Effects of Heparin on the Entry of Porcine Reproductive and Respiratory Syndrome Virus into Alveolar Macrophages

  • N. Vanderheijden
  • P. Delputte
  • H. Nauwynck
  • M. Pensaert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)


Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease of swine that causes abortion and respiratory disorders, leading to important economic losses (Rossow, 1998). The PRRS virus (PRRSV) was first isolated in 1991 in the Netherlands (Wensvoort et al., 1991) and is a member of the Arteriviridae family, that was recently incorporated in the order Nidovirales (Cavanagh, 1997). Serological and genomic studies have revealed major strain differences among isolates, most markedly between those from the USA and Europe (Wensvoort et al., 1992; Bautista et al., 1993; Murtaugh, 1995).


Infected Cell Alveolar Macrophage Respiratory Syndrome Virus Virus Adsorption Porcine Alveolar Macrophage 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • N. Vanderheijden
    • 1
  • P. Delputte
    • 1
  • H. Nauwynck
    • 1
  • M. Pensaert
    • 1
  1. 1.Laboratory of Virology, Faculty of Veterinary MedicineGhent UniversityMerelbekeBelgium

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