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Infection of Hemagglutinating Encephalomyelitis Virus (HEV) at the Visual Pathways of Rats

  • Norio Hirano
  • Koujiro Tohyama
  • Nobuyo Ootani
  • Tsutomu Hashikawa
Chapter
  • 31 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)

Abstract

Hemagglutinating encephalomyelitis virus (HEV) is neurotropic Coronavirus causing vomiting and wasting disease or encephalitis in piglets (Andries and Pensaert. 1981). In the infected animals, the virus reaches the CNS through the nerve pathways from peripheral nerve. Our previous studies have demonstrated that HEV propagated through nervous route and its infection was restricted to neurons after inoculation into sciatic nerve or footpad of rats (Hirano et al., 1995, 1998). Our findings suggest that HEV is useful as a trans-synaptic tracer for analyzing neuronal connections in the CNS. The present study was performed to examine and evaluate the usefulness of HEV as a trans-synaptic tracer in the visual pathway.

Keywords

Sciatic Nerve Visual Cortex Herpes Simplex Virus Type Superior Colliculus Visual Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Norio Hirano
    • 1
  • Koujiro Tohyama
    • 2
    • 3
  • Nobuyo Ootani
    • 2
  • Tsutomu Hashikawa
    • 3
  1. 1.Department of Veterinary MicrobiologyIwate UniversityMoriokaJapan
  2. 2.Center for Electron Microscopy and Bio-Imaging Research, and Department of NeuroanatomyIwate Medical UniversityMoriokaJapan
  3. 3.Laboratory of Neural ArchitectureBrain Science Institute, RIKENWakoJapan

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