 72:6511–6519.PubMedGoogle Scholar
  6. Lamarre, A., and Talbot, P. J., 1989, Effect of pH and temperature on the infectivity of human Coronavirus 229E. Can. J. Microbiol. 35:972–974.PubMedCrossRefGoogle Scholar
  7. Laude, H., Gelfi, J., and Aynaud, J. M., 1981, In vitro properties of low-and high-passage strains of gastroenteritis Coronavirus of swine. Am. J. Vet. Res. 42:447–449.PubMedGoogle Scholar
  8. LeBivic, A., Quaroni, A., Nichols, B., and Rodriguez-Boulan, E., 1990, Biogenic pathways of plasma membrane proteins in Caco-2, a human intestinal epithelial cell line. J. Cell Biol. 111:1351–1361.CrossRefGoogle Scholar
  9. Look, A. T., Ashmun, R. A., Shapiro, L. H., and Peiper, S. C., 1989, Human myeloid plasma membrane glycoprotein CD 13 (gpl50) is identical to aminopeptidase N. J. Clin. Invest. 83:1299–1307.PubMedCrossRefGoogle Scholar
  10. Stewart, J. N., Mounir, S., and Talbot, P. J., 1992, Human Coronavirus gene expression in the brains of multiple sclerosis patients. Virology 191:502–505.PubMedCrossRefGoogle Scholar
  11. Sturman, L. S., Ricard, C. S., and Holmes, K. V., 1990, Conformational change of the Coronavirus peplomer glycoprotein at pH 8.0 and 37° C correlates with virus aggregation and virus-induced cell fusion. J. Virol. 64:3042–3050.PubMedGoogle Scholar
  12. Tooze, J., Tooze, S. A., and Fuller, S. D., 1987, Sorting of progeny Coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells. J. Cell Biol. 105:1215–1226.PubMedCrossRefGoogle Scholar
  13. Tooze, J., Tooze, S., and Warren, G., 1984, Replication of Coronavirus MHV-A59 in sac-cells: determination of the first site of budding of progeny virions. Eur. J. Cell Biol. 33:281–293.PubMedGoogle Scholar
  14. Wang, G., Deering, C., Macke, M., Shao, J., Burns, R., Blau, D. M., Holmes, K. V., Davidson, B. L., Perlman, S., and McCray Jr., P. B., 2000, Human Coronavirus 229E infects polarized airway epithelia from the apical surface. Submitted to J. Virol.Google Scholar
  15. Yeager, C. L., Ashmun, R. A., Williams, R. K., Cardellichio, C. B., Shapiro, L. H., Look, A. T., and Holmes, K. V., 1992, Human aminopeptidase N is a receptor for human Coronavirus 229E. Nature 357:420–422.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Dianna M. Blau
    • 1
  • Kathryn V. Holmes
    • 1
  1. 1.Department of MicrobiologyUniversity of Colorado Health Sciences CenterDenverUSA

Personalised recommendations