Proinflammatory Cytokines mRNA Expression in Dependence of Suppressive Epitope of Retroviral Transmembrane p15E Peptide Activation at Multiple Sclerosis Patients

  • Irina A. Goldina
  • Marina N. Tuzova
  • Alexander A. Smagin
  • Vitaly V. Morozov
  • Michel S. Lubarsky
  • Konstantin V. Gaidul
  • Vladimir A. Kozlov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 500)


Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with the autoimmune component. It is characterised by discrete, multifocus lesions of myelin degradation. All phenotypes of lymphocytes and activated macrophages are represented in the inflammatory infiltrates. Myelin basic protein reactive T cells, macrophages and microglia produce a wide range of factors, wich may influence oligodendrocyte function during the demyelinating process. The complex of pro inflammatory cytokines is, probably, the major factor of demyelination (1,3,7).


Multiple Sclerosis Peripheral Blood Mononuclear Cell Multiple Sclerosis Patient Myelin Basic Protein Cytokine mRNA Expression 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Irina A. Goldina
    • 1
  • Marina N. Tuzova
    • 1
  • Alexander A. Smagin
    • 2
  • Vitaly V. Morozov
    • 2
  • Michel S. Lubarsky
    • 1
  • Konstantin V. Gaidul
    • 1
  • Vladimir A. Kozlov
    • 1
  1. 1.Institute of Clinical ImmunologyNovosibirskRussia
  2. 2.Institute of Clinical and Experimental LymphologyNovosibirskRussia

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