Induction of Apoptosis in MRC-5, Diploid Human Fetal Lung Cells after Infection with Human Coronavirus OC43
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Human coronaviruses (HCoV) cause upper respiratory tract infections manifested by symptoms of the common cold including rhinitis, tussis, fever, headache and myalgia (Hruskova et al 1990). HCoV respiratory illness is primarily virus-mediated; immunologic events have not been postulated to play a role (Makela et al 1998). Evidence showing the presence of viral genome in spinal fluid and brain suggests that HCoV may play an etiologic role in multiple sclerosis (Stewart et al 1992, Cristallo et al 1997). However, the pathogenesis of HCoV infections is poorly understood. In human embryonic tracheal organ cultures, HCoV causes a slow patchy destruction of the ciliated epithelial cells and in respiratory epithelial tissue cultures, the cytopathic effect is subtle, evident only by vacuolization and spindling.
KeywordsMultiple Sclerosis Patient Internal Ribosome Entry Site Common Cold Mouse Hepatitis Virus Ciliated Epithelial Cell
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