Genetic Variation of ORFs 3 and 4 of Equine Arteritis Virus
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The open reading frames (ORFs) 3 and 4 of equine arteritis virus (EAV) encode the GP3 and GP4 proteins, respectively. The GP3 protein of EAV is an extensively glycosylated membrane protein that is likely anchored by the uncleaved signal sequence (Hedges et al., 1999a). ORF 4 is predicted to encode a membrane glycoprotein. The goal of this study was to determine the variation in ORFs 3 and 4 and their encoded GP3 and GP4 proteins amongst a large number of EAV strains, including those amplified directly from the semen of carrier stallions.
KeywordsGlycosylation Site Field Isolate Strong Selective Pressure Equine Arteritis Virus Infectious cDNA Clone
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