Human Coronavirus HCoV-229E Enters Susceptible Cells via the Endocytic Pathway
- 163 Downloads
Human coronaviruses (HCoV) are important causes of upper respiratory infections in humans of all ages. In addition, HCoVs have occasionally been associated with pneumonia, meningitis and diarrhea. HCoV RNA has been detected by RT-PCR in up to 40% of adult human brains (Stewart et al., 1992). There are two serotypes of HCoV represented by HCoV-229E and HC0V-0C43. HCoV-229E is a member of Coronavirus serogroup I, which also includes porcine transmissible gastroenteritis virus (TGEV) and feline and canine coronaviruses. The viral attachment protein S of HCoV-229E is unlike S proteins of many coronaviruses in serogroup II, in that it is not cleaved during virus assembly, nor does it cause syncytia formation.
KeywordsApical Surface Endocytic Pathway Mouse Hepatitis Virus Cell BioI Human Coronaviruses
- Hansen, G. H., Delmas, B., Besnardeau, L., Vogel, L. K., Laude, H., Sjostrom, H., and Noren, O., 1998, The Coronavirus transmissible gastroenteritis virus causes infection after receptor-mediated endocytosis and acid-dependent fusion with an intracellular compartment. J. Virol. 72:527–534.PubMedGoogle Scholar
- Wang, G., Deering, C., Macke, M., Shao, J., Burns, R., Blau, D. M., Holmes, K. V., Davidson, B. L., Perlman, S., and McCray Jr., P. B., 2000, Human Coronavirus 229E infects polarized airway epithelia from the apical surface. Submitted to J. Virol.Google Scholar