Infection of Hemagglutinating Encephalomyelitis Virus (HEV) at the Visual Pathways of Rats
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Hemagglutinating encephalomyelitis virus (HEV) is neurotropic Coronavirus causing vomiting and wasting disease or encephalitis in piglets (Andries and Pensaert. 1981). In the infected animals, the virus reaches the CNS through the nerve pathways from peripheral nerve. Our previous studies have demonstrated that HEV propagated through nervous route and its infection was restricted to neurons after inoculation into sciatic nerve or footpad of rats (Hirano et al., 1995, 1998). Our findings suggest that HEV is useful as a trans-synaptic tracer for analyzing neuronal connections in the CNS. The present study was performed to examine and evaluate the usefulness of HEV as a trans-synaptic tracer in the visual pathway.
KeywordsSciatic Nerve Visual Cortex Herpes Simplex Virus Type Superior Colliculus Visual Pathway
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